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公开(公告)号：EP3565589A1
公开(公告)日：2019-11-13
申请号：EP18701943.5
申请日：2018-01-03
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公开(公告)号：EP4178359A2
公开(公告)日：2023-05-17
申请号：EP21837938.6
申请日：2021-07-06
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公开(公告)号：EP3113630B1
公开(公告)日：2019-12-11
申请号：EP15710693.1
申请日：2015-03-05
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4.发明公开
公开(公告)号：EP4237445A2
公开(公告)日：2023-09-06
申请号：EP21887747.0
申请日：2021-11-01
IPC分类号： C07K16/12 , G01N33/68 , A61K39/395 , A61L27/54 , A61K39/40
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公开(公告)号：EP3365027A2
公开(公告)日：2018-08-29
申请号：EP16856372.4
申请日：2016-10-14
IPC分类号： A61K49/00 , A61K39/02 , A61K39/108
CPC分类号： A61K38/16 , A61K8/64 , A61K9/1652 , A61K39/0216 , A61K45/06 , A61K47/36 , A61K47/6921 , A61K2300/00 , A61P31/04 , A61Q17/005 , Y02A50/401
摘要： Methods of and compositions for breaking down a biofilm or inhibiting, preventing or treating a microbial infection that produces a biofilm are disclosed, which involves administration of an interfering agent capable of specifically competing, titrating, or inhibiting the binding of an HU protein to a microbial DNA. By competing with HU proteins that bind to DNA scaffold in the biofilm, these interfering agents destabilize the biofilm leading to destruction and removal of the biofilm by the immune system. Further method and composition aspects are contemplated in relation to infections caused by bacteria that export an HU protein.
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公开(公告)号：EP3328429A1
公开(公告)日：2018-06-06
申请号：EP16833687.3
申请日：2016-08-01
IPC分类号： A61K39/40 , A61K39/395 , C07K16/12 , C07K16/18 , C12N15/62
CPC分类号： A61K39/395 , A61K8/64 , A61K39/40 , A61K2039/507 , A61L27/54 , A61L29/16 , A61L2300/404 , A61Q11/00 , A61Q17/005 , C07K16/12 , C07K16/1217 , C07K16/1232 , C07K16/1242 , C07K16/1271 , C07K16/1275 , C07K16/18 , C07K2317/34 , C12N15/62
摘要： This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that are released from the biofilm by our technology are more readily cleared by the remainder of the host's immune system.
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7.发明公开PROBIOTIC FORMULATIONS AND METHODS FOR USE 审中-公开PROBIOTISCHE FORMULIERUNGEN UND VERFAHREN ZUR VERWENDUNG
公开(公告)号：EP3113630A2
公开(公告)日：2017-01-11
申请号：EP15710693.1
申请日：2015-03-05
摘要： Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
摘要翻译： 本文提供了包含生物相容性微球，生物膜产生益生菌，益生元和/或前体膜的组合物。 还提供了使用该组合物制备和配制用于治疗或预防疾病的组合物和方法的方法。
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公开(公告)号：EP2964257A1
公开(公告)日：2016-01-13
申请号：EP14759477.4
申请日：2014-03-10
发明人： BAKALETZ, Lauren O.
IPC分类号： A61K39/395 , A61K39/145 , A61K39/00
CPC分类号： A61K39/102 , A61K9/0014 , A61K9/7084 , A61K39/385 , A61K2039/54 , A61K2039/541 , A61K2039/545 , A61K2039/55544 , A61K2039/60 , A61K2039/6068
摘要： Provided are topical delivery systems and methods for treating and/or preventing a disease or disorder in a subject, or for eliciting an immune response in a subject, including applying, to at least a portion of the subject's post-auricular region, a topical delivery system including a therapeutically effective amount of a topical pharmaceutical composition comprising at least one active agent and a pharmaceutically acceptable carrier and/or adjuvant. The topical pharmaceutical composition can include a topical immunogenic composition. The topical delivery system can further include a flexible substrate in communication with the topical immunogenic composition. The subject can be a pediatric subject.
摘要翻译： 提供用于治疗和/或预防受试者的疾病或病症或用于在受试者中引起免疫应答的局部递送系统和方法，包括向受试者的耳后区的至少一部分施用局部递送 系统，其包括治疗有效量的包含至少一种活性剂和药学上可接受的载体和/或佐剂的局部药物组合物。 局部药物组合物可以包含局部免疫原性组合物。 局部递送系统可以进一步包括与局部免疫原性组合物连通的柔性基底。 受试者可以是儿科患者。
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公开(公告)号：EP4361171A3
公开(公告)日：2024-07-31
申请号：EP24160295.2
申请日：2020-07-07
IPC分类号： C07K16/12 , C07K14/195 , A61P31/04 , A61K39/00 , C07K16/10
CPC分类号： C07K16/12 , C07K16/1018 , C07K2317/7620130101 , A61K2039/50520130101 , A61P31/04 , C07K2317/5520130101 , C07K2317/2420130101 , C07K2317/56520130101 , C07K2317/5620130101
摘要： Provided herein are methods and compositions for disrupting biofilms in vitro and in vivo. Also disclosed are antibodies comprising a specified heavy chain (HC) immunoglobulin variable domain sequence and/or a specified light chain (LC) immunoglobulin variable domain sequence.
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公开(公告)号：EP3997120A2
公开(公告)日：2022-05-18
申请号：EP20836444.8
申请日：2020-07-07
IPC分类号： C07K16/12 , C07K14/195
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