公开(公告)号：EP1658283A2

公开(公告)日：2006-05-24

申请号：EP04735296.8

申请日：2004-05-28

申请人： RANBAXY LABORATORIES, LTD.

发明人： SALMAN, Mohammad ,  SATTIGERI, Jitendra ,  KUMAR, Yatendra ,  ARYAN, Ram Chander ,  RAMANATHAN, Vikram Krishna ,  CHUGH, Anita

IPC分类号： C07D405/06

CPC分类号： C07D207/34 ,  A61K31/40 ,  C07C69/716 ,  C07C69/738 ,  C07D401/12 ,  C07D403/04 ,  C07D405/06 ,  C07D405/14 ,  C07D413/04

摘要： The present invention relates to substituted pyrrole derivatives of formula I, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms. Its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, prodrugs, metabolites, polymorphs, tautomers, racemates, pure enantiomers, diastereoisomers or N-oxides wherein Formula (II).

公开(公告)号：EP1626954A2

公开(公告)日：2006-02-22

申请号：EP04731224.4

申请日：2004-05-05

申请人： RANBAXY LABORATORIES, LTD.

发明人： KAROOTI, Kiran Kumar Ganagakhedkar Shubham ,  RATHOD, Parendu Dhirajlal ,  ARYAN, Ram Chander ,  KUMAR, Yatendra

IPC分类号： C07D205/08

CPC分类号： C07D309/30 ,  C07C51/09 ,  C07D205/08 ,  C07C59/56

摘要： The invention relates to processes for the preparation of trans-isomers of diphenylazetidinone derivatives of formula (I), using a chiral delta-lactone. It also relates to processes for the preparation of the chiral delta-lactone. The invention also relates to pharmaceutical compositions that include the trans-isomers of diphenylazetidinone derivatives.

公开(公告)号：EP1395588A2

公开(公告)日：2004-03-10

申请号：EP02730574.7

申请日：2002-05-20

申请人： RANBAXY LABORATORIES, LTD.

发明人： KUMAR, Yatendra ,  TEWARI, Neera ,  ARYAN, Ram Chander ,  RAI, Bishwa Prakash

IPC分类号： C07D477/20

CPC分类号： C07D477/20 ,  C07D477/02

摘要： The present invention relates to a cost effective and industrially advantageous process for the preparation of imipenem of high purity.