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公开(公告)号：EP0178176A3
公开(公告)日：1988-03-23
申请号：EP85307264
申请日：1985-10-10
发明人： Vezert, Csilla , Tegyey, Zsuzsanna , Cholnoky, Eszter , Urogdi, Laszlo , Tudos, Helga , Szporny, Laszlo , Kisfaludy, Lajos , Palosi, Eva , Otvos, Laszlo , Ronai, Sara
IPC分类号： C07D273/04 , A61K31/535 , C07C153/057
CPC分类号： C07D273/04
摘要： 57 The present invention relates to optically active or racemic tetrahydro-1,2,4-oxadiazine-5-thione derivatives, to methods for their preparation, and pharmaceutical compositions containing the said compounds. Methods for the anticonvulsive treatment of mammals, especially human beings are described. The compounds of the formula I have similar activity to diphenyl hydantoin but their toxicity is much lower.
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公开(公告)号：EP0178176B1
公开(公告)日：1992-01-02
申请号：EP85307264.3
申请日：1985-10-10
申请人： RICHTER GEDEON VEGYESZETI GYAR R.T. , Magyar Tudomanyos Akadémia Központi Kémiai Kutato Intézete
发明人： Vezert, Csilla , Tegyey, Zsuzsanna , Cholnoky, Eszter , Urogdi, Laszlo , Tudos, Helga , Szporny, Laszlo , Kisfaludy, Lajos , Palosi, Eva , Otvos, Laszlo , Ronai, Sara
IPC分类号： C07D273/04 , A61K31/535 , C07C327/42
CPC分类号： C07D273/04
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公开(公告)号：EP0178176A2
公开(公告)日：1986-04-16
申请号：EP85307264.3
申请日：1985-10-10
申请人： RICHTER GEDEON VEGYESZETI GYAR R.T. , Magyar Tudomanyos Akadémia Központi Kémiai Kutato Intézete
发明人： Vezert, Csilla , Tegyey, Zsuzsanna , Cholnoky, Eszter , Urogdi, Laszlo , Tudos, Helga , Szporny, Laszlo , Kisfaludy, Lajos , Palosi, Eva , Otvos, Laszlo , Ronai, Sara
IPC分类号： C07D273/04 , A61K31/535 , C07C327/42
CPC分类号： C07D273/04
摘要： 57 The present invention relates to optically active or racemic tetrahydro-1,2,4-oxadiazine-5-thione derivatives, to methods for their preparation, and pharmaceutical compositions containing the said compounds. Methods for the anticonvulsive treatment of mammals, especially human beings are described.
The compounds of the formula I have similar activity to diphenyl hydantoin but their toxicity is much lower.
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