专利检索 ap:("Protein Potential, LLC") AND inv:"KOPECKO, Dennis J." 第 1 页

1.

发明公开
LIVE ATTENUATED ORAL VACCINE AGAINST SHIGELLOSIS AND TYPHOID FEVER 审中-公开
标题翻译：减毒口服疫苗对SHIGELLOSIS和TYPHOID FEVER

公开(公告)号：EP3319629A1

公开(公告)日：2018-05-16

申请号：EP16821934.3

申请日：2016-07-06

申请人： Protein Potential, LLC

发明人： WU, Yun , KOPECKO, Dennis J. , SIM, B. Kim Lee , HOFFMAN, Stephen L.

IPC分类号： A61K39/02 , A61K39/112 , A61P31/04

CPC分类号： A61K39/0283 , A61K39/0275 , A61K2039/522 , A61K2039/523 , A61K2039/543 , A61K2039/70 , Y02A50/476 , Y02A50/484

摘要： Disclosed is the attenuated Salmonella typhi vaccine Ty21a utilized as a vector for Shigella and/or enterotoxogenic E. coli genes stably integrated in the Ty21a chromosome. These genes include a heterologous Shigella sonnei O-antigen biosynthetic gene region that comprises the wzz gene and expresses Shigella sonnei form 1 O-antigen, as well as a heterologous acid resistance biosynthetic gene system comprising a YbaS gene, which enables increased stability of the Ty21a vector at pH 2.5 relative to Ty21a without the integrated acid resistance biosynthetic gene system.