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1.发明公开QUINOLINE AND QUINOXALINE COMPOUNDS WHICH INHIBIT PLATELET-DERIVED GROWTH FACTOR AND/OR P56?lck TYROSINE KINASES 失效喹啉和喹喔啉CONNECTIONS与血小板ABSTAMMMENDEN生长因子和/或PDGF和P56酪氨酸激酶抑制
公开(公告)号：EP0991628A1
公开(公告)日：2000-04-12
申请号：EP98925022.0
申请日：1998-05-28
IPC分类号： C07D241/44 , C07D405/10 , C07D215/20 , C07D215/38 , A61K31/47 , A61K31/495
CPC分类号： C07D215/38 , C07D215/20 , C07D241/42 , C07D241/44 , C07D241/52 , C07D241/54 , C07D403/04 , C07D405/12 , C07D453/06
摘要： This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56 tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.
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2.发明公开ARYL AND HETEROARYL QUINAZOLINE COMPOUNDS WHICH INHIBIT CSF-1R RECEPTOR TYROSINE KINASE 失效芳基和CSF-1R的HETEROARYLCHINAZOLINVERBINDUNGEN酪氨酸激酶受体INHIBIT
公开(公告)号：EP0871448A1
公开(公告)日：1998-10-21
申请号：EP95904308.0
申请日：1994-12-08
发明人： MYERS, Michael, R. , SPADA, Alfred, P. , MAGUIRE, Martin, P. , PERSONS, Paul, E. , ZILBERSTEIN, Asher , HSU, Chin-Yi, Jenny , JOHNSON, Susan, E.
IPC分类号： A61K31 , A61P19 , A61P35 , A61P37 , A61P39 , C07C43 , C07D213 , C07D215 , C07D239 , C07D241 , C07D265 , C07D277 , C07D401 , C07D403 , C07D405 , C07D409 , C07D471
CPC分类号： C07D213/30 , A61K31/517 , A61K31/5377 , C07C43/2055 , C07C43/225 , C07C43/23 , C07D213/64 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/233 , C07D215/50 , C07D239/74 , C07D239/88 , C07D239/91 , C07D239/93 , C07D239/94 , C07D241/42 , C07D241/52 , C07D265/22 , C07D277/64 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04
摘要： This invention relates to the modulation and/or inhibition of cell signaling, cell proliferation, cell inflammatory response, the control of abnormal cell growth and cell reproduction. More specifically, this invention relates to the use of mono- and/or bicyclic aryl or heteroaryl quinazoline compounds in inhibiting cell proliferation, including compounds which are useful protein tyrosine kinase (PTK) inhibitors. The method of treating cell proliferation and/or differentiation or mediator release using said quinazoline compounds and their use in pharmaceutical compositions is described.
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3.发明公开PROTEIN TYROSINE KINASE ARYL AND HETEROARYL QUINAZOLINE COMPOUNDS HAVING SELECTIVE INHIBITION OF HER-2 AUTOPHOSPHORYLATION PROPERTIES 失效具有选择性抑制HER-2自磷酸化特性的蛋白质酪氨酸激酶芳香化酶和杂芳基喹唑啉化合物
公开(公告)号：EP0831831A1
公开(公告)日：1998-04-01
申请号：EP96918362.0
申请日：1996-06-06
IPC分类号： C07D239 , A61K31 , A61P9 , A61P29 , A61P31 , A61P35 , A61P43 , C07C43 , C07D213 , C07D215 , C07D241 , C07D265 , C07D277 , C07D401 , C07D403 , C07D405 , C07D409 , C07D471
CPC分类号： C07C43/2055 , A61K31/517 , A61K31/5377 , C07C43/225 , C07C43/23 , C07D213/30 , C07D213/64 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/233 , C07D215/50 , C07D239/74 , C07D239/88 , C07D239/91 , C07D239/93 , C07D239/94 , C07D241/42 , C07D241/52 , C07D265/22 , C07D277/64 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04
摘要： This invention relates to a method for the selective treatment of cell growth and differentiation characterized by activity of the human epidermal growth factor receptor type 2 (HER2). More specifically, this invention relates to the use of substituted or unsubstituted mono- or bi-cyclic aryl, heteroaryl, cycloalkyl or heterocycloalkyl compounds in selectively regulating cell growth. Pharmaceutical compositions useful for the selective treatment of cell growth and differentiation are also described.
摘要翻译： 本发明涉及以人表皮生长因子受体2型（HER2）的活性为特征的选择性治疗细胞生长和分化的方法。 更具体地说，本发明涉及取代或未取代的单环或双环芳基，杂芳基，环烷基或杂环烷基化合物在选择性调节细胞生长中的用途。 还描述了用于选择性处理细胞生长和分化的药物组合物。
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4.发明公开PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE 失效吡唑并（3,4-G）喹喔啉ALS PDGF受体蛋白酪氨酸激酶抑制剂
公开(公告)号：EP0779889A1
公开(公告)日：1997-06-25
申请号：EP95932446.0
申请日：1995-09-06
CPC分类号： C07D487/04
摘要： This invention relates to pyrazolo[3,4-g]quinoxaline compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, compounds of this invention are novel as selective inhibitors of the PDGF-R protein tyrosine kinase and can be applied as potential therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation. Further, the present invention provides pharmaceutical compositions and a method for treating such disorders comprising the administration to a patient of a PDGF receptor inhibiting effective amount of a pyrazolo[3,4-g]quinoxaline compound exhibiting protein tyrosine kinase inhibition activity. Processes for the preparation of pyrazolo[3,4-g]quinoxaline compounds.
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