专利检索 ap:("RICHTER GEDEON VEGYESZETI GYAR R.T." OR "Magyar Tudomanyos Akadémia Központi Kémiai Kutato Intézete") AND inv:"Otvos, Laszlo" 第 1 页

1.

发明授权
Tetrahydro-1,2,4-oxadiazine-5-thione derivatives 失效
标题翻译：四氢-1,2,4-氧杂环丁烷-5-基衍生物

公开(公告)号：EP0178176B1

公开(公告)日：1992-01-02

申请号：EP85307264.3

申请日：1985-10-10

申请人： RICHTER GEDEON VEGYESZETI GYAR R.T. , Magyar Tudomanyos Akadémia Központi Kémiai Kutato Intézete

发明人： Vezert, Csilla , Tegyey, Zsuzsanna , Cholnoky, Eszter , Urogdi, Laszlo , Tudos, Helga , Szporny, Laszlo , Kisfaludy, Lajos , Palosi, Eva , Otvos, Laszlo , Ronai, Sara

IPC分类号： C07D273/04 , A61K31/535 , C07C327/42

CPC分类号： C07D273/04

2.

发明公开
Tetrahydro-1,2,4-oxadiazine-5-thione derivatives 失效
标题翻译：四氢1,2,4-恶二嗪-5-硫酮酯衍生物。

公开(公告)号：EP0178176A2

公开(公告)日：1986-04-16

申请号：EP85307264.3

申请日：1985-10-10

申请人： RICHTER GEDEON VEGYESZETI GYAR R.T. , Magyar Tudomanyos Akadémia Központi Kémiai Kutato Intézete

发明人： Vezert, Csilla , Tegyey, Zsuzsanna , Cholnoky, Eszter , Urogdi, Laszlo , Tudos, Helga , Szporny, Laszlo , Kisfaludy, Lajos , Palosi, Eva , Otvos, Laszlo , Ronai, Sara

IPC分类号： C07D273/04 , A61K31/535 , C07C327/42

CPC分类号： C07D273/04

摘要： 57 The present invention relates to optically active or racemic tetrahydro-1,2,4-oxadiazine-5-thione derivatives, to methods for their preparation, and pharmaceutical compositions containing the said compounds. Methods for the anticonvulsive treatment of mammals, especially human beings are described.
The compounds of the formula I have similar activity to diphenyl hydantoin but their toxicity is much lower.

3.

发明公开
Tetrahydro-1,2,4-oxadiazine-5-thione derivatives 失效
标题翻译：四氢-1,2,4-氧杂环丁烷-5-基衍生物

公开(公告)号：EP0178176A3

公开(公告)日：1988-03-23

申请号：EP85307264

申请日：1985-10-10

申请人： RICHTER GEDEON VEGYESZETI GYAR R.T. , MTA Központi Kémiai Kutato Intézete

发明人： Vezert, Csilla , Tegyey, Zsuzsanna , Cholnoky, Eszter , Urogdi, Laszlo , Tudos, Helga , Szporny, Laszlo , Kisfaludy, Lajos , Palosi, Eva , Otvos, Laszlo , Ronai, Sara

IPC分类号： C07D273/04 , A61K31/535 , C07C153/057

CPC分类号： C07D273/04

摘要： 57 The present invention relates to optically active or racemic tetrahydro-1,2,4-oxadiazine-5-thione derivatives, to methods for their preparation, and pharmaceutical compositions containing the said compounds. Methods for the anticonvulsive treatment of mammals, especially human beings are described. The compounds of the formula I have similar activity to diphenyl hydantoin but their toxicity is much lower.