专利检索 ap:("RIJKSUNIVERSITEIT GRONINGEN" OR "Academisch Ziekenhuis Groningen" OR "UMC Utrecht Holding B.V.") AND inv:"MULDER, Douwe Johannes" 第 1 页

1.

发明公开
ORAL DOSAGE FORMS OF ACID-LABILE SALT AND METHODS AND USES RELATED THERETO 审中-公开

公开(公告)号：EP4212149A1

公开(公告)日：2023-07-19

申请号：EP22151974.7

申请日：2022-01-18

申请人： RIJKSUNIVERSITEIT GRONINGEN , Academisch Ziekenhuis Groningen , UMC Utrecht Holding B.V.

发明人： FRIJLINK, Henderik Willem , EISSENS, Anko Cornelus , VAN GOOR, Harm , MULDER, Douwe Johannes , JOLES, Jacob Alexander

IPC分类号： A61K9/20 , A61K9/28

摘要： The invention relates to the field of oral drug delivery and more in particular, to oral dosage forms for delivery of a high dose of a therapeutically active acid-labile salt, such as sodium thiosulfate (STS). Provided is a pharmaceutical oral dosage form for controlled delivery of an acid-labile salt, the dosage form comprising a core comprising the acid-labile salt in a polymer matrix comprising a combination of (i) a pH-sensitive hydrophilic methacrylic acid-methyl methacrylate copolymer and (ii) a carbomer, wherein the acid-labile salt makes up at least 50wt% of the core; and wherein the outer surface of the core is provided with an enteric coating layer.