公开(公告)号：EP2054504A2

公开(公告)日：2009-05-06

申请号：EP07804055.7

申请日：2007-08-28

申请人： REINNERVATE LIMITED

发明人： PRZYBORSKI, Stefan ,  WHITING, Andrew ,  MARDER, Todd

IPC分类号： C12N5/00 ,  C07C63/66 ,  C07C57/50 ,  C07C259/10 ,  A61K31/235 ,  A61K31/216

CPC分类号： C12N5/0606 ,  A61K31/216 ,  A61K31/235 ,  C07C57/50 ,  C07C63/66 ,  C12N2501/385

摘要： The invention relates to retinoid compounds of one of the following formulae: Formula 6 a; R = H D1 R = Me (i) PaIa-CO2R' QC = H or Me) (ii)Imeta-CO2R' (R' = H or Me) (iii) ortho-CO2R' (R1 = H or Me) Formula 10 a,R = H b; R = Me (i) PaIa-CO2R' QC = H or Me) (ii)Imeta-CO2R' (R' = H or Me) (iii) ortho-CO2R' (R1 = H or Me) Formula 11 a; R = H b; R =Me (i) para-CONHOH (u)meta-CONHOH (ui)orttho-CONH0H Formula 12 (i) PaIa-CO2H (R = H or Me. R' = H or Me) (ii) meta-CO2H (R = H or Me, R' = H orM) Formula 13 R = H or Me, R' = H or M or a salt thereof, and to the use of such compounds in the control of cell differentiation.