公开(公告)号：EP2155675A1

公开(公告)日：2010-02-24

申请号：EP08768252.2

申请日：2008-06-09

申请人： Provid Pharmaceuticals, Inc. ,  The United States of America as represented by the Department of Health and Human Services

发明人： SHOEMAKER, Robert ,  CARDELLINA, John ,  CURRENS, Michael ,  KONDAPAKA, Sudhir ,  POMMIER, Yves ,  JOBSON, Andy ,  SCUDIERO, Dominic ,  WAUGH, David ,  LOUNTOS, George ,  COOK, Charles, M. ,  ZHANG, Guangtao ,  COLASANTI, Andrew ,  SELF, Christopher, R.

IPC分类号： C07D209/42 ,  C07D209/60 ,  C07D213/86 ,  C07D217/26 ,  C07D231/56 ,  C07D233/52 ,  C07D239/42 ,  C07D277/50 ,  C07D277/82 ,  C07D307/68 ,  C07D307/85 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  A61K31/34

CPC分类号： C07D209/42 ,  C07D209/60 ,  C07D213/86 ,  C07D217/26 ,  C07D231/56 ,  C07D233/52 ,  C07D239/42 ,  C07D277/50 ,  C07D277/82 ,  C07D307/68 ,  C07D307/85 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04

摘要： Provided herein are Compounds having the following structure: formula (I) wherein A, L, X and ring B are as defined herein, compositions comprising an effective amount of a Compound and methods for treating or preventing cancer, hypoxia, diabetes, stroke, autoimmune disease or a condition treatable or preventable by inhibition of Chk2, the ATM-Chk2 pathway or RSK2 comprising administering an effective amount of a Compound to a patient in need thereof.

公开(公告)号：EP2155675B1

公开(公告)日：2014-02-19

申请号：EP08768252.2

申请日：2008-06-09

申请人： Provid Pharmaceuticals, Inc. ,  The United States of America as represented by the Department of Health and Human Services

发明人： SHOEMAKER, Robert ,  CARDELLINA, John ,  CURRENS, Michael ,  KONDAPAKA, Sudhir ,  POMMIER, Yves ,  JOBSON, Andy ,  SCUDIERO, Dominic ,  WAUGH, David ,  LOUNTOS, George ,  COOK, Charles, M. ,  ZHANG, Guangtao ,  COLASANTI, Andrew ,  SELF, Christopher, R.

IPC分类号： C07D209/42 ,  C07D209/60 ,  C07D213/86 ,  C07D217/26 ,  C07D231/56 ,  C07D233/52 ,  C07D239/42 ,  C07D277/50 ,  C07D277/82 ,  C07D307/68 ,  C07D307/85 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  A61K31/34

CPC分类号： C07D209/42 ,  C07D209/60 ,  C07D213/86 ,  C07D217/26 ,  C07D231/56 ,  C07D233/52 ,  C07D239/42 ,  C07D277/50 ,  C07D277/82 ,  C07D307/68 ,  C07D307/85 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04