PROCESS FOR THE PRODUCTION OF POLYMORPH FORM I OF AGOMELATINE
    2.
    发明公开
    PROCESS FOR THE PRODUCTION OF POLYMORPH FORM I OF AGOMELATINE 有权
    用于生产阿戈美拉汀的多晶型我

    公开(公告)号:EP2558440A1

    公开(公告)日:2013-02-20

    申请号:EP11714311.5

    申请日:2011-04-14

    申请人: Ratiopharm GmbH

    CPC分类号: C07C233/18 C07C231/24

    摘要: The invention provides a process for the preparation of the polymorph from I of agomelatine, characterized by the following crystal data: C
    15 H
    17 N0
    2 Mr = 243.30 Orthorhombic Pca2
    1 a = 31.501 (4) Å b = 9.5280 (10) Å c = 17.906 (2) Å Z = 16 the process comprising the process steps of: a) dissolving agomelatine in a solvent to obtain a solution, b) adding the solution to an organic anti-solvent having a temperature of 30°C or below, whereby crystals of the polymorph form I of agomelatine are formed, wherein the solvent of step a) is miscible with the anti-solvent of step b), c) isolating the crystals of the polymorph form I of agomelatine and d) optionally drying the isolated crystals of the polymorph form I of agomelatine.