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公开(公告)号：EP3412676A1
公开(公告)日：2018-12-12
申请号：EP18183968.9
申请日：2011-08-08
发明人： HIRST, Gavin , REDDY, Raja , HECKER, Scott , TOTROV, Maxim , GRIFFITH, David, C. , RODNY, Olga , DUDLEY, Michael, N. , BOYER, Serge
摘要： Disclosed herein are are methods for the preparation of cyclic boronic acid ester derivatives.
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2.发明公开
公开(公告)号：EP3140310A1
公开(公告)日：2017-03-15
申请号：EP15788682.1
申请日：2015-04-30
发明人： HECKER, Scott , BOYER, Serge
摘要： Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.
摘要翻译： 本文公开了合成抗微生物化合物的硼酸酯中间体及其用途和制备。 一些实施方案涉及结晶硼酸盐衍生物及其在合成治疗化合物中的用途。
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公开(公告)号：EP2941246A1
公开(公告)日：2015-11-11
申请号：EP14735173.8
申请日：2014-01-02
发明人： REDDY, Raja , GLINKA, Tomasz , TOTROV, Maxim , HECKER, Scott
CPC分类号： A61K31/69 , A61K31/407 , A61K31/4196 , A61K31/427 , A61K31/546 , A61K45/06 , C07F5/025 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , A61K2300/00
摘要： Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents. Other embodiments relate to pharmaceutical compositions containing boronic acid derivatives and additional excipient such as meglumine.
摘要翻译： 本文公开了抗微生物化合物组合物，药物组合物，其用途和制备。 一些实施方案涉及硼酸衍生物及其作为治疗剂的用途。 其他实施方案涉及含有硼酸衍生物和另外的赋形剂例如葡甲胺的药物组合物。
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公开(公告)号：EP2603514B1
公开(公告)日：2018-07-18
申请号：EP11816882.2
申请日：2011-08-08
发明人： HIRST, Gavin , REDDY, Raja , HECKER, Scott , TOTROV, Maxim , GRIFFITH, David, C. , RODNY, Olga , DUDLEY, Michael, N. , BOYER, Serge
CPC分类号： A61K31/69 , A61K9/0019 , A61K9/0053 , A61K31/407 , A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/546 , A61K45/06 , C07F5/025 , Y02A50/401 , Y02A50/406 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/483 , A61K2300/00
摘要： Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
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5.发明公开BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF 审中-公开BORSÄUREDERIVATEUNDEREREUTISCHE VERWENDUNGEN DAVON
公开(公告)号：EP3145936A1
公开(公告)日：2017-03-29
申请号：EP15796968.4
申请日：2015-05-18
发明人： REDDY, Raja , GLINKA, Tomasz , HECKER, Scott , TOTROV, Maxim , RODNY, Olga
摘要： Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.
摘要翻译： 本文公开的是抗微生物化合物组合物，药物组合物，其用途和制备。 一些实施方案涉及硼酸衍生物及其作为治疗剂的用途。
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6.发明授权BORON CONTAINING POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTICS USES THEREOF 有权含硼多元抑制剂用于BAKTERIENEFFLUXPUMPEN及其治疗用途
公开(公告)号：EP2673281B1
公开(公告)日：2016-04-13
申请号：EP12745348.8
申请日：2012-02-06
发明人： GLINKA, Tomasz , HIGUCHI, Robert , HECKER, Scott , EASTMAN, Brian , RODNY, Olga
CPC分类号： C07K5/06191 , A61K38/05 , C07F5/025
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7.发明公开BORON CONTAINING POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTICS USES THEREOF 有权含硼多元抑制剂用于BAKTERIENEFFLUXPUMPEN及其治疗用途
公开(公告)号：EP2673281A1
公开(公告)日：2013-12-18
申请号：EP12745348.8
申请日：2012-02-06
发明人： GLINKA, Tomasz , HIGUCHI, Robert , HECKER, Scott , EASTMAN, Brian , RODNY, Olga
CPC分类号： C07K5/06191 , A61K38/05 , C07F5/025
摘要： Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.
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8.发明授权
公开(公告)号：EP3412676B1
公开(公告)日：2020-02-12
申请号：EP18183968.9
申请日：2011-08-08
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公开(公告)号：EP3140310B1
公开(公告)日：2019-08-07
申请号：EP15788682.1
申请日：2015-04-30
发明人： HECKER, Scott , BOYER, Serge
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公开(公告)号：EP3164406A1
公开(公告)日：2017-05-10
申请号：EP15815718.0
申请日：2015-06-29
发明人： REDDY, Raja K. , GLINKA, Tomasz , TOTROV, Maxim , HECKER, Scott , RODNY, Olga
CPC分类号： A61K31/69 , A61K31/407 , A61K31/427 , A61K45/06 , C07F5/025 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , A61K2300/00
摘要： Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.
摘要翻译： 本文公开了抗微生物化合物组合物，药物组合物，其用途和制备。 一些实施方案涉及硼酸衍生物及其作为治疗剂的用途。
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