公开(公告)号：EP1954132A2

公开(公告)日：2008-08-13

申请号：EP07751654.0

申请日：2007-02-22

申请人： Renovis, Inc.

发明人： KELLY, Michael, G. ,  KAUB, Carl, J. ,  KINCAID, John ,  JANAGANI, Satyanarayana ,  WU, Guoxian ,  WEI, Zhi-Liang ,  SAHASRABUDHE, Kiran ,  DUNCTON, Matthew ,  UPASANI, Ravindra, B. ,  FANG, Yunfeng ,  COX, Matthew

IPC分类号： A01N37/18 ,  A61K31/16

CPC分类号： C07D209/08 ,  C07D209/48 ,  C07D209/50 ,  C07D215/06 ,  C07D215/38 ,  C07D217/02 ,  C07D217/22 ,  C07D231/56 ,  C07D235/06 ,  C07D235/08 ,  C07D237/28 ,  C07D241/42 ,  C07D263/58 ,  C07D265/16 ,  C07D265/36 ,  C07D267/14 ,  C07D277/46 ,  C07D277/64 ,  C07D295/088 ,  C07D295/13 ,  C07D317/52 ,  C07D317/58 ,  C07D319/18 ,  C07D333/54 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  C07D491/052 ,  C07D498/04

摘要： Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

公开(公告)号：EP1677745A2

公开(公告)日：2006-07-12

申请号：EP04794970.6

申请日：2004-10-14

申请人： Renovis, Inc.

发明人： KELLY, Michael, G. ,  UPASANI, Ravindra, B. ,  JANAGANI, Satyanarayana

IPC分类号： A61K8/18

CPC分类号： C07D213/64 ,  C07C291/02 ,  C07C323/47 ,  C07D217/24

摘要： Disclosed are aryl, heteroaromatic and bicyclic aryl nitrone compounds and pharmaceutical compositions containing such derivatives. The disclosed compositions are useful for preventing and/or treating pain, neurodegenerative, autoimmune and inflammatory diseases or conditions in mammals.

公开(公告)号：EP1660011A2

公开(公告)日：2006-05-31

申请号：EP04780091.7

申请日：2004-08-04

申请人： Renovis, Inc.

发明人： KELLY, Michael, G. ,  JANAGANI, Satyanarayana ,  UPASANI, Ravindra, B.

IPC分类号： A61K6/00

CPC分类号： C07C291/02 ,  C07C309/46 ,  C07C309/61 ,  C07C309/76 ,  C07C311/16 ,  C07C323/47 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D209/42 ,  C07D213/65 ,  C07D213/70 ,  C07D213/74 ,  C07D213/75 ,  C07D215/36 ,  C07D231/12 ,  C07D233/06 ,  C07D295/135 ,  C07D333/38 ,  C07F9/3856 ,  C07F9/4021

摘要： Disclosed are aryl, heteroaromatic and bicyclic aryl nitrone compounds and pharmaceutical compositions containing such derivatives. The disclosed compositions are useful for preventing and/or treating pain, neurodegenerative, autoimmune and inflammatory diseases or conditions in mammals.

摘要翻译： 公开的是芳基，杂芳族和双环芳基硝酮化合物和含有寻求衍生物的药物组合物。 盘游离缺失的组合物是用于预防和/或治疗疼痛，神经变性，自身免疫和炎性疾病或病症在哺乳动物中是有用的。

公开(公告)号：EP1853269A2

公开(公告)日：2007-11-14

申请号：EP06736043.8

申请日：2006-02-24

申请人： Renovis, Inc.

发明人： KELLY, Michael ,  KINCAID, John ,  DUNCTON, Matthew ,  SAHASRABUDHE, Kiran ,  JANAGANI, Satyanarayana ,  UPASANI, Ravindra, B. ,  WU, Guoxian ,  FANG, Yunfeng ,  WEI, Zhi-liang ,  KAUB, Carl

IPC分类号： A61K31/538 ,  A61K31/4709 ,  C07D405/14 ,  C07D413/02

CPC分类号： C07D209/08 ,  C07D209/48 ,  C07D209/50 ,  C07D215/06 ,  C07D215/38 ,  C07D217/02 ,  C07D217/22 ,  C07D231/56 ,  C07D235/06 ,  C07D235/08 ,  C07D237/28 ,  C07D241/42 ,  C07D263/58 ,  C07D265/16 ,  C07D265/36 ,  C07D267/14 ,  C07D277/46 ,  C07D277/64 ,  C07D295/088 ,  C07D295/13 ,  C07D317/52 ,  C07D317/58 ,  C07D319/18 ,  C07D333/54 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  C07D491/052 ,  C07D498/04

摘要： Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

公开(公告)号：EP1680109A1

公开(公告)日：2006-07-19

申请号：EP04794499.6

申请日：2004-10-07

申请人： Renovis, Inc.

发明人： UPASANI, Ravindra, B. ,  KELLY, Michael, G. ,  JANAGANI, Satyanarayana

IPC分类号： A61K31/44 ,  A61K31/165 ,  C07C233/30 ,  C07D213/02

CPC分类号： C07D319/18 ,  C04B35/632 ,  C07C233/65 ,  C07C233/66 ,  C07C233/69 ,  C07C233/73 ,  C07C233/75 ,  C07C255/60 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07D207/337 ,  C07D209/08 ,  C07D209/14 ,  C07D209/16 ,  C07D209/18 ,  C07D209/88 ,  C07D211/34 ,  C07D211/58 ,  C07D213/40 ,  C07D213/53 ,  C07D213/56 ,  C07D213/70 ,  C07D213/75 ,  C07D213/82 ,  C07D215/12 ,  C07D215/38 ,  C07D217/02 ,  C07D221/10 ,  C07D221/12 ,  C07D221/14 ,  C07D231/40 ,  C07D233/54 ,  C07D233/61 ,  C07D233/64 ,  C07D239/42 ,  C07D277/46 ,  C07D295/13 ,  C07D295/135 ,  C07D307/14 ,  C07D307/52 ,  C07D307/54 ,  C07D317/50 ,  C07D317/58 ,  C07D319/12 ,  C07D333/20 ,  C07D333/24 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06

摘要： Compounds are disclosed that have a formula represented by the following: Formula (I) The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

摘要翻译： 公开了具有下列化学式的化合物：化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例的疼痛 ，炎症，创伤性损伤等。

公开(公告)号：EP1578717A2

公开(公告)日：2005-09-28

申请号：EP03773284.9

申请日：2003-10-15

申请人： Renovis, Inc.

发明人： KHAN, M., Amin ,  UPASANI, Ravindra, B. ,  WOOD, Paul, L.

IPC分类号： C07C207/00 ,  A61K31/04

CPC分类号： C07C309/46 ,  C07C291/02 ,  C07C309/73 ,  C07C311/21 ,  C07C311/51 ,  C07C2601/14 ,  C07D309/12

摘要： Disclosed are nitrone compounds and pharmaceutical compositions containing such compounds. The nitrone compounds have one to six additional carbons bridging between the nitrone functionality and the nitrone aryl ring. The disclosed compositions are useful as therapeutics for inflammation-related conditions and analgesia in mammals, such as arthritis, and for neuropathic pain and traumatic injuries such as traumatic brain injury and acute spinal cord injury. The invention accordingly extends to the use of the compounds and compositions for the stated treatments, and as appropriate, to the use of the compounds for the preparation of pharmaceutical compositions for such treatments.

摘要翻译： 本发明公开了硝酮化合物和含受试化合物的药物组合物。 硝酮化合物对硝酮功能和硝酮芳基环之间一至六个碳额外桥接。 该游离缺失盘组合物可作为治疗炎症相关的条件和镇痛的哺乳动物，颜色有用的：如关节炎和神经性疼痛和外伤：如脑外伤和急性脊髓损伤。