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公开(公告)号:EP3292219A1
公开(公告)日:2018-03-14
申请号:EP16789403.9
申请日:2016-04-14
申请人: Ramot at Tel-Aviv University Ltd. , Tsinghua University , Institute Of Microbiology Chinese Academy Of Sciences
发明人: ZHU, Ting , EBENSTEIN, Yuval , LOU, Chunbo , JIANG, Wenjun , ZHAO, Xuejin , GABRIELI, Tslil
IPC分类号: C12Q1/68
CPC分类号: C12N15/1003 , C12N15/101 , C12Q1/6806 , C12Q1/6869 , C12Q2521/301
摘要: A method of DNA fragmentation is provided. The method comprising incubating a semi-solid biological sample which comprises the DNA with an auxiliary domain-directed nuclease having a binding affinity and selectivity to pre-defined sites in the DNA so as to yield a DNA fragment-of-interest, to thereby fragment the DNA.