公开(公告)号：EP3077050A4

公开(公告)日：2017-11-01

申请号：EP14866961

申请日：2014-12-04

申请人： RXI PHARMACEUTICALS CORP

发明人： CAUWENBERGH GERARD ,  PAVCO PAMELA A ,  LIBERTINE LYN ,  BULOCK KAREN G ,  CARDIA JAMES

IPC分类号： A61P17/02 ,  A61K31/7125 ,  A61K31/713 ,  C12N15/11

CPC分类号： C12N15/1136 ,  A61K9/0014 ,  A61K9/0021 ,  A61K9/0048 ,  A61K31/7088 ,  A61K31/7125 ,  A61K31/713 ,  A61K47/60 ,  C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2320/31 ,  C12N2320/32 ,  C12N2320/35 ,  A61K2300/00

摘要： The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal and fibrotic applications. Aspects of the invention provide nucleic acid molecules for the prophylactic treatment of wounding to reduce scarring. Herein, it is demonstrated that a specific nucleic acid molecule, RXI-109 (targeting connective tissue growth factor (CTGF)), given prophylactically, reduces scarring during wound healing.

公开(公告)号：EP3137119A4

公开(公告)日：2018-05-09

申请号：EP15785528

申请日：2015-04-28

申请人： RXI PHARMACEUTICALS CORP

发明人： BYRNE MICHAEL ,  BULOCK KAREN G ,  CARDIA JAMES

IPC分类号： A61K48/00

CPC分类号： C12N15/1135 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/3515 ,  C12N2310/53 ,  C12N2320/32 ,  C12N2320/35

摘要： Aspects of the invention relate to methods for treating cancer by administering to a subject in need thereof a therapeutically effective amount of a nucleic acid molecule that is directed against a gene encoding mouse double minute 1 homolog (MDM1), mouse double minute 2 homolog (MDM2), mouse double minute 3 homolog (MDM3), mouse double minute 4 homolog (MDM4) or V-myc myelocytomatosis viral related oncogene (MYCN) for treating cancer. Further aspects of the invention relate to nucleic acid molecules and compositions comprising nucleic acid molecules.

公开(公告)号：EP3137118A4

公开(公告)日：2017-11-22

申请号：EP15785216

申请日：2015-05-01

申请人： RXI PHARMACEUTICALS CORP

发明人： BYRNE MICHAEL ,  PAVCO PAMELA A ,  BULOCK KAREN G

IPC分类号： A61K48/00 ,  C07H21/02 ,  C12N15/113

CPC分类号： C12N15/1137 ,  A61K31/7088 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/34 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2310/3521 ,  C12N2310/3533 ,  C12N2320/32 ,  C12N2320/51 ,  C12N2320/52

摘要： Aspects of the invention relate to methods for treating an ocular disorder associated with the front of the eye, comprising administering to the eye of a subject in need thereof a therapeutic RNA molecule, in an effective amount to treat an ocular disorder associated with the front of the eye.