公开(公告)号：EP0069600A3

公开(公告)日：1984-04-04

申请号：EP82303582

申请日：1982-07-08

申请人： RECKITT AND COLMAN PRODUCTS LIMITED

发明人： Todd, Richard Sydney

IPC分类号： A61K31/485 ,  A61K09/08

CPC分类号： A61K9/006 ,  A61K31/485

摘要： A pharmaceutical composition for sublingual administration comprising buprenorphine or a non-toxic salt thereof dissolved in 20-30% v/v aqueous ethanol buffered to between pH 4.5 to 5.5 with 0.05 to 0.2 molar concentration of a buffering agent selected from citric acid/disodium hydrogen phosphate, sodium citrate/hydrochloric acid, lactic acid/ disodium hydrogen phosphate, lactic acid/sodium lactate, sodium citrate/citric acid and sodium acetate/acetic acid, the concentration of buprenorphine being between 0.8 and 10 mg/ml of the composition. Buprenorphine is a potent antagonist analgesic with good bioavailability following sublingual administration, useful in the relief of moderate to severe pain and also in the treatment of natcotic addiction. The compositions enable higher doses of buprenorphine to be administered sublingually.

摘要翻译： 一种用于舌下给药的药物组合物，其包含丁丙诺啡或其无毒盐溶解在缓冲至pH 4.5至5.5之间的20-30％v / v含水乙醇中，0.05至0.2摩尔浓度的选自柠檬酸/氢氧化钠的缓冲剂 磷酸盐，柠檬酸钠/盐酸，乳酸/磷酸氢二钠，乳酸/乳酸钠，柠檬酸钠/柠檬酸和乙酸钠/乙酸，组合物中丁丙诺啡浓度在0.8〜10mg / ml之间。 丁丙诺啡是舌下施用后具有良好生物利用度的强效拮抗剂止痛剂，可用于缓解中度至重度疼痛，也可用于治疗自发性成瘾。 该组合物使得能够在舌下施用较高剂量的丁丙诺啡。

公开(公告)号：EP0069600A2

公开(公告)日：1983-01-12

申请号：EP82303582.9

申请日：1982-07-08

申请人： RECKITT AND COLMAN PRODUCTS LIMITED

发明人： Todd, Richard Sydney

IPC分类号： A61K31/485 ,  A61K9/08

CPC分类号： A61K9/006 ,  A61K31/485

摘要： A pharmaceutical composition for sublingual administration comprising buprenorphine or a non-toxic salt thereof dissolved in 20-30% v/v aqueous ethanol buffered to between pH 4.5 to 5.5 with 0.05 to 0.2 molar concentration of a buffering agent selected from citric acid/disodium hydrogen phosphate, sodium citrate/hydrochloric acid, lactic acid/ disodium hydrogen phosphate, lactic acid/sodium lactate, sodium citrate/citric acid and sodium acetate/acetic acid, the concentration of buprenorphine being between 0.8 and 10 mg/ml of the composition. Buprenorphine is a potent antagonist analgesic with good bioavailability following sublingual administration, useful in the relief of moderate to severe pain and also in the treatment of natcotic addiction. The compositions enable higher doses of buprenorphine to be administered sublingually.

摘要翻译： 一种用于舌下给药的药物组合物，其包含丁丙诺啡或其无毒盐溶于20-30％v / v乙醇水溶液中并缓冲至pH 4.5至5.5，其中0.05至0.2摩尔浓度的缓冲剂选自柠檬酸/氢化二钠 磷酸盐，柠檬酸钠/盐酸，乳酸/磷酸氢二钠，乳酸/乳酸钠，柠檬酸钠/柠檬酸和乙酸钠/乙酸，丁丙诺啡的浓度为0.8-10mg / ml。 丁丙诺啡是一种有效的拮抗剂镇痛药，在舌下给药后具有良好的生物利用度，可用于缓解中度至重度疼痛以及治疗霉菌成瘾。 该组合物使舌下施用更高剂量的丁丙诺啡。