公开(公告)号：EP3125924A1

公开(公告)日：2017-02-08

申请号：EP15774029.1

申请日：2015-03-30

申请人： Ramot at Tel-Aviv University Ltd. ,  Mor Research Applications Ltd.

发明人： SHALGI, Ruth ,  CHUDERLAND, Dana ,  BAR-JOSEPH, Hadas ,  GOLDBERG, Keren ,  BEN-AHARON, Irit ,  STEMMER, Salomon M.

IPC分类号： A61K38/18 ,  A61P15/08 ,  A61K31/138

CPC分类号： A61K38/18 ,  A61K31/138 ,  A61K31/704 ,  C12N5/0609 ,  C12N2501/10 ,  G01N33/74 ,  G01N2333/475 ,  G01N2800/34 ,  G01N2800/36 ,  G01N2800/52 ,  G01N2800/709 ,  A61K2300/00

摘要： A method of treating or preventing gonadal or uterine toxicity induced by an agent in a subject is provided. Accordingly there is provided a method comprising administering to a subject a therapeutically effective amount of pigment epithelium-derived factor (PEDF), thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is, a method comprising determining gonadal function in a subject; and administering to the subject a therapeutically effective amount of PEDF, thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is a PEDF for use in the treatment or prevention of gonadal toxicity induced by an agent in a subject. Also provided are cell culture, a medium, a kit and method for improving oocyte quality ex-vivo.

摘要翻译： 提供治疗或预防由一种在对象中诱导剂性腺或子宫毒性的方法。 因此，提供包括给予受试者治疗有效量的色素上皮衍生因子（PEDF），从而治疗或预防由该试剂引起的性腺毒性的方法。 所以，提供的是，包括在主题确定采矿性腺功能的方法; 和给予所述受试者治疗有效量的PEDF，从而治疗或预防由药物引起的性腺毒性。 这样提供了用于通过在受试者中诱导剂性腺毒性的治疗或预防中使用的PEDF。 所以提供了细胞培养物，介质，试剂盒和用于提高卵母细胞质量体外方法。