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1.发明授权THERAPEUTIC USE OF A Dll4 ANTAGONIST AND A VEGF INHIBITOR FOR INHIBITING TUMOR GROWTH 有权Dll4的拮抗剂的治疗用途和VEGF抑制剂用于抑制肿瘤生长
公开(公告)号：EP1962895B2
公开(公告)日：2016-01-20
申请号：EP06848586.1
申请日：2006-12-15
发明人： NOGUERA, Irene , THURSTON, Gavin , GALE, Nicholas , SMITH, Eric
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A01K2267/0331 , C07K2319/30 , C12N2799/022 , C12N2799/027
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公开(公告)号：EP0758381B1
公开(公告)日：2003-02-19
申请号：EP95916204.1
申请日：1995-04-04
发明人： DAVIS, Samuel , GALE, Nicholas , ALDRICH, Thomas H. , MAISONPIERRE, Peter C. , GOLDFARB, Mitchell , YANCOPOULOS, George D.
CPC分类号： C07K14/4702
摘要： Novel ligands that bind Eph family receptors are identified, and methods for making the soluble ligands in biologically active form are described. cDNA clones encoding these novel proteins enable production of the recombinant proteins, which are useful to support neuronal and other receptor-bearing cell populations.
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公开(公告)号：EP0758381A1
公开(公告)日：1997-02-19
申请号：EP95916204.0
申请日：1995-04-04
发明人： DAVIS, Samuel , GALE, Nicholas , ALDRICH, Thomas H. , MAISONPIERRE, Peter C. , GOLDFARB, Mitchell , YANCOPOULOS, George D.
CPC分类号： C07K14/4702
摘要： Novel ligands that bind Eph family receptors are identified, and methods for making the soluble ligands in biologically active form are described. cDNA clones encoding these novel proteins enable production of the recombinant proteins, which are useful to support neuronal and other receptor-bearing cell populations.
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4.发明公开
公开(公告)号：EP2943280A1
公开(公告)日：2015-11-18
申请号：EP14701266.0
申请日：2014-01-09
IPC分类号： B01L3/00
CPC分类号： C12M23/12 , B01L3/5085 , B01L2200/026 , B01L2300/0609 , B01L2300/0618 , B01L2300/0681 , B01L2300/0829 , B01L2300/0851 , B01L2300/0858 , C12M29/00 , G01N35/0099
摘要： A system for processing samples by a robotic platform has a tray that defines a well defining a drain. The well has a bottom surface, an access port in fluid communication with the drain, and an insert adapted to be received in the well. The insert has a bottom wall and a side wall. At least one of the bottom wall and the side wall define a plurality of openings, such that an interior of the insert is in fluid communication with the well when the insert is inserted into the well.
摘要翻译： 用于通过机器人平台处理样品的系统具有限定排出物的阱的托盘。 井具有底面，与排水口流体连通的进入口和适于容纳在井中的插入件。 插入件具有底壁和侧壁。 底壁和侧壁中的至少一个限定多个开口，使得当插入件插入到井中时，插入件的内部与井流体连通。
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5.发明授权THERAPEUTIC USE OF A Dll4 ANTAGONIST AND A VEGF INHIBITOR FOR INHIBITING TUMOR GROWTH 有权Dll4的拮抗剂的治疗用途和VEGF抑制剂用于抑制肿瘤生长
公开(公告)号：EP1962895B1
公开(公告)日：2013-02-13
申请号：EP06848586.1
申请日：2006-12-15
发明人： NOGUERA, Irene , THURSTON, Gavin , GALE, Nicholas , SMITH, Eric
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A01K2267/0331 , C07K2319/30 , C12N2799/022 , C12N2799/027
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6.发明公开THERAPEUTIC METHODS FOR INHIBITING TUMOR GROWTH WITH DLL4 ANTAGONISTS 有权Dll4的拮抗剂的治疗用途和VEGF抑制剂用于抑制肿瘤生长
公开(公告)号：EP1962895A2
公开(公告)日：2008-09-03
申请号：EP06848586.1
申请日：2006-12-15
发明人： NOGUERA, Irene , THURSTON, Gavin , GALE, Nicholas , SMITH, Eric
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A01K2267/0331 , C07K2319/30 , C12N2799/022 , C12N2799/027
摘要： A therapeutic method for inhibiting tumor development or growth, comprising administering an agent capable of inhibiting human delta-like ligand 4 (DII4) activity to a subject in need thereof. In one embodiment, the agent is an anti-DII4 antibody or antibody fragment capable of inhibiting the binding of DII4 to a Notch receptor. In another embodiment, the agent is a fusion protein comprising the extracellular domain of DII4 or a fragment or variant thereof, fused to a multimerizing component such as an Fc domain. The method of the invention is useful for inhibiting tumor growth, particularly in tumors which are not responsive to other therapeutic agents.
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公开(公告)号：EP0758381B2
公开(公告)日：2006-11-15
申请号：EP95916204.1
申请日：1995-04-04
发明人： DAVIS, Samuel , GALE, Nicholas , ALDRICH, Thomas H. , MAISONPIERRE, Peter C. , GOLDFARB, Mitchell , YANCOPOULOS, George D.
IPC分类号： C07K14/47
CPC分类号： C07K14/4702
摘要： Novel ligands that bind Eph family receptors are identified, and methods for making the soluble ligands in biologically active form are described. cDNA clones encoding these novel proteins enable production of the recombinant proteins, which are useful to support neuronal and other receptor-bearing cell populations.
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