公开(公告)号：EP0501822A1

公开(公告)日：1992-09-02

申请号：EP92301725.5

申请日：1992-02-28

申请人： RHONE POULENC RORER LIMITED

发明人： Bridge, Andrew William

IPC分类号： C07F7/08 ,  A61K31/695

CPC分类号： C07F7/0818

摘要： Benzamide derivatives of the formula :

wherein R¹ is optionally substituted alkyl optionally containing double or triple bonds or cycloalkyl rings, which is interrupted by silicon, and optionally interrupted by a hetero atom, and/or by sulphinyl or sulphonyl groups, R² is hydrogen, alkyl, or optionally substituted phenyl or the two groups R² form a 3 to 8-membered ring, R³ is hydrogen or alkyl, R⁴ is alkoxy, alkylthio or dimethylamino, and R⁵ is a group -NR⁸R⁹ or -OR¹⁰ wherein R⁸ and R⁹ each represents hydrogen or alkyl optionally interrupted by a hetero atom, sulphinyl or sulphonyl group and optionally containing one or more carbon-carbon double or triple bonds, and R¹⁰ is alkyl optionally interrupted by a hetero atom, sulphinyl or sulphonyl group, and optionally containing double or triple bonds, or a pharmaceutically acceptable salt thereof, possess useful pharmacological properties.

摘要翻译： 下式的苯甲酰胺衍生物：其中R 1是任选地含有双键或三键或环烷基环的任选取代的烷基，被硅中断并且任选地被杂原子中断，和/或被亚磺酰基或磺酰基 R 2是氢，烷基或任选取代的苯基或两个基团R 2形成3至8元环，R 3是氢或烷基，R 4是烷氧基，烷硫基或二甲基氨基 ，R 5为基团-NR 8 R 9或-OR 1，其中R 8和R 9各自表示氢或任选被杂原子间隔的烷基，亚磺酰基 或磺酰基，并且任选地含有一个或多个碳 - 碳双键或三键，并且R 1是任选地被杂原子，亚磺酰基或磺酰基中间的烷基，并且任选地含有双键或三键或药学上 其可接受的盐具有有用的药理学性质。