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公开(公告)号：EP0810281A2
公开(公告)日：1997-12-03
申请号：EP97303594.2
申请日：1997-05-27
发明人： Endo, Isao , Nagamune, Teruyuki , Inoue, Kozo , Kawamura, Kinichi
IPC分类号： C12M1/34
CPC分类号： C12M23/00 , C12M41/00 , Y10S435/817
摘要： A detecting apparatus (1) is disclosed, that comprises a plurality of measurement devices (7-11) with respective sensors (e.g. 7a, 7b) and supporting means (2) for holding the measurement devices in such a manner that the individual sensors can, when the apparatus is affixed to a bio-reactor, contact a culture broth; the turbidity, dissolved oxygen, dissolved carbon dioxide, temperature, pH, and similar or other internal environmental conditions of the culture broth being obtained by these measurement devices. Use of such a device enables the physiological activity of the organism in the culture broth to be monitored, whilst reducing the risk of ingress of foreign matter to the interior of a bio-reactor whilst simultaneously reducing disruption to the liquid flow within a bio-reactor fitted with this detecting apparatus.
摘要翻译： 公开了一种检测装置（1），其包括具有相应传感器（例如7a，7b）的多个测量装置（7-11）和用于以这样的方式保持测量装置的支撑装置（2），即，各个传感器可以 当将该装置固定在生物反应器上时，接触培养液; 通过这些测量装置获得的培养液的浊度，溶解氧，溶解二氧化碳，温度，pH以及类似或其它内部环境条件。 使用这种装置能够监测培养液中的生物的生理活性，同时降低异物进入生物反应器内部的风险，同时减少生物反应器内液体流动的破坏 装配有该检测装置。
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公开(公告)号：EP0244873A3
公开(公告)日：1988-12-21
申请号：EP87106710
申请日：1987-05-08
摘要： A cell culture method proliferates microorganisms, particularly fungi such as molds, actinomycetes, animal cells, plant cells and so on to produce useful substances such as antibiotics, enzymes, proteins, polysaccharides, physiological active substances, and animal and plant hormones. Porous material including the medium and cells to be proliferated is moved, whereby air is supplied to the surface of the porous material.
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公开(公告)号：EP0244873B1
公开(公告)日：1992-08-05
申请号：EP87106710.4
申请日：1987-05-08
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公开(公告)号：EP0295567A1
公开(公告)日：1988-12-21
申请号：EP88109151.6
申请日：1988-06-08
发明人： Endo, Isao , Nagamune, Teruyuki , Tachikawa, Susumu , Seike, Yasuhiro , Inaba, Hideki , Kurusu, Haruo
IPC分类号： C12M1/12
CPC分类号： B01J19/2435 , C12M23/06 , C12M29/16
摘要： A tubular bioreactor containing fluidized biocatalyst(s), which has a structure of a tubular circuit in a closed loop, comprising porous tubular membrane module(s) (1) constituting at least a portion of the tubular circuit, through which membrane product(s) may pass or permeate;
a tubular hollowed member coaxial about and spaced from the said membrane module, which tubular part has an outlet(s) (5) for discharging the product(s) from the tubular circuit structure;
an inlet (4) for feeding substrate(s), which inlet may be mounted on the wall of the below mentioned connecting tubing(s);
a means for circulating the said mixture flow containing a substrate(s), the biocatalyst(s), and the product(s), in the said tubular circuit structure; and
tubing(s) connecting the said membrane module and the said circulating means.摘要翻译： 包含流化生物催化剂的管状生物反应器，其具有闭合回路中的管状回路的结构，包括构成管状回路的至少一部分的多孔管状膜组件（1），通过该多孔管状膜组件，膜产物 ）可能通过或渗透; 管状中空部件与所述膜组件相隔并且间隔开，所述管状部件具有用于将所述产品从所述管状电路结构排出的出口（5）。 用于供给基底的入口（4），该入口可以安装在下述连接管的壁上; 用于在所述管状电路结构中循环含有基底，所述生物催化剂和所述产物的所述混合物流的装置; 以及连接所述膜组件和所述循环装置的管道。
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公开(公告)号：EP0295567B1
公开(公告)日：1994-10-12
申请号：EP88109151.6
申请日：1988-06-08
发明人： Endo, Isao , Nagamune, Teruyuki , Tachikawa, Susumu , Seike, Yasuhiro , Inaba, Hideki , Kurusu, Haruo
IPC分类号： C12M1/12
CPC分类号： B01J19/2435 , C12M23/06 , C12M29/16
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公开(公告)号：EP0269086A3
公开(公告)日：1989-09-20
申请号：EP87117395.1
申请日：1987-11-25
CPC分类号： C12M25/20
摘要： A cell culture apparatus is described which comprises a fluidized bed culture tank body in which cell attached porous material is fluidized by air flow, and a pre-culture tank for supplying medium to said fluidized bed culture tank body corresponding to the amount of the liquid medium which is taken out of said fluidized bed culture tank body. The cell culture apparatus can be used for the continuous production of a metabolite.
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公开(公告)号：EP0244873A2
公开(公告)日：1987-11-11
申请号：EP87106710.4
申请日：1987-05-08
摘要： A cell culture method proliferates microorganisms, particularly fungi such as molds, actinomycetes, animal cells, plant cells and so on to produce useful substances such as antibiotics, enzymes, proteins, polysaccharides, physiological active substances, and animal and plant hormones. Porous material including the medium and cells to be proliferated is moved, whereby air is supplied to the surface of the porous material.
摘要翻译： 细胞培养方法增殖微生物，特别是真菌如霉菌，放线菌，动物细胞，植物细胞等，以产生有用的物质，如抗生素，酶，蛋白质，多糖，生理活性物质和动植物激素。 包括培养基和增殖细胞的多孔材料被移动，由此向多孔材料的表面供应空气。
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公开(公告)号：EP0269086A2
公开(公告)日：1988-06-01
申请号：EP87117395.1
申请日：1987-11-25
CPC分类号： C12M25/20
摘要： A cell culture apparatus is described which comprises a fluidized bed culture tank body in which cell attached porous material is fluidized by air flow, and a pre-culture tank for supplying medium to said fluidized bed culture tank body corresponding to the amount of the liquid medium which is taken out of said fluidized bed culture tank body. The cell culture apparatus can be used for the continuous production of a metabolite.
摘要翻译： 描述了一种细胞培养装置，其包括其中细胞附着的多孔材料通过气流流化的流化床培养箱体，以及用于向所述流化床培养罐体供给培养基的预培养罐，其对应于液体培养基的量 其从所述流化床培养罐体中取出。 细胞培养装置可用于连续生产代谢物。
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