公开(公告)号：EP4217464B1

公开(公告)日：2024-05-22

申请号：EP21801685.5

申请日：2021-09-22

IPC: C12N5/00

CPC classification number: C12M47/04 ,  C12M25/16 ,  C12N5/0012 ,  C12N5/0006 ,  C12N2537/1020130101

公开(公告)号：EP3155087A4

公开(公告)日：2018-01-24

申请号：EP11807444

申请日：2011-07-13

Applicant: NANOPHARMACEUTICALS LLC ,  LIN HUNG-YUN ,  DRUSANO GEORGE ,  LOUIE ARNOLD ,  DAVIS PAUL J

Inventor： LIN HUNG-YUN ,  DRUSANO GEORGE ,  LOUIE ARNOLD ,  DAVIS PAUL J

IPC: C12M3/02 ,  C12M1/00 ,  C12M1/12 ,  C12M1/24 ,  C12N5/09 ,  C12Q1/04 ,  G01N33/15 ,  G01N33/50

CPC classification number: C12M25/10 ,  C12M23/08 ,  C12M23/26 ,  C12M25/16 ,  C12N5/0693 ,  C12N2513/00 ,  C12N2531/00 ,  G01N33/5011 ,  G01N2800/52

Abstract: Provided herein is a continuous cell perfusion model system that provides useful pharmacokinetic and pharmacodynamic information on the application of new drugs or combinations of various agents in vitro to human cancer cell lines. Also provided are methods of using this system to individualize cancer treatment.

公开(公告)号：EP3201308A1

公开(公告)日：2017-08-09

申请号：EP15781045.8

申请日：2015-09-30

Applicant: Dong Energy Thermal Power A/S

Inventor： ULLER, Bjarne

IPC: C12M1/107 ,  C12M1/12 ,  C12M1/00

CPC classification number: C12M21/04 ,  C12M25/16 ,  C12M27/20 ,  Y02E50/343

Abstract: The invention relates to methods, devices and inserts for reactors for microbial and anaerobic digestion. In particular, the invention relates to reactors comprising inserts for biofilms, such as methane-producing biofilms, immobilized on a carrier matrix.

Abstract translation: 本发明涉及用于微生物和厌氧消化的反应器的方法，装置和插入物。 具体而言，本发明涉及包含固定在载体基质上的用于生物膜的插件的反应器，所述插件例如产生甲烷的生物膜。

公开(公告)号：EP3141595A1

公开(公告)日：2017-03-15

申请号：EP15184910.6

申请日：2015-09-11

Applicant: pro agri gmbh

Inventor： Beckers, Klaus

IPC: C12M1/107 ,  C12M3/00 ,  C12M1/12 ,  C12M1/00 ,  C12M1/34 ,  C12M1/02 ,  C12M1/33 ,  A23N1/00 ,  C02F11/00

CPC classification number: C12M21/04 ,  C02F11/00 ,  C02F11/04 ,  C12M23/44 ,  C12M25/16 ,  C12M29/26 ,  C12M41/16 ,  C12M41/18 ,  C12M45/02 ,  C12M45/07 ,  Y02E50/343

Abstract: Offenbart wird ein Verfahren zum Erzeugen von Biogas durch Vergärung von pumpfähigen organischen Ausgangsmaterialien, insbesondere von Güllen und Jauchen aus der Tierhaltung, wobei
- ein Zustrom des organischen Ausgangsmaterials aufgeteilt wird in einen Dickstoffanteil mit gegenüber dem Ausgangsmaterial höherem Feststoffanteil und einen flüssigkeitsdominierten Dünnstoffanteil mit gegenüber dem Ausgangsmaterial geringerem Feststoffanteil,
- der Dünnstoffanteil einem Dünnstofffermenter (23), in dem Mikroorganismen auf in dem Füllvolumen des Dünnstofffermenters (23) in der Schwebe gehaltenen Aufwuchskörpern (27) aufgewachsen sind, zugeführt und dort fermentiert wird,
- in dem Dünnstofffermenter (23) entstandenes Biogas aufgefangen und für eine weitere Verwendung abgeführt wird,
- in dem Dünnstofffermenter (23) entstehende Gärreste abgeführt werden.
Dieses Verfahren erlaubt den Betrieb von kompakten und zu günstigen Investitionskosten herzurichtenden Anlagen zur Biogasgewinnung. Eine hier ebenfalls offenbarte Vorrichtung zum Erzeugen von Biogas nach dem Verfahren ist insbesondere modular aufgebaut mit straßentransportfähigen Modulen.

Abstract translation: 公开的是由可泵送有机起始原料，特别是泥浆和泥浆从畜牧业，其中的厌氧消化产生沼气的方法 - 的有机原料的流入相对于分离成浓稠浆料成分起始材料高固相率，并且相对于起始原料的液体占主导地位的薄材料部分 较低的固体含量， - 保持在其中在悬浮液中生长的身体的薄坯发酵罐（23）（27）的填充体积的微生物被升高，供给和发酵在其中一个薄的材料蒸煮（23）的薄材料部分， - 在稀浆发酵产生量（23）的沼气 被收集和排出以供进一步使用， - 导致薄坯发酵罐（23）消化消散。 这种方法允许对沼气厂紧凑herzurichtenden低投资成本的操作。 根据该方法产生的沼气甲这里还公开了装置处于特定的模块化设计，道路运输的模块。

公开(公告)号：EP2536819A4

公开(公告)日：2017-01-25

申请号：EP11745150

申请日：2011-02-16

Applicant: UNIV NORTH CAROLINA CHAPEL HILL

Inventor： ALLBRITTON NANCY ,  SIMS CHRISTOPHER ,  WANG YULI

IPC: C12M1/00 ,  B01J19/00 ,  C12M1/12 ,  C12M1/32 ,  C12M3/00

CPC classification number: C12M23/12 ,  B01J19/0046 ,  B01J2219/00452 ,  B01J2219/00743 ,  C12M23/20 ,  C12M23/22 ,  C12M25/04 ,  C12M25/16 ,  C12M47/02 ,  C12M47/04

Abstract: An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe).

公开(公告)号：EP3098304A1

公开(公告)日：2016-11-30

申请号：EP15169593.9

申请日：2015-05-28

Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

Inventor： Confalonrieri, Davide ,  Hansmann, Jan ,  Walles, Heike ,  Krziminski, Steffan

IPC: C12N5/00 ,  C12M1/22 ,  C12M1/32 ,  C12M1/12 ,  C12N5/0775

CPC classification number: C12N5/0075 ,  C12M23/04 ,  C12M23/10 ,  C12M25/14 ,  C12M25/16 ,  C12N5/0068 ,  C12N5/0663 ,  C12N2502/28 ,  C12N2533/54 ,  C12N2535/00

Abstract: The present invention relates to a hybrid cell culturing system, a process for culturing cells using said hybrid cell culturing system, a cell culture device comprising said hybrid cell culturing system and use of at least one second cell culturing support designed to be arranged to at least one arrangement position of a first cell culturing support for culturing cells.

Abstract translation: 本发明涉及一种混合细胞培养系统，用于培养使用所述混合细胞培养系统的细胞的过程中，细胞培养装置包括在所述混合细胞培养系统和用至少一个第二细胞培养支持设计的，以被设置为至少 用于培养细胞的第一细胞培养载体的一个配置位置。

公开(公告)号：EP3080280A1

公开(公告)日：2016-10-19

申请号：EP13899115.3

申请日：2013-12-13

Applicant: Microvi Biotech Inc.

Inventor： RAZAVI-SHIRAZI, Fatemeh ,  DORRI, Mohammad, Ali ,  RAZAVI, Ameen (NMN)

IPC: C12P1/00 ,  C12N11/02

CPC classification number: C12N11/02 ,  C12M25/16 ,  C12N11/04 ,  C12P1/00 ,  C12P7/06 ,  Y02E50/17

Abstract: Processes are disclosed for bioconversion processes in which a ME biocatalyst is surrounded by water-insoluble liquid during the bioconversion to facilitate one or more of mass transfer of substrate to and bioproduct from the biocatalyst and the separation and recovery of bioproduct from the water-insoluble liquid. The ME biocatalyst irreversibly retains microorganisms for the bioconversion and has, in its interior, an aqueous environment.

Abstract translation: 公开了用于生物转化过程的方法，其中ME生物催化剂在生物转化期间被水不溶性液体包围，以促进底物的质量转移和生物催化剂的生物产物的一个或多个以及从水不溶性液体分离和回收生物产物 。 ME生物催化剂不可逆地保留用于生物转化的微生物，并且在其内部具有水性环境。

公开(公告)号：EP2928900A4

公开(公告)日：2016-08-03

申请号：EP13860076

申请日：2013-11-20

Applicant: 3M INNOVATIVE PROPERTIES CO

Inventor： GRIESGRABER GEORGE W ,  FITZSIMONS ROBERT T JR ,  HANGGI DOUGLAS A ,  NAKAMURA MASAYUKI ,  RASMUSSEN JERALD K

IPC: C07F7/10 ,  B01J2/08 ,  B01J20/10 ,  B01J20/32 ,  C07C279/04 ,  C07F7/18 ,  G01N1/40

CPC classification number: C07F7/1836 ,  B01D15/00 ,  B01D24/00 ,  B01J20/103 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/286 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3244 ,  B01J20/3293 ,  B01J2220/80 ,  C07F7/1872 ,  C07F7/1892 ,  C12M25/16 ,  G01N1/405

Abstract: Guanidine-functionalized particles and methods of making and using such particles.

Abstract translation: 胍基官能化颗粒及其制备和使用搜索颗粒的方法。

公开(公告)号：EP3020798A1

公开(公告)日：2016-05-18

申请号：EP14823551.8

申请日：2014-07-08

Applicant: Universal Bio Research Co., Ltd.

Inventor： TAJIMA Hideji ,  UEDA Tetsuya

IPC: C12M3/00 ,  C12M1/00 ,  C12N1/00 ,  C12N5/071

CPC classification number: C12M35/06 ,  C12M23/04 ,  C12M25/16 ,  C12M27/16 ,  C12M33/00 ,  C12M41/00 ,  C12M41/14 ,  C12N13/00

Abstract: This culture device (10) comprises: a culture container (10) which houses cells, magnetic particles and a culture medium; a temperature adjustment unit (5) for adjusting the temperature of the culture container (10); a magnet (7a) which is provided to the outside of the culture container (10); a magnetic force adjustment unit (7b) for adjusting the magnetic force of the magnet (7a); and a control unit for controlling the operation of the magnetic force adjustment unit (7b). The magnetic force adjustment unit (7b) adjusts the magnetic force of the magnet (7b), thereby holding magnetic particles and cells in a predetermined region within the culture container (10), or dispersing the magnetic particles and cells within the culture container.

公开(公告)号：EP2981604A1

公开(公告)日：2016-02-10

申请号：EP14799564.1

申请日：2014-10-01

Applicant: Uniwersytet Warmi Sko-Mazurski W Olsztynie

Inventor： KRZEMIENIEWSKI, Miroslaw ,  DEBOWSKI, Marcin ,  ZIELINSKI, Marcin

IPC: C12M1/00 ,  B01D53/62 ,  C12M1/12

CPC classification number: C12M21/02 ,  B01D53/62 ,  B01D53/84 ,  B01D2251/95 ,  B01D2257/504 ,  B01D2258/0275 ,  B01D2258/0283 ,  B01D2258/05 ,  B01D2259/802 ,  C12M25/16 ,  C12M31/10 ,  C12M43/04 ,  Y02A50/2358 ,  Y02C10/02 ,  Y02C10/04 ,  Y02P20/59

Abstract: A photobioreactor for CO2 biosequestration according to the invention has a biomass of algae or cyanobacteria immobilised in capsules (3) which have an outer envelope (4). The capsules of the biomass of algae or cyanobacteria (3) are supplied with light from a light source (6) by a separate, single light tube (5). In the photobioreactor, the capsules (3) are surrounded by a gaseous atmosphere and are wetted with a culture medium and periodically flushed. The photobioreactor is polyhedral or circular in its cross section.

Abstract translation: 根据本发明的用于CO 2生物鉴别的光生物反应器具有固定在具有外封套（4）的胶囊（3）中的藻类或蓝细菌的生物质。 通过单独的单个光管（5）向藻类或蓝细菌（3）的生物质的胶囊供应来自光源（6）的光。 在光生物反应器中，胶囊（3）被气体环境包围，并用培养基润湿并周期性地冲洗。 光生物反应器的横截面为多面体或圆形。