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公开(公告)号：EP4370661A1
公开(公告)日：2024-05-22
申请号：EP22747390.7
申请日：2022-07-14
申请人： Shah Caviar Limited
发明人： BENNING, Kenneth
IPC分类号： C12N5/076 , C12N5/0735 , C12N5/075 , C12N5/071
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公开(公告)号：EP3412767A1
公开(公告)日：2018-12-12
申请号：EP16888751.1
申请日：2016-02-04
发明人： WU, Ji
IPC分类号： C12N5/074
CPC分类号： C12N5/0609 , C12N2533/54 , C12N2537/00 , G01N33/56966 , G01N2333/914
摘要： Provided is a method for obtaining female germline stem cells from follicular aspirates.
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公开(公告)号：EP2987855B1
公开(公告)日：2018-11-21
申请号：EP15168666.4
申请日：2005-05-17
CPC分类号： C12N5/0611 , A61B17/43 , A61K35/14 , A61K35/28 , A61K2035/124 , C12N5/0609 , C12N5/0634 , C12N2506/11 , C12P21/06
摘要： The present invention relates to methods of isolation of female germline stem cells and their progenitors.
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公开(公告)号：EP2155861B1
公开(公告)日：2018-09-05
申请号：EP08742643.3
申请日：2008-04-07
IPC分类号： C12N5/0735
CPC分类号： C12N5/0606 , A61K35/545 , C12N5/0609 , C12N2500/02 , C12N2500/14 , C12N2501/115 , C12N2501/235 , C12N2502/1323
摘要： Methods are disclosed for generating HLA homozygous parthenogenetic human stem cell (hpSC-Hhom) lines from both HLA homozygous and HLA heterozygous donors. These hpSC-Hhom lines demonstrate typical human embryonic stem cell morphology, expressing appropriate stem cell markers and possessing high levels of alkaline phosphatase and telomerase activity. Additionally, injection of these cell lines into immunodeficient animals leads to teratoma formation. Furthermore, in the case of HLA heterozygous donors, the hpSC-Hhom lines inherit the haplotype from only one of the donor's parents. SNP data analysis suggests that hpSC-Hhom lines derived from HLA heterozygous oocyte donors are homozygous throughout the genome as assessed by single-nucleotide polymorphism (SNP) analysis. The protocol as disclosed minimizes the use of animal-derived components, which makes the stem cells more practical for clinical application.
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公开(公告)号：EP3191117A4
公开(公告)日：2018-05-02
申请号：EP15840263
申请日：2015-09-09
发明人： CHENG YUAN , HSUEH AARON J W
IPC分类号： A61K38/17 , A61K31/36 , A61K31/365 , A61K31/5377 , A61K38/24 , A61K38/54 , A61K45/06 , A61P15/08
CPC分类号： A61K38/24 , A61K31/36 , A61K31/365 , A61K31/53 , A61K31/5377 , A61K35/54 , A61K45/06 , C12N5/0609 , C12N5/0682 , C12N2501/04 , C12N2501/727 , A61K2300/00
摘要： Methods are provided for stimulating ovarian follicles in a mammal through activation of the mTor signaling pathway.
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公开(公告)号：EP3165187A4
公开(公告)日：2018-03-14
申请号：EP15818614
申请日：2015-07-02
发明人： PENG JIANJUN
IPC分类号： A61B17/435 , A61D19/04 , B01L3/02
CPC分类号： C12N5/0609 , A61B17/435 , A61D19/04 , B01L3/0227 , B01L3/0237 , B01L2200/0684 , C12M21/06 , C12M41/48 , C12M45/02 , C12M45/09 , C12M47/04 , C12N2509/10
摘要： The present invention relates to an electric ovum denuding device and an ovum denuding method therefor. The electric ovum denuding device consists of an ovum denuding pipette, a control handle, a drive module, a control module, a display module, a power module, a memory, a tip, and/or a voice module, and/or a pressure sensor, and/or a control box, and/or a foot-operated switch controller, which form an integrated or a separable-component electric ovum denuding device. A stepper motor provides the power for blowing and sucking so as to denude the granulocytes at the outer periphery of an oocyte. The present invention provides an accurate, standardized, comfortable electric ovum denuding method and device, and avoids ovum denuding related risks, standardizes ovum denuding operation, and improves labor intensity.
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7.发明公开METHODS OF USING PIGMENT EPITHELIUM DERIVED FACTOR (PEDF) FOR THE TREATMENT AND PREVENTION OF AGENT-INDUCED GONADAL OR UTERINE TOXICITY 审中-公开法OFF色素上皮衍生因子（PEDF），用于治疗和预防活性诱导性腺或子宫毒性的使用
公开(公告)号：EP3125924A1
公开(公告)日：2017-02-08
申请号：EP15774029.1
申请日：2015-03-30
发明人： SHALGI, Ruth , CHUDERLAND, Dana , BAR-JOSEPH, Hadas , GOLDBERG, Keren , BEN-AHARON, Irit , STEMMER, Salomon M.
IPC分类号： A61K38/18 , A61P15/08 , A61K31/138
CPC分类号： A61K38/18 , A61K31/138 , A61K31/704 , C12N5/0609 , C12N2501/10 , G01N33/74 , G01N2333/475 , G01N2800/34 , G01N2800/36 , G01N2800/52 , G01N2800/709 , A61K2300/00
摘要： A method of treating or preventing gonadal or uterine toxicity induced by an agent in a subject is provided. Accordingly there is provided a method comprising administering to a subject a therapeutically effective amount of pigment epithelium-derived factor (PEDF), thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is, a method comprising determining gonadal function in a subject; and administering to the subject a therapeutically effective amount of PEDF, thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is a PEDF for use in the treatment or prevention of gonadal toxicity induced by an agent in a subject. Also provided are cell culture, a medium, a kit and method for improving oocyte quality ex-vivo.
摘要翻译： 提供治疗或预防由一种在对象中诱导剂性腺或子宫毒性的方法。 因此，提供包括给予受试者治疗有效量的色素上皮衍生因子（PEDF），从而治疗或预防由该试剂引起的性腺毒性的方法。 所以，提供的是，包括在主题确定采矿性腺功能的方法; 和给予所述受试者治疗有效量的PEDF，从而治疗或预防由药物引起的性腺毒性。 这样提供了用于通过在受试者中诱导剂性腺毒性的治疗或预防中使用的PEDF。 所以提供了细胞培养物，介质，试剂盒和用于提高卵母细胞质量体外方法。
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8.发明公开METHODS AND COMPOSITIONS FOR EX VIVO GENERATION OF DEVELOPMENTALLY COMPETENT EGGS FROM GERM LINE CELLS USING AUTOLOGOUS CELL SYSTEMS 审中-公开方法和组合物在体外生产发展能够使用自体细胞系统EGG种系细胞
公开(公告)号：EP3055408A1
公开(公告)日：2016-08-17
申请号：EP14852532.2
申请日：2014-10-07
CPC分类号： C12N5/0609 , A61K35/54 , C12N5/0682 , C12N2500/44 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/235 , C12N2502/04 , C12N2502/13 , C12N2506/02 , C12N2510/00
摘要： The present technology provides for methods for the directed differentiation of multi-potent cells, female germ line stem cells, or oogonial stem cells into oocytes, granulosa cells and/or granulosa precursor cells,
i.e ., "synthetic granulosa cells." The synthetic granulosa cells are useful in methods for growth and maturation of follicles or follicle-like structures and immature oocytes. Additionally, the synthetic granulosa cells are useful in methods of increasing ovarian derived hormones and growth factors in a subject in need thereof.-
9.发明公开METHODS AND COMPOSITIONS FOR GENERATION OF DEVELOPMENTALLY-INCOMPETENT EGGS IN RECIPIENTS OF NUCLEAR GENETIC TRANSFER 审中-公开方法和组合物的研制开发无法鸡蛋FOR细胞核遗传传输集装箱
公开(公告)号：EP3052110A1
公开(公告)日：2016-08-10
申请号：EP14850854.2
申请日：2014-10-02
IPC分类号： A61K35/54
CPC分类号： C12N5/0609 , A61K35/54 , C12N2501/998 , C12N2510/00 , C12N2517/10
摘要： The present technology provides for a developmentally-incompetent egg cell that is produce by genetically engineering (e.g., inactivating) at least one gene in an oocyte precursor cell and culturing the oocyte precursor cell in condition sufficient to produce an egg cell. The present technology also provides for methods of using the developmentally-incompetent egg cell.
摘要翻译： 本技术为一个发育-无能卵细胞确实是由至少在卵母细胞前体细胞基因工程改造（E. G。，失活）一种基因中并培养在足以产生卵细胞条件卵母细胞前体细胞中产生。 本技术从而提供使用发育-无能卵细胞的方法。
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10.发明公开
公开(公告)号：EP2987855A1
公开(公告)日：2016-02-24
申请号：EP15168666.4
申请日：2005-05-17
CPC分类号： C12N5/0611 , A61B17/43 , A61K35/14 , A61K35/28 , A61K2035/124 , C12N5/0609 , C12N5/0634 , C12N2506/11 , C12P21/06
摘要： The present invention relates to methods of isolation of female germline stem cells and their progenitors.
摘要翻译： 本发明涉及分离雌性生殖系干细胞及其祖细胞的方法。
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