-
公开(公告)号：EP3774809A1
公开(公告)日：2021-02-17
申请号：EP19720424.1
申请日：2019-04-11
发明人： NAM, Kiyean , KIM, Jaeseung , JEON, Yeejin , YU, Donghoon , SEO, Mooyoung , PARK, Dongsik , EICKHOFF, Jan , ZISCHINSKY, Gunther , KOCH, Uwe
-
2.发明公开
公开(公告)号：EP3774810A1
公开(公告)日：2021-02-17
申请号：EP19720425.8
申请日：2019-04-11
发明人： NAM, Kiyean , KIM, Jaeseung , JEON, Yeejin , YU, Donghoon , SEO, Mooyoung , PARK, Dongsik , EICKHOFF, Jan , ZISCHINSKY, Gunther
IPC分类号： C07D487/04 , C07D519/00 , A61P31/00 , A61P29/00 , A61P35/00 , A61P37/00
-
公开(公告)号：EP2680852A1
公开(公告)日：2014-01-08
申请号：EP12706839.3
申请日：2012-03-01
IPC分类号： A61K31/53 , A61K31/5355 , C07D251/48 , C07D403/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , A61P31/14 , A61P31/16 , A61P31/22 , A61P33/02 , A61P33/10 , A61P33/12 , A61P31/04
CPC分类号： A61K31/5377 , A61K31/53 , A61K31/5355 , A61K45/06 , C07D251/48 , C07D401/04 , C07D403/04 , C07D403/14 , C07D413/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , A61K2300/00
摘要： The present invention relates to disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted triazine derivatives as inhibitors for a protein kinase.
-
公开(公告)号：EP2747755A1
公开(公告)日：2014-07-02
申请号：EP12761554.0
申请日：2012-08-22
发明人： CHOIDAS, Axel , KLEBL, Bert , HABENBERGER, Peter , EICKHOFF, Jan , THOMAS, Roman , HEUCKMANN, Johannes
IPC分类号： A61K31/00 , A61K31/4418 , A61K31/53 , A61P35/00
CPC分类号： C07C53/18 , A61K31/4418 , A61K31/53 , C07D213/40 , C07D213/74 , C07D251/16 , C07D251/22 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/10 , C07D471/04
摘要： The present invention relates to a CDK9 inhibitor, especially a selective CDK9 inhibitor, for use in treating, ameliorating and/or preventing midline carcinoma. Also corresponding methods for treating, preventing or ameliorating midline carcinoma are subject of the present invention. Preferably, NUT midline carcinoma is treated with the CDK9 inhibitors in accordance with the present invention.
-
公开(公告)号：EP2550257B1
公开(公告)日：2016-12-21
申请号：EP11711039.5
申请日：2011-03-20
发明人： EICKHOFF, Jan , NUSSBAUMER, Peter , RÜHTER, Gerd , SCHULTZ-FADEMRECHT, Carsten , LÜCKING, Ulrich , CHOIDAS, Axel , KLEBL, Bert
IPC分类号： C07D251/22 , C07D401/04 , C07D403/12 , C07D407/04 , A61K31/53 , A61P35/00 , A61P37/00 , C07D401/12
CPC分类号： C07D251/16 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D251/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/10 , C07D407/04 , C07D413/10
-
公开(公告)号：EP2609091B1
公开(公告)日：2014-11-26
申请号：EP11754617.6
申请日：2011-08-26
发明人： SCHULTZ-FADEMRECHT, Carsten , KLEBL, Bert , CHOIDAS, Axel , KOCH, Uwe , EICKHOFF, Jan , WOLF, Alexander , ULLRICH, Axel
IPC分类号： C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D215/233 , A61K31/4709 , A61P35/00
CPC分类号： C07D401/12 , A61K31/47 , A61K31/495 , C07D215/233 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
-
公开(公告)号：EP2609091A1
公开(公告)日：2013-07-03
申请号：EP11754617.6
申请日：2011-08-26
发明人： SCHULTZ-FADEMRECHT, Carsten , KLEBL, Bert , CHOIDAS, Axel , KOCH, Uwe , EICKHOFF, Jan , WOLF, Alexander , ULLRICH, Axel
IPC分类号： C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/4709 , A61P35/00
CPC分类号： C07D401/12 , A61K31/47 , A61K31/495 , C07D215/233 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to 1-nitrogen-heterocyclic-2-carboxamides of general formula (I): and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the treatment and/or prevention of Axl receptor tyrosine kinase subfamily induced disorders, including cancer and primary tumor metastases, and pharmaceutical compositions containing at least one of said 1-nitrogen-heterocyclic-2-carboxamide derivatives and/or pharmaceutically acceptable salts thereof.
-
8.发明授权
公开(公告)号：EP3003315B1
公开(公告)日：2018-01-17
申请号：EP14722116.2
申请日：2014-05-07
IPC分类号： A61K31/506 , A61K31/4709 , A61K45/06 , A61P35/00 , A61P31/00 , A61P29/00 , A61P27/06 , A61P25/28 , A61P19/02 , A61P17/06 , A61P15/00 , A61P9/10 , C07D401/14
CPC分类号： C07D401/14 , A61K31/4709 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： The compound N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-5-ethyl-1-(pyrimidin-5-yl)-1H-pyrazole-4-carboxamide and pharmaceutically usable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios, is an inhibitor of RON and can be employed, for the treatment of cancer.
-
公开(公告)号：EP2748331B1
公开(公告)日：2016-03-02
申请号：EP12761556.5
申请日：2012-08-22
发明人： CHOIDAS, Axel , KLEBL, Bert , HABENBERGER, Peter , EICKHOFF, Jan , THOMAS, Roman , HEUCKMANN, Johannes
IPC分类号： C12Q1/68
CPC分类号： G01N33/5011 , C12Q1/6881 , C12Q1/6886 , C12Q2600/106 , G01N2800/52
-
公开(公告)号：EP2681193B1
公开(公告)日：2016-01-06
申请号：EP12706263.6
申请日：2012-03-01
发明人： RÜHTER, Gerd , NUSSBAUMER, Peter , CHOIDAS, Axel , SCHULTZ-FADEMRECHT, Carsten , KLEBL, Bert , EICKHOFF, Jan
IPC分类号： C07D213/74 , A61K31/44 , A61P35/00
CPC分类号： C07D213/74 , A61K31/4418 , A61K45/06
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.023 秒)
