公开(公告)号：EP1551803A1

公开(公告)日：2005-07-13

申请号：EP03762827.8

申请日：2003-04-11

申请人： RANBAXY LABORATORIES, LTD.

发明人： SALMAN, Mohammad ,  MEHTA, Anita ,  SARMA, Pakala, Kumara, Savithru ,  SHETTY, Shankar, Jayram ,  DHARMARAJAN, Sankaranarayanan ,  KUMAR, Naresh ,  SILAMKOTI, Arundutt, Viswanatham ,  CHUGH, Anita

IPC分类号： C07D209/52 ,  C07D403/12 ,  C07D417/12 ,  C07D413/12 ,  C07D401/12 ,  C07D407/12 ,  A61K31/403

CPC分类号： C07D401/12 ,  C07D209/52 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

摘要： This invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0] hexanes, and 2,4,6-trisubstituted derivatives. The invention also relates to pharmaceutical compositions containing the compounds and the methods of treating the diseases mediated through muscarinic receptors.

公开(公告)号：EP1551803B1

公开(公告)日：2006-10-11

申请号：EP03762827.8

申请日：2003-04-11

申请人： RANBAXY LABORATORIES, LTD.

发明人： SALMAN, Mohammad ,  MEHTA, Anita ,  SARMA, Pakala, Kumara, Savithru ,  SHETTY, Shankar, Jayram ,  DHARMARAJAN, Sankaranarayanan ,  KUMAR, Naresh ,  SILAMKOTI, Arundutt, Viswanatham ,  CHUGH, Anita

IPC分类号： C07D209/52 ,  C07D403/12 ,  C07D417/12 ,  C07D413/12 ,  C07D401/12 ,  C07D407/12 ,  A61K31/403

CPC分类号： C07D401/12 ,  C07D209/52 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

摘要： This invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0] hexanes, and 2,4,6-trisubstituted derivatives. The invention also relates to pharmaceutical compositions containing the compounds and the methods of treating the diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及毒蕈碱受体拮抗剂，其除其他用途外可用于治疗通过毒蕈碱受体介导的呼吸系统，泌尿系统和胃肠系统的各种疾病。 具体而言，本发明涉及氮杂双环化合物的衍生物，包括例如6-取代氮杂双环[3.1.0]己烷和2,4,6-三取代衍生物。 本发明还涉及含有该化合物的药物组合物和治疗通过毒蕈碱受体介导的疾病的方法。