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1.发明公开Process for the preparation of angiotensin-II analogues substituted in the 1-, 5- and 8-positions 失效在1-，5-和8-位取代的血管紧张素II类似物的制备方法
公开(公告)号：EP0171270A3
公开(公告)日：1988-01-07
申请号：EP85305512
申请日：1985-08-02
发明人： Nyéki, Olga , Kisfaludy, Lajos , Szeberényi, Katalin , Makara, Gßbor , Varga, Bertalan , Kßrpßti, Egon , Szporny, Lßszl¾
摘要： The invention relates to octapeptides of the formula wherein
X is a sarcosyl, lactoyl or hydroxyacetyl radical, Y is cyclopentylglycyl or cyclohexylglycyl, and W is an aliphatic amino acid radical or lactic acid radical, having angiotensin-II antagonistic activity. A process for their preparation is also disclosed as are compositions containing them.-
公开(公告)号：EP0269389B1
公开(公告)日：1992-09-30
申请号：EP87310284.2
申请日：1987-11-20
发明人： Nyéki, Olga , Schön, István , Kisfaludy, Lajos , Dénes, Lászlò , Hajòs, György , Lapis, Károly , Szporny, Lászlò , Szende, Béla
CPC分类号： C07K5/06173 , A61K38/00 , C07K5/0815 , C07K5/0825 , C07K5/1019 , C07K5/1021
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3.发明公开Process for the preparation of angiotensin-II analogues substituted in the 1-, 5- and 8-positions 失效一种用于血管紧张素II类似物的制备方法，取代在位置1,5和8中。
公开(公告)号：EP0171270A2
公开(公告)日：1986-02-12
申请号：EP85305512.7
申请日：1985-08-02
发明人： Nyéki, Olga , Kisfaludy, Lajos , Szeberényi, Katalin , Makara, Gábor , Varga, Bertalan , Kárpáti, Egon , Szporny, László
摘要： The invention relates to octapeptides of the formula wherein
X is a sarcosyl, lactoyl or hydroxyacetyl radical,
Y is cyclopentylglycyl or cyclohexylglycyl, and W is an aliphatic amino acid radical or lactic acid radical, having angiotensin-II antagonistic activity.
A process for their preparation is also disclosed as are compositions containing them.-
公开(公告)号：EP0269389A3
公开(公告)日：1990-02-07
申请号：EP87310284.2
申请日：1987-11-20
发明人： Nyéki, Olga , Schön, István , Kisfaludy, Lajos , Dénes, Lászlò , Hajòs, György , Lapis, Károly , Szporny, Lászlò , Szende, Béla
CPC分类号： C07K5/06173 , A61K38/00 , C07K5/0815 , C07K5/0825 , C07K5/1019 , C07K5/1021
摘要： The new peptides of the Formulae (1) Glp-Lys-NH 2 (2) Glp-Glu-Lys-NH 2 (3) Arg-Lys-Glu-NH 2 (4) Arg-Lys-Asp-NH 2 (5) Arg-Lys-Glu-OH (6) Arg-Lys-Gln-OH (7) Leu-Val-Ala-OH (8) Arg-Orn-Asp-Val-NH 2 (9) Arg-Orn-Asp-Val-OH (10) Lys-Glu-Lys-Lys-OH (11) Lys-Leu-Lys-Lys-OH (12) Lys-Asp-Leu-Lys-OH (13) Glu-Leu-Val-Ala-OH and (14) Leu-Pro-Ala-Gly-OH
and acid addition salts thereof inhibit the proliferation of leukaemic cells and exhibit immunostimulant effect.摘要翻译： （1）Glp-Lys-NH 2（2）Glp-Glu-Lys-NH 2（3）Arg-Lys-Glu-NH 2（4）Arg-Lys-Asp-NH 2（5）Arg-Lys （8）Arg-Orn-Asp-Val-NH 2（9）Arg-Orn-Asp-Val-OH（10）Arg-Lys-Gln-OH ）Lys-Glu-Lys-Lys-OH（11）Lys-Leu-Lys-Lys-OH（12）Lys-Asp-Leu-Lys- Leu-Pro-Ala-Gly-OH及其酸加成盐抑制白血病细胞的增殖并表现出免疫刺激作用。
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公开(公告)号：EP0269389A2
公开(公告)日：1988-06-01
申请号：EP87310284.2
申请日：1987-11-20
发明人： Nyéki, Olga , Schön, István , Kisfaludy, Lajos , Dénes, Lászlò , Hajòs, György , Lapis, Károly , Szporny, Lászlò , Szende, Béla
CPC分类号： C07K5/06173 , A61K38/00 , C07K5/0815 , C07K5/0825 , C07K5/1019 , C07K5/1021
摘要： The new peptides of the Formulae (1) Glp-Lys-NH 2
(2) Glp-Glu-Lys-NH 2
(3) Arg-Lys-Glu-NH 2
(4) Arg-Lys-Asp-NH 2
(5) Arg-Lys-Glu-OH
(6) Arg-Lys-Gln-OH
(7) Leu-Val-Ala-OH
(8) Arg-Orn-Asp-Val-NH 2
(9) Arg-Orn-Asp-Val-OH
(10) Lys-Glu-Lys-Lys-OH
(11) Lys-Leu-Lys-Lys-OH
(12) Lys-Asp-Leu-Lys-OH
(13) Glu-Leu-Val-Ala-OH and
(14) Leu-Pro-Ala-Gly-OH
and acid addition salts thereof inhibit the proliferation of leukaemic cells and exhibit immunostimulant effect.摘要翻译： 式（1）的新肽Glp-Lys-NH 2（2）Glp-Glu-Lys-NH 2（3）Arg-Lys-Glu-NH 2（4）Arg-Lys-Asp-NH 2（5）Arg-Lys -Glu-OH（6）Arg-Lys-Gln-OH（7）Leu-Val-Ala-OH（8）Arg-Orn-Asp-Val-NH2（9）Arg-Orn-Asp-Val-OH ）Lys-Glu-Lys-Lys-OH（11）Lys-Leu-Lys-Lys-OH（12）Lys-Asp-Leu-Lys-OH（13）Glu-Leu-Val-Ala-OH和（14） Leu-Pro-Ala-Gly-OH及其酸加成盐抑制白血病细胞的增殖并表现出免疫刺激作用。
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