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公开(公告)号：EP1968980A1
公开(公告)日：2008-09-17
申请号：EP07700030.5
申请日：2007-01-02
发明人： KUMAR, Naresh , CLIFFE, Ian, Anthony , SALMAN, Mohammad , PALLE, Venkata, P. , KAUR, Kirandeep , SHEJUL, Yogesh, D. , CHUGH, Anita , GUPTA, Suman , RAY, Abhijit , MALHOTRA, Shivani , SHIRUMALLA, Raj, Kumar
IPC分类号： C07D487/08 , A61K31/403
CPC分类号： C07D209/52
摘要： This present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.
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公开(公告)号：EP1597231A1
公开(公告)日：2005-11-23
申请号：EP03702904.8
申请日：2003-02-20
发明人： ARORA, Jasbir, Singh , GUPTA, Nidhi , SALMAN, Mohammad , GUPTA, Jang, Bahadur , PANDIT, Upendra, Kumar
IPC分类号： C07D211/76 , C07D211/46 , C07D409/12 , C07D401/06 , C07D401/12 , A61K31/4545 , A61P35/04
CPC分类号： C07D401/06 , C07D211/46 , C07D211/76 , C07D401/12 , C07D409/12
摘要： Certain derivatives of azasugars, useful in the treatment of cancer, are presented. This invention also relates to pharmacological compositions containing the compounds of present invention and treatment of cancer, including tumor or other neoplasm, with an azasugar.
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3.发明公开A COST EFFECTIVE METHOD FOR SELECTIVE METHYLATION OF ERYTHROMYCIN A DERIVATIVES 有权成本效益的方法红霉素A衍生物选择性甲基
公开(公告)号：EP1283821A2
公开(公告)日：2003-02-19
申请号：EP01936695.4
申请日：2001-05-07
发明人： SALMAN, Mohammad , RAY, Purna, Chandra , GANGAKHEDKAR, Kiran Kumar , LAL DORWAL, Harish Niranjan , KUMAR, Naresh
IPC分类号： C07C1/00
CPC分类号： C07H17/08
摘要： The present invention relates to a cost effective and industrially advantageous process for the selective methylation of a hydroxy group at the 6 position of erythromycin A derivatives.
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公开(公告)号：EP1663999A2
公开(公告)日：2006-06-07
申请号：EP04769218.1
申请日：2004-08-30
发明人： PALLE, Venkata P., D-011, Oakwood Estate , BALACHANDRAN, Sarala, A-6, Nat. Inst. Immunology , SALMAN, Mohammad , KUKREJA, Gagan, LD-166, Sardar Patel Apart. , GUPTA, Nidhi , RAY, Abhijit , DASTIDAR, Sunanda, G.
IPC分类号： C07D261/04
CPC分类号： C07D261/04 , C07D498/10
摘要： The present invention relates to isoxazoline derivatives of structure (I), which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors. Formula I.
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公开(公告)号：EP1551803A1
公开(公告)日：2005-07-13
申请号：EP03762827.8
申请日：2003-04-11
发明人： SALMAN, Mohammad , MEHTA, Anita , SARMA, Pakala, Kumara, Savithru , SHETTY, Shankar, Jayram , DHARMARAJAN, Sankaranarayanan , KUMAR, Naresh , SILAMKOTI, Arundutt, Viswanatham , CHUGH, Anita
IPC分类号： C07D209/52 , C07D403/12 , C07D417/12 , C07D413/12 , C07D401/12 , C07D407/12 , A61K31/403
CPC分类号： C07D401/12 , C07D209/52 , C07D403/12 , C07D413/12 , C07D417/12
摘要： This invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0] hexanes, and 2,4,6-trisubstituted derivatives. The invention also relates to pharmaceutical compositions containing the compounds and the methods of treating the diseases mediated through muscarinic receptors.
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6.发明公开ALPHA, OMEGA-DICARBOXIMIDE DERIVATIVES AS USEFUL URO-SELECTIVE A1A ADRENOCEPTOR BLOCKERS 审中-公开ALPHA，OMEGA-DICARBOXIMIDE DERIVATIVES作为有效的尿液选择性A1A ADRENOCEPTOR BLOCKERS
公开(公告)号：EP1495000A1
公开(公告)日：2005-01-12
申请号：EP02722544.0
申请日：2002-04-08
发明人： SALMAN, Mohammad , YADAV, Gyan, Chand , SHARMA, Somesh , KAPKOTI, Gobind, Singh , CHUGH, Anita , GUPTA, Jang, Bahadur , ANAND, Nitya
IPC分类号： C07D209/48 , C07D401/06 , C07D403/06 , C07D491/08 , A61K31/4035 , A61K31/496
CPC分类号： C07D209/48 , C07D403/06 , C07D491/04
摘要： Novel α,ω-dicarboximide derivatives which selectively inhibit binding to the α-1A adrenergic receptor, a receptor which has been shown to be important in the treatment of benign prostatic hyperplasia. The compounds of the present invention are potentially useful in the treatment of benign prostatic hyperplasia.
摘要翻译： 新的α，ω-二甲酰亚胺衍生物，其选择性地抑制与α-1A肾上腺素能受体的结合，α-1A肾上腺素能受体已被证明在治疗良性前列腺增生中是重要的。 本发明的化合物可能用于治疗良性前列腺增生。
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公开(公告)号：EP1432682A1
公开(公告)日：2004-06-30
申请号：EP02775017.3
申请日：2002-09-24
IPC分类号： C07D211/32 , A61K31/445 , A61P3/10
CPC分类号： C07D295/135
摘要： The present invention relates to a cost effective and industrially advantageous process for the preparation of repaglinide.
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公开(公告)号：EP1204637A1
公开(公告)日：2002-05-15
申请号：EP00944156.9
申请日：2000-07-24
IPC分类号： C07C403/20
CPC分类号： C07C403/20 , C07C51/353 , C07C2601/16 , C07D309/32 , C07C57/26
摘要： The present invention relates to a process for the preparation of 13-cis isomer of Vitamin A acid, commonly known as isotretinoin, in a single step.
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9.发明公开3 -AZABICYCLOOCTANE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开3 -AZABICYCLOOCTANDERIVATE作为拮抗剂毒蕈碱受体
公开(公告)号：EP1934184A1
公开(公告)日：2008-06-25
申请号：EP06809514.0
申请日：2006-10-05
发明人： KUMAR, Naresh , KAUR, Kirandeep , GUPTA, Suman , CHUGH, Anita , SALMAN, Mohammad , SHIRUMALLA, Raj, Kumar , MALHOTRA, Shivani
IPC分类号： C07D221/24 , C07D409/12 , C07D405/12 , A61K31/439 , A61P11/00 , A61P13/00
CPC分类号： C07D221/24 , C07D405/12 , C07D409/12
摘要： Provided are muscarinic receptor antagonists, which can be useful in treating various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Also provided are processes for preparing compounds described herein, pharmaceutical compositions thereof, and methods for treating diseases mediated through muscarinic receptors.
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10.发明公开SYNTHESIS OF 3-ETHOXY-4-ETHOXYCARBONYL PHENYL ACETIC ACID, A KEY ACID SYNTHON OF REPAGLINIDE 审中-公开合成3-乙氧基-4-乙氧基羰基苯乙酸，一种关键酸式合成铼
公开(公告)号：EP1751084A2
公开(公告)日：2007-02-14
申请号：EP00954859.5
申请日：2000-09-11
IPC分类号： C07C69/76
CPC分类号： C07C67/10 , C07C67/313 , C07C69/92
摘要： The present invention relates to a new and industrially advantageous process for the preparation of 3-ethoxy-4-ethoxycarbonyl-phenyl acetic acid. This compound is a key intermediate for the synthesis of Repaglinide, an oral hypoglycemic agent.
摘要翻译： 本发明涉及制备3-乙氧基-4-乙氧基羰基苯基乙酸的新的工业上有利的方法。 该化合物是合成瑞格列奈（口服降血糖药）的关键中间体。
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