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1.发明授权THERAPEUTIC USE OF A Dll4 ANTAGONIST AND A VEGF INHIBITOR FOR INHIBITING TUMOR GROWTH 有权Dll4的拮抗剂的治疗用途和VEGF抑制剂用于抑制肿瘤生长
公开(公告)号：EP1962895B2
公开(公告)日：2016-01-20
申请号：EP06848586.1
申请日：2006-12-15
发明人： NOGUERA, Irene , THURSTON, Gavin , GALE, Nicholas , SMITH, Eric
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A01K2267/0331 , C07K2319/30 , C12N2799/022 , C12N2799/027
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2.发明授权THERAPEUTIC USE OF A Dll4 ANTAGONIST AND A VEGF INHIBITOR FOR INHIBITING TUMOR GROWTH 有权Dll4的拮抗剂的治疗用途和VEGF抑制剂用于抑制肿瘤生长
公开(公告)号：EP1962895B1
公开(公告)日：2013-02-13
申请号：EP06848586.1
申请日：2006-12-15
发明人： NOGUERA, Irene , THURSTON, Gavin , GALE, Nicholas , SMITH, Eric
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A01K2267/0331 , C07K2319/30 , C12N2799/022 , C12N2799/027
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3.发明公开THERAPEUTIC METHODS FOR INHIBITING TUMOR GROWTH WITH DLL4 ANTAGONISTS 有权Dll4的拮抗剂的治疗用途和VEGF抑制剂用于抑制肿瘤生长
公开(公告)号：EP1962895A2
公开(公告)日：2008-09-03
申请号：EP06848586.1
申请日：2006-12-15
发明人： NOGUERA, Irene , THURSTON, Gavin , GALE, Nicholas , SMITH, Eric
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A01K2267/0331 , C07K2319/30 , C12N2799/022 , C12N2799/027
摘要： A therapeutic method for inhibiting tumor development or growth, comprising administering an agent capable of inhibiting human delta-like ligand 4 (DII4) activity to a subject in need thereof. In one embodiment, the agent is an anti-DII4 antibody or antibody fragment capable of inhibiting the binding of DII4 to a Notch receptor. In another embodiment, the agent is a fusion protein comprising the extracellular domain of DII4 or a fragment or variant thereof, fused to a multimerizing component such as an Fc domain. The method of the invention is useful for inhibiting tumor growth, particularly in tumors which are not responsive to other therapeutic agents.
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