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1.发明公开MEMBRANE VIRUS HOST RANGE MUTATIONS AND THEIR USES AS VACCINE SUBSTRATES 有权FOR A WITSSPEKTRUM病毒膜突变及其作为VAKZINSUBSTRAT
公开(公告)号：EP1037603A1
公开(公告)日：2000-09-27
申请号：EP98947150.3
申请日：1998-09-18
IPC分类号： A61K9/00
CPC分类号： C07K14/005 , C12N7/00 , C12N2770/36122 , C12N2770/36161
摘要： The vaccines and methods of the present invention are based on deletion mutations in the protein transmembrane domains of membrane-enveloped viruses. The strategy for production of these mutations is based on the fact that unlike mammalian cell membranes, the membranes of insect cells contain no cholesterol; thus are thinner than mammalian membranes. Many membrane-coated viruses have membrane glycoproteins on their surface which are responsible for identifying and infecting target cells. These membrane glycoproteins have hydrophobic membrane-spanning domains which anchor the proteins in the membrane bilayer. The membrane-spanning domains of these transmembrane proteins must be long enough to reach from one side of the bilayer to the other in order to hold the proteins in the membrane. Provided is a vaccine, a method of producing this vaccine, and a method of using this vaccine, based on the differences between membranes of viruses replicated in invertebrates and membranes of viruses replicated in vertebrates.
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2.发明授权MEMBRANE VIRUS HOST RANGE MUTATIONS AND THEIR USES AS VACCINE SUBSTRATES 有权FOR A WITSSPEKTRUM病毒膜突变及其作为VAKZINSUBSTRAT
公开(公告)号：EP1037603B1
公开(公告)日：2006-11-22
申请号：EP98947150.3
申请日：1998-09-18
CPC分类号： C07K14/005 , C12N7/00 , C12N2770/36122 , C12N2770/36161
摘要： The vaccines and methods of the present invention are based on deletion mutations in the protein transmembrane domains of membrane-enveloped viruses. The strategy for production of these mutations is based on the fact that unlike mammalian cell membranes, the membranes of insect cells contain no cholesterol; thus are thinner than mammalian membranes. Many membrane-coated viruses have membrane glycoproteins on their surface which are responsible for identifying and infecting target cells. These membrane glycoproteins have hydrophobic membrane-spanning domains which anchor the proteins in the membrane bilayer. The membrane-spanning domains of these transmembrane proteins must be long enough to reach from one side of the bilayer to the other in order to hold the proteins in the membrane. Provided is a vaccine, a method of producing this vaccine, and a method of using this vaccine, based on the differences between membranes of viruses replicated in invertebrates and membranes of viruses replicated in vertebrates.
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3.发明公开MEMBRANE VIRUS HOST RANGE MUTATIONS AND THEIR USES AS VACCINE SUBSTRATES 审中-公开REED突变担心病毒的宿主谱和用途疫苗SUBSTRATES
公开(公告)号：EP1234023A1
公开(公告)日：2002-08-28
申请号：EP00925871.6
申请日：2000-03-14
IPC分类号： C12N7/04
CPC分类号： C12N7/00 , A61K2039/5254 , C07K14/005 , C12N2760/18822 , C12N2760/18823 , C12N2770/36122 , C12N2770/36161
摘要： The present invention is directed to genetically engineered, membrane-enveloped viruses with deletion mutations in the protein transmembrane domains. Also provided are viral vaccines based on the engineered viruses, methods of producing and using such vaccines.
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