利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.016 秒)

    MEMBRANE VIRUS HOST RANGE MUTATIONS AND THEIR USES AS VACCINE SUBSTRATES
    1.
    发明公开
    MEMBRANE VIRUS HOST RANGE MUTATIONS AND THEIR USES AS VACCINE SUBSTRATES 有权
    FOR A WITSSPEKTRUM病毒膜突变及其作为VAKZINSUBSTRAT

    公开(公告)号：EP1037603A1

    公开(公告)日：2000-09-27

    申请号：EP98947150.3

    申请日：1998-09-18

    申请人： RESEARCH DEVELOPMENT FOUNDATION

    发明人： BROWN, Dennis, T. ,  HERNANDEZ, Racquel

    IPC分类号： A61K9/00

    CPC分类号： C07K14/005 ,  C12N7/00 ,  C12N2770/36122 ,  C12N2770/36161

    摘要： The vaccines and methods of the present invention are based on deletion mutations in the protein transmembrane domains of membrane-enveloped viruses. The strategy for production of these mutations is based on the fact that unlike mammalian cell membranes, the membranes of insect cells contain no cholesterol; thus are thinner than mammalian membranes. Many membrane-coated viruses have membrane glycoproteins on their surface which are responsible for identifying and infecting target cells. These membrane glycoproteins have hydrophobic membrane-spanning domains which anchor the proteins in the membrane bilayer. The membrane-spanning domains of these transmembrane proteins must be long enough to reach from one side of the bilayer to the other in order to hold the proteins in the membrane. Provided is a vaccine, a method of producing this vaccine, and a method of using this vaccine, based on the differences between membranes of viruses replicated in invertebrates and membranes of viruses replicated in vertebrates.

    ATTENUATED CHIKUNGUNYA VIRUS
    2.
    发明公开
    ATTENUATED CHIKUNGUNYA VIRUS 有权
    CH UN A。。。。。

    公开(公告)号：EP2900685A1

    公开(公告)日：2015-08-05

    申请号：EP13773563.5

    申请日：2013-09-26

    申请人： Research Development Foundation

    发明人： BROWN, Dennis, T. ,  HERNANDEZ, Raquel

    IPC分类号： C07K14/005 ,  A61K39/12

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C07K7/00 ,  C12N2770/36122 ,  C12N2770/36134

    摘要： Novel attenuating deletions of Chikungunya virus E2 polypeptides are provided as are attenuated viruses comprising the deletions. Also provided are immunogenic compositions comprising the attenuated viruses and methods of producing such viruses in cells (such as insect cells). Viruses of the embodiments can be used for immunization of animals to provide protection from the pathogenic effects of Chikungunya virus infection.

    摘要翻译： 提供基孔肯雅病毒E2多肽的新型减毒缺失是包含缺失的减毒病毒。 还提供了包含减毒病毒的免疫原性组合物和在细胞（如昆虫细胞）中产生这种病毒的方法。 实施方案的病毒可用于免疫动物以提供对基孔肯雅病毒感染的致病作用的保护。

    MEMBRANE VIRUS HOST RANGE MUTATIONS AND THEIR USES AS VACCINE SUBSTRATES
    6.
    发明授权
    MEMBRANE VIRUS HOST RANGE MUTATIONS AND THEIR USES AS VACCINE SUBSTRATES 有权
    FOR A WITSSPEKTRUM病毒膜突变及其作为VAKZINSUBSTRAT

    公开(公告)号：EP1037603B1

    公开(公告)日：2006-11-22

    申请号：EP98947150.3

    申请日：1998-09-18

    申请人： RESEARCH DEVELOPMENT FOUNDATION

    发明人： BROWN, Dennis, T. ,  HERNANDEZ, Racquel

    IPC分类号： A61K39/12 ,  C07K14/18

    CPC分类号： C07K14/005 ,  C12N7/00 ,  C12N2770/36122 ,  C12N2770/36161

    摘要： The vaccines and methods of the present invention are based on deletion mutations in the protein transmembrane domains of membrane-enveloped viruses. The strategy for production of these mutations is based on the fact that unlike mammalian cell membranes, the membranes of insect cells contain no cholesterol; thus are thinner than mammalian membranes. Many membrane-coated viruses have membrane glycoproteins on their surface which are responsible for identifying and infecting target cells. These membrane glycoproteins have hydrophobic membrane-spanning domains which anchor the proteins in the membrane bilayer. The membrane-spanning domains of these transmembrane proteins must be long enough to reach from one side of the bilayer to the other in order to hold the proteins in the membrane. Provided is a vaccine, a method of producing this vaccine, and a method of using this vaccine, based on the differences between membranes of viruses replicated in invertebrates and membranes of viruses replicated in vertebrates.