-
公开(公告)号：EP2350279A2
公开(公告)日：2011-08-03
申请号：EP09748890.2
申请日：2009-10-22
发明人： FEINSTEIN, Elena , ALPERT, Evgenia , METT, Igor , BAR-ILAN, Amir , SPIVAK, Igor , KALINSKI, Hagar , SLAGER, Netanja
IPC分类号： C12N15/113 , A61K31/711
CPC分类号： C12N15/113 , A61K9/0048 , C12N2310/11 , C12N2310/14 , C12N2320/30
摘要： The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at 5 least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.
-
公开(公告)号：EP2242854A2
公开(公告)日：2010-10-27
申请号：EP09702682.7
申请日：2009-01-14
发明人： FEINSTEIN, Elena , KALINSKI, Hagar , METT, Igor , ALPERT, EVGENIA
IPC分类号： C12Q1/68
CPC分类号： C12N15/113 , C12N2310/14 , C12N2320/11
摘要： The present invention relates to compounds, pharmaceutical compositions comprising same and methods of use thereof for the inhibition of certain genes, including SOX9, ASPP1, CTSD, CAPNS1, FAS and FAS ligand. The compounds and compositions are useful in the treatment of subjects suffering from diseases or conditions and or symptoms associated with diseases or conditions in which gene expression has adverse consequences.
-
公开(公告)号：EP2895608B1
公开(公告)日：2018-12-05
申请号：EP13776599.6
申请日：2013-09-12
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/113 , C12N15/1135 , C12N15/1136 , C12N2310/14 , C12N2310/317 , C12N2310/319 , C12N2310/321 , C12N2310/3521 , C12N2320/30
摘要： The present application relates to nucleic acid compounds, compositions comprising same and methods of use thereof for treatment of various diseases, disorders and conditions. The compounds are preferably chemically synthesized and modified double-stranded nucleic acid molecules which down regulate expression of a p53 gene.
-
公开(公告)号：EP2681315A1
公开(公告)日：2014-01-08
申请号：EP12708475.4
申请日：2012-03-01
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/14 , C12N2310/321 , C12N2310/3521
摘要： Disclosed herein are double stranded nucleic acid molecules and pharmaceutical compositions comprising same useful in the treatment of, inter alia, acute and chronic inflammation, neuropathic pain, primary graft dysfunction (PGD) after lung transplantation in a subject in need thereof. The compounds are preferably chemically synthesized and modified dsRNA compounds, which down regulate or inhibit expression of a Toll like receptor genes.
摘要翻译： 本文公开的是双链核酸分子和药物组合物，其包含用于治疗急性和慢性炎症，神经性疼痛，有需要的受试者肺移植后的原发性移植物功能障碍（PGD）的特征。 化合物优选是化学合成和修饰的dsRNA化合物，其下调或抑制Toll样受体基因的表达。
-
公开(公告)号：EP2585594B1
公开(公告)日：2017-05-31
申请号：EP11728750.8
申请日：2011-06-23
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/1135 , C12N15/1137 , C12N2310/14 , C12N2310/141 , C12N2310/321 , C12Q1/6888
-
公开(公告)号：EP2509991A2
公开(公告)日：2012-10-17
申请号：EP10836656.8
申请日：2010-12-08
发明人： JIN, Xiaomei , YU, Lei , TAKAHASHI, Hirokazu , TANAKA, Yasunobu , NIITSU, Yoshiro , FEINSTEIN, Elena , AVKIN-NACHUM, Sharon , KALINSKI, Hagar , METT, Igor , ERLICH, Shai , SQUIERS, Elizabeth, C. , CHEN, Ning
IPC分类号： C07H21/00 , A61K31/7088
CPC分类号： C12N15/113 , A61K31/713 , C12N2310/11 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/33 , C12N2310/531 , C12N2320/30 , C12N2310/3521
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
-
公开(公告)号：EP2076526A2
公开(公告)日：2009-07-08
申请号：EP07827252.3
申请日：2007-10-25
IPC分类号： C07H21/04
CPC分类号： A61K31/70 , C12N15/113 , C12N15/1136 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/343 , C12N2310/3521
摘要： The invention relates to compounds, in particular siRNAs, which inhibit the expression of specific human genes. The invention also relates to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The present invention also provides a method of treating and/or preventing the incidence or severity of various diseases or conditions associated with the genes and/or symptoms associated with such diseases or conditions comprising administering to a subject in need of treatment for such disease or condition and/or symptom the compound or the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the subject. The invention also provides antibodies which inhibit specified human polypeptides and pharmaceutical compositions comprising one or more such antibodies.
-
公开(公告)号：EP2681314B1
公开(公告)日：2017-11-01
申请号：EP12708474.7
申请日：2012-03-01
发明人： GELMAN, Andrew E. , FEINSTEIN, Elena , ADAMSKY, Svetlana , METT, Igor , KALINSKI, Hagar , AVKIN-NACHUM, Sharon
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/113 , A61K31/713 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/344 , C12N2310/3521
摘要： Disclosed herein are therapeutic methods for treating lung diseases, disorders and injury in a mammal, including treatment of acute respiratory distress syndrome (ARDS), acute lung injury, pulmonary fibrosis (idiopathic), bleomycin induced pulmonary fibrosis, mechanical ventilator induced lung injury, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiolitis obliterans after lung transplantation and lung transplantation-induced acute graft dysfunction, including treatment, prevention or prevention of progression of primary graft failure, ischemia-reperfusion injury, reperfusion injury, reperfusion edema, allograft dysfunction, pulmonary reimplantation response, bronchiolitis obliterans after lung transplantation and/or primary graft dysfunction (PGD) after organ transplantation, in particular in lung transplantation, comprising downregulating the TLR2 gene or both the TLR2 gene and TLR4 gene. Provided herein are compositions, methods and kits for treating lung diseases, disorders and injury.
-
9.发明公开
公开(公告)号：EP2895608A1
公开(公告)日：2015-07-22
申请号：EP13776599.6
申请日：2013-09-12
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/113 , C12N15/1135 , C12N15/1136 , C12N2310/14 , C12N2310/317 , C12N2310/319 , C12N2310/321 , C12N2310/3521 , C12N2320/30
摘要： The present application relates to nucleic acid compounds, compositions comprising same and methods of use thereof for treatment of various diseases, disorders and conditions. The compounds are preferably chemically synthesized and modified double-stranded nucleic acid molecules which down regulate expression of a p53 gene.
-
10.发明公开DOUBLE-STRANDED OLIGONUCLEOTIDE COMPOUNDS FOR TREATING HEARING AND BALANCE DISORDERS 审中-公开用于治疗听力和平衡失调的双链寡核苷酸化合物
公开(公告)号：EP2739637A1
公开(公告)日：2014-06-11
申请号：EP12819429.7
申请日：2012-08-03
IPC分类号： C07H21/00 , C12N15/113 , A61K31/7088
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/332 , C12N2310/333 , C12N2310/3341 , C12N2310/335 , C12N2310/336 , C12N2310/337 , C12N2310/3521 , C12N2310/50
摘要： The present application relates to double stranded nucleic acid compounds, compositions comprising same and methods of use thereof for the treatment of hearing loss in a subject in need thereof. The compounds are preferably chemically synthesized and modified dsRNA molecules which inhibit expression of a gene expressed selected from the group consisting of HES1, HES5, HEY1, HEY2, ID1, ID2, ID3, CDKN1B, and NOTCHl.
-
-
-
-
-
-
-
-
-
搜索结果
20 条记录 (耗时 0.029 秒)
