公开(公告)号：EP2897607A4

公开(公告)日：2016-10-05

申请号：EP13838498

申请日：2013-09-20

申请人： RHODE ISLAND HOSPITAL ,  UNIV MIDWESTERN

发明人： WANDS JACK R ,  DE LAMONTE SUZANNE ,  AIHARA ARIHIRO ,  OLSEN MARK JON ,  THOMAS JOHN-MICHAEL

IPC分类号： A61K31/341 ,  A61P35/00 ,  C07D307/32 ,  C07D307/66 ,  C07D405/12 ,  C07D409/04 ,  C07D417/04

CPC分类号： C07D417/04 ,  C07D307/32 ,  C07D307/66 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C12Q1/26

摘要： The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydroxylase (e.g., Asparatyl (asparaginyl) β-hydroxylase (ASPH)), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.