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公开(公告)号：EP1817291A1
公开(公告)日：2007-08-15
申请号：EP05851351.6
申请日：2005-11-03
发明人： WENTLAND, Mark P.
IPC分类号： C07D221/26 , A61K31/485
CPC分类号： C07D221/28 , C07D215/14 , C07D215/20 , C07D221/26 , C07D489/00 , C07D489/02 , C07D489/08
摘要： 4-Hydroxybenzomorphans containing carboxamide or thiocarboxamide at the 3-position are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
摘要翻译： 在3-位含有羧酰胺或硫代甲酰胺的4-羟基苯并吗喃可用作止痛剂，止泻剂，抗惊厥剂，镇咳药和抗成瘾药物。
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2.发明授权MORPHINANE DERIVATIVES CONTAINING A CARBOXAMIDE GROUP AS OPIOID RECEPTOR LIGANDS 有权含有羧酰胺基团的吗啡烷衍生物作为阿片受体配体
公开(公告)号：EP2550253B9
公开(公告)日：2016-09-21
申请号：EP11715100.1
申请日：2011-03-22
发明人： WENTLAND, Mark P.
IPC分类号： C07D221/28 , C07D489/08 , A61K45/06 , A61K31/4748 , A61K31/485 , C07D221/22 , C07D405/12
CPC分类号： C07D489/00 , A61K31/439 , A61K31/4748 , A61K31/485 , A61K45/06 , C07D221/22 , C07D221/26 , C07D221/28 , C07D405/12 , C07D489/08
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3.发明授权MORPHINANE DERIVATIVES CONTAINING A CARBOXAMIDE GROUP AS OPIOID RECEPTOR LIGANDS 有权CARBOXAMID-BIOISOSTERE VON OPIATEN
公开(公告)号：EP2550253B1
公开(公告)日：2016-04-27
申请号：EP11715100.1
申请日：2011-03-22
发明人： WENTLAND, Mark P.
IPC分类号： C07D221/28 , C07D489/08 , A61K45/06 , A61K31/4748 , A61K31/485 , C07D221/22 , C07D405/12
CPC分类号： C07D489/00 , A61K31/439 , A61K31/4748 , A61K31/485 , A61K45/06 , C07D221/22 , C07D221/26 , C07D221/28 , C07D405/12 , C07D489/08
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公开(公告)号：EP2318372A1
公开(公告)日：2011-05-11
申请号：EP09790652.3
申请日：2009-07-21
发明人： WENTLAND, Mark P.
IPC分类号： C07D221/26 , A61K31/485 , A61P25/36 , A61P29/00
CPC分类号： C07D221/26
摘要： 8-Substituted-2,6-methano-3-benzazocines of general structure (I) are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
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公开(公告)号：EP2148864A2
公开(公告)日：2010-02-03
申请号：EP08755544.7
申请日：2008-05-15
发明人： WENTLAND, Mark P.
IPC分类号： C07D221/26 , C07D221/28 , C07D489/09 , C07D489/12 , A61K31/485 , A61P25/04
CPC分类号： C07D221/26 , C07D221/28 , C07D489/09 , C07D489/12
摘要： Compounds of formula (I) are disclosed. In these compounds (1) or (2) is a heterocyclic ring. The compounds are useful as analgesics, anti-pruritics, anti-diarrheal agents, anticonvulsants, antitussives, anorexics/antiobesity agents and as treatments for hyperalgesia, drug addiction, respiratory depression, dyskinesia, pain (including neuropathic pain), irritable bowel syndrome and gastrointestinal motility disorders.
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公开(公告)号：EP2318372B9
公开(公告)日：2015-05-06
申请号：EP09790652.3
申请日：2009-07-21
发明人： WENTLAND, Mark P.
IPC分类号： C07D221/26 , A61K31/485 , A61P25/36 , A61P29/00
CPC分类号： C07D221/26
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公开(公告)号：EP2318372B1
公开(公告)日：2015-01-14
申请号：EP09790652.3
申请日：2009-07-21
发明人： WENTLAND, Mark P.
IPC分类号： C07D221/26 , A61K31/485 , A61P25/36 , A61P29/00
CPC分类号： C07D221/26
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公开(公告)号：EP2550253A2
公开(公告)日：2013-01-30
申请号：EP11715100.1
申请日：2011-03-22
发明人： WENTLAND, Mark P.
IPC分类号： C07D221/28
CPC分类号： C07D489/00 , A61K31/439 , A61K31/4748 , A61K31/485 , A61K45/06 , C07D221/22 , C07D221/26 , C07D221/28 , C07D405/12 , C07D489/08
摘要： A compound of formula I is disclosed. Compounds of formula I are useful as analgesics, anti-inflammatory agents, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
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