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公开(公告)号：EP3149172B1
公开(公告)日：2018-07-18
申请号：EP15729289.7
申请日：2015-05-27
发明人： SQUIERS, Elizabeth C. , ERLICH, Shai , ROTHENSTEIN, Daniel , SHARON, Nir , ODENHEIMER, Daniel J. , FEINSTEIN, Elena
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/1135 , A61K9/0019 , A61K31/713 , A61K45/06 , C12N2310/14 , C12N2310/317 , C12N2310/319 , C12N2310/321 , C12N2310/3515 , C12N2320/30 , C12N2310/3521
摘要： The invention, in some embodiments, relates to compounds and methods for the prevention of ischemia reperfusion injury (IRI) in organs, and in particular to IRI in organs aged 35 years and older. Specific uses include prevention of IRI in native organs in vivo, in reimplantations and in transplantations of donor organs aged 35 years and older. Additional embodiments include the prophylaxis of delayed graft function (DGF) and reduction in the frequency, amount and duration of dialysis in recipients of deceased donor kidney transplantations. The methods entail contacting the organ in vivo or ex vivo with a temporary p53 inhibitor. Novel temporary dsNA p53 inhibitors are further provided.
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2.发明授权OLIGORIBONUCLEOTIDES AND METHODS OF USE THEREOF FOR TREATMENT OF ALOPECIA, ACUTE RENAL FAILURE AND OTHER DISEASES 有权寡核糖核苷酸及其使用用于治疗脱发的治疗方法，急性肾功能衰竭等病症
公开(公告)号：EP1799269B1
公开(公告)日：2016-09-07
申请号：EP05788492.6
申请日：2005-09-27
发明人： FEINSTEIN, Elena , ZURR, Daniel , EHRLICH, Shai
IPC分类号： C12N15/113 , A61K31/713 , C07H21/02 , A61P13/12 , A61P17/14 , A61P25/00 , A61P27/16
CPC分类号： C12N15/1135 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2320/30
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3.发明公开METHODS AND COMPOSITIONS FOR TREATING DISEASES, DISORDERS OR INJURY OF THE NERVOUS SYSTEM 审中-公开方法和组合物以及对疾病，病症或神经系统病变的治疗
公开(公告)号：EP2776565A1
公开(公告)日：2014-09-17
申请号：EP12788061.5
申请日：2012-11-08
发明人： FEINSTEIN, Elena
IPC分类号： C12N15/113 , A61K31/713 , C07K16/40 , C07K16/18 , A61P25/00 , A61P27/00
CPC分类号： C12N15/1136 , A61K31/713 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2320/31 , C12Y304/22055
摘要： Disclosed herein are compositions and methods of use thereof for treating diseases, disorders and injuries of the nervous system, com¬ prising a combination of a RTP801 or RTP801L inhibitor, and a Casp2 inhibitor.
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公开(公告)号：EP2350279A2
公开(公告)日：2011-08-03
申请号：EP09748890.2
申请日：2009-10-22
发明人： FEINSTEIN, Elena , ALPERT, Evgenia , METT, Igor , BAR-ILAN, Amir , SPIVAK, Igor , KALINSKI, Hagar , SLAGER, Netanja
IPC分类号： C12N15/113 , A61K31/711
CPC分类号： C12N15/113 , A61K9/0048 , C12N2310/11 , C12N2310/14 , C12N2320/30
摘要： The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at 5 least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.
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公开(公告)号：EP2242854A2
公开(公告)日：2010-10-27
申请号：EP09702682.7
申请日：2009-01-14
发明人： FEINSTEIN, Elena , KALINSKI, Hagar , METT, Igor , ALPERT, EVGENIA
IPC分类号： C12Q1/68
CPC分类号： C12N15/113 , C12N2310/14 , C12N2320/11
摘要： The present invention relates to compounds, pharmaceutical compositions comprising same and methods of use thereof for the inhibition of certain genes, including SOX9, ASPP1, CTSD, CAPNS1, FAS and FAS ligand. The compounds and compositions are useful in the treatment of subjects suffering from diseases or conditions and or symptoms associated with diseases or conditions in which gene expression has adverse consequences.
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公开(公告)号：EP2137205A2
公开(公告)日：2009-12-30
申请号：EP08726066.7
申请日：2008-02-26
发明人： FEINSTEIN, Elena , SKALITER, Rami
CPC分类号： C07H21/02 , C12N15/1136 , C12N2310/11 , C12N2310/14
摘要： The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases respiratory conditions and hearing disorders based upon inhibition of the RTP801 gene and/or protein.
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公开(公告)号：EP2895608B1
公开(公告)日：2018-12-05
申请号：EP13776599.6
申请日：2013-09-12
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/113 , C12N15/1135 , C12N15/1136 , C12N2310/14 , C12N2310/317 , C12N2310/319 , C12N2310/321 , C12N2310/3521 , C12N2320/30
摘要： The present application relates to nucleic acid compounds, compositions comprising same and methods of use thereof for treatment of various diseases, disorders and conditions. The compounds are preferably chemically synthesized and modified double-stranded nucleic acid molecules which down regulate expression of a p53 gene.
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公开(公告)号：EP3276004A3
公开(公告)日：2018-03-14
申请号：EP17190227.3
申请日：2010-06-07
申请人： Quark Pharmaceuticals, Inc. , The United States of America, as Represented by the Department of Veterans Affairs
IPC分类号： C12N15/113 , A61K31/7088
摘要： The present invention relates to oligonucleotide compounds for use in methods for treating chronic kidney disease (CKD) including methods for preventing or delaying onset of CKD and methods for preventing exacerbation and progression of CKD. In particular embodiments, the invention provides methods for treating a subject at risk of developing CKD comprising administering to the subject a composition comprising a) a therapeutically effective amount of at least one oligonucleotide compound which inhibits the expression of a human target gene associated with the kidney disease chosen from p53 and CASP2; and b) a pharmaceutically acceptable excipient or carrier, or mixtures thereof, thereby reducing the risk of CKD in the subject.
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9.发明授权COMPOUNDS COMPOSITIONS AND METHODS OF TREATING CANCER AND FIBROTIC DISEASES 有权相关的组合物以及用于治疗癌症和疾病纤维化方法
公开(公告)号：EP2411413B1
公开(公告)日：2016-05-11
申请号：EP10722812.4
申请日：2010-03-23
发明人： FEINSTEIN, Elena
IPC分类号： C07K16/28 , A61K47/48 , A61K51/10 , G01N33/577 , C12N5/12
CPC分类号： A61K47/6849 , A61K39/39541 , A61K39/39558 , A61K49/0058 , C07K16/2851 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92
摘要： The present invention provides antibodies or antigen-binding fragments thereof that specifically bind the ENDO180 polypeptide and are internalized thereby, to conjugates comprising the molecules, to compositions comprising the antibodies and conjugates and to methods of using the same for delivery of therapeutic agents to cells that express the ENDO180 polypeptide on the surface of the cell for treating cell proliferative diseases or disorders and fibrosis, and for controlling (modulating) tumor progression.
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10.发明授权DOUBLE STRANDED OLIGONUCLEOTIDE COMPOUNDS COMPRISING POSITIONAL MODIFICATIONS 有权WITH位置中的修饰的双链寡核苷酸化合物
公开(公告)号：EP2649181B1
公开(公告)日：2016-04-27
申请号：EP11797288.5
申请日：2011-12-06
IPC分类号： C12N15/11 , C12N15/113 , C07H21/00
CPC分类号： C12N15/1137 , C12N15/111 , C12N2310/14 , C12N2310/31 , C12N2310/314 , C12N2310/317 , C12N2310/319 , C12N2310/321 , C12N2310/323 , C12N2310/332 , C12N2310/335 , C12N2320/51 , C12N2310/3521
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