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公开(公告)号：EP4273172A2
公开(公告)日：2023-11-08
申请号：EP23182446.7
申请日：2017-09-22
发明人： HABER, Lauric , SMITH, Eric , KELLY, Marcus , KIRSHNER, Jessica , COETZEE, Sandra , CRAWFORD, Alison , NITTOLI, Thomas , LIU, Yashu
IPC分类号： C07K16/46
摘要： Mucin 16 (MUC16) is highly expressed in ovarian cancer and expression on cancer cells is shown to protect tumor cells from the immune system. The present invention provides novel full-length human IgG antibodies that bind to human andMUC16 (monospecific antibodies). The present invention also provides novel bispecific antibodies (bsAbs) that bind to both MUC16 and CD3 and activate T cells via the CD3 complex in the presence of MUC16-expressing tumors. According to certain embodiments, the present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human and monkey CD3, and a second antigen-binding molecule that specifically binds human and monkey MUC16. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing MUC16. The bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced MUC16-targeted immune response is desired and/or therapeutically beneficial. For example, the bispecific antibodies of the invention are useful for the treatment of various cancers, including ovarian cancer. The present invention also includes anti-MUC16 antibody drug conjugates which inhibit tumor growth in vivo. In some embodiments, the anti-MUC16 antibodies are useful in diagnostic methods for identifying the presence of MUC16 in tissue and/or plasma samples.
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公开(公告)号：EP3273998A1
公开(公告)日：2018-01-31
申请号：EP16714199.3
申请日：2016-03-25
发明人： NITTOLI, Thomas , MARKOTAN, Thomas
CPC分类号： C07D498/18 , A61K47/6803 , A61K47/6849 , A61K47/6889
摘要： Provided herein are maytansinoid derivatives, conjugates thereof, and methods of treating or preventing proliferative diseases with the same.
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3.发明公开
公开(公告)号：EP3148592A2
公开(公告)日：2017-04-05
申请号：EP15738502.2
申请日：2015-06-01
发明人： NITTOLI, Thomas , KUNZ, Arthur
CPC分类号： C07K16/2866 , A61K47/6801 , A61K47/6803 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6889 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K16/30 , C07K2317/34 , C07K2317/77 , C07K2317/92
摘要： The present disclosure relates to conjugates comprising biologically active molecules linked to a multimeric antigen-binding compound or a multimeric immunoglobulin via a linker. The disclosure further provides reagents and methods of manufacturing the conjugates and the linkers. The disclosure also provides compositions comprising the conjugates, methods of modifying abnormal cell growth and methods of treatment using the conjugates or the compositions.
摘要翻译： 本发明涉及缀合物，其包括连接到多聚体的抗原结合化合物或经由左侧的多聚免疫球蛋白的生物活性分子。 本发明还提供试剂和制造该偶联物和接头的方法。 所以本发明提供了包含偶联物，修改异常细胞生长，并使用缀合物或组合物的治疗方法的方法。
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4.发明公开
公开(公告)号：EP2968593A1
公开(公告)日：2016-01-20
申请号：EP14729755.0
申请日：2014-03-14
发明人： NITTOLI, Thomas
CPC分类号： A61K47/48384 , A61K31/5365 , A61K47/6803 , A61K47/6849 , A61K47/6855 , A61K47/6869 , A61K47/6871 , C07D507/00
摘要： The present disclosure relates to linker compounds that are useful in covalently linking biologically active molecules with Ligands. The disclosed compounds also relate to biologically active molecules and Ligand conjugates, wherein the biologically active molecule is linked to the Ligand through a linker. The disclosure further provides compositions comprising biologically active molecule-ligand conjugates, methods of modifying abnormal cell growth and methods of treatment using the conjugates or the compositions.
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公开(公告)号：EP4273172A3
公开(公告)日：2024-02-28
申请号：EP23182446.7
申请日：2017-09-22
发明人： HABER, Lauric , SMITH, Eric , KELLY, Marcus , KIRSHNER, Jessica , COETZEE, Sandra , CRAWFORD, Alison , NITTOLI, Thomas , LIU, Yashu
IPC分类号： C07K16/30 , A61K39/395 , C07K16/44 , C07K16/28 , C07K16/46
摘要： Mucin 16 (MUC16) is highly expressed in ovarian cancer and expression on cancer cells is shown to protect tumor cells from the immune system. The present invention provides novel full-length human IgG antibodies that bind to human andMUC16 (monospecific antibodies). The present invention also provides novel bispecific antibodies (bsAbs) that bind to both MUC16 and CD3 and activate T cells via the CD3 complex in the presence of MUC16-expressing tumors. According to certain embodiments, the present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human and monkey CD3, and a second antigen-binding molecule that specifically binds human and monkey MUC16. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing MUC16. The bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced MUC16-targeted immune response is desired and/or therapeutically beneficial. For example, the bispecific antibodies of the invention are useful for the treatment of various cancers, including ovarian cancer. The present invention also includes anti-MUC16 antibody drug conjugates which inhibit tumor growth in vivo. In some embodiments, the anti-MUC16 antibodies are useful in diagnostic methods for identifying the presence of MUC16 in tissue and/or plasma samples.
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公开(公告)号：EP4031187A1
公开(公告)日：2022-07-27
申请号：EP20786642.7
申请日：2020-09-19
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公开(公告)号：EP3897841A1
公开(公告)日：2021-10-27
申请号：EP19842960.7
申请日：2019-12-20
IPC分类号： A61P31/06 , C07D498/18 , C07K16/12
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公开(公告)号：EP3273998B1
公开(公告)日：2019-09-04
申请号：EP16714199.3
申请日：2016-03-25
发明人： NITTOLI, Thomas , MARKOTAN, Thomas
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公开(公告)号：EP3408271A1
公开(公告)日：2018-12-05
申请号：EP17704134.0
申请日：2017-01-24
IPC分类号： C07D498/18 , A61K31/535 , A61P35/00
CPC分类号： A61K47/6851 , A61K47/68 , C07D498/18 , C07K16/32 , C07K16/40
摘要： Provided herein are maytansinoid compounds, derivatives thereof, conjugates thereof, and methods of treating or preventing proliferative diseases with the same.
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公开(公告)号：EP4232481A1
公开(公告)日：2023-08-30
申请号：EP21815730.3
申请日：2021-10-21
发明人： DALY, Christopher , DELFINO, Frank , HAN, Amy , NITTOLI, Thomas , ZHANG, Li
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