公开(公告)号：EP2900685B1

公开(公告)日：2017-10-25

申请号：EP13773563.5

申请日：2013-09-26

申请人： Research Development Foundation

发明人： BROWN, Dennis, T. ,  HERNANDEZ, Raquel

IPC分类号： C07K14/18 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K38/00 ,  C07K7/00 ,  C12N2770/36122 ,  C12N2770/36134

公开(公告)号：EP2900685A1

公开(公告)日：2015-08-05

申请号：EP13773563.5

申请日：2013-09-26

申请人： Research Development Foundation

发明人： BROWN, Dennis, T. ,  HERNANDEZ, Raquel

IPC分类号： C07K14/005 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K38/00 ,  C07K7/00 ,  C12N2770/36122 ,  C12N2770/36134

摘要： Novel attenuating deletions of Chikungunya virus E2 polypeptides are provided as are attenuated viruses comprising the deletions. Also provided are immunogenic compositions comprising the attenuated viruses and methods of producing such viruses in cells (such as insect cells). Viruses of the embodiments can be used for immunization of animals to provide protection from the pathogenic effects of Chikungunya virus infection.

摘要翻译： 提供基孔肯雅病毒E2多肽的新型减毒缺失是包含缺失的减毒病毒。 还提供了包含减毒病毒的免疫原性组合物和在细胞（如昆虫细胞）中产生这种病毒的方法。 实施方案的病毒可用于免疫动物以提供对基孔肯雅病毒感染的致病作用的保护。

公开(公告)号：EP2550292B1

公开(公告)日：2017-11-22

申请号：EP11760135.1

申请日：2011-03-23

申请人： Research Development Foundation ,  Arbovax Inc.

发明人： BROWN, Dennis, T. ,  HERNANDEZ, Raquel ,  THOMAS, Malcolm, E. ,  SMITH, Katherine, M. ,  NANDA, Kavita

IPC分类号： C07K14/18 ,  C12N15/40 ,  C12N7/01 ,  A61K39/12 ,  A61P31/14

CPC分类号： C12N7/00 ,  A61K39/12 ,  C12N2770/24134 ,  C12N2770/24161 ,  C12N2770/24162 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394 ,  Y02A50/396

摘要： Methods and compositions concerning mutant flaviviruses with host range mutations. In some embodiments the invention concerns nucleotide sequences that encode mutant flavivirus proteins. Viruses comprising these sequences that display reduced replication in mammalian cells are provided. In further aspects of the invention, flavivirus vaccine compositions are provided. In another embodiment the invention provides methods for vaccination against flavivirus infection.

公开(公告)号：EP2550292A2

公开(公告)日：2013-01-30

申请号：EP11760135.1

申请日：2011-03-23

申请人： Research Development Foundation ,  Arbovax Inc.

发明人： BROWN, Dennis, T. ,  HERNANDEZ, Raquel ,  THOMAS, Malcolm, E. ,  SMITH, Katherine, M. ,  NANDA, Kavita

IPC分类号： C07K14/18 ,  C12N15/40 ,  C12N7/01 ,  A61K39/12 ,  A61P31/14

CPC分类号： C12N7/00 ,  A61K39/12 ,  C12N2770/24134 ,  C12N2770/24161 ,  C12N2770/24162 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394 ,  Y02A50/396

摘要： Methods and compositions concerning mutant flaviviruses with host range mutations. In some embodiments the invention concerns nucleotide sequences that encode mutant flavivirus proteins. Viruses comprising these sequences that display reduced replication in mammalian cells are provided. In further aspects of the invention, flavivirus vaccine compositions are provided. In another embodiment the invention provides methods for vaccination against flavivirus infection.