公开(公告)号：EP0993301A1

公开(公告)日：2000-04-19

申请号：EP97940580.0

申请日：1997-08-22

申请人： RESEARCH TRIANGLE INSTITUTE

发明人： KUHAR, Michael, J. ,  CARROLL, Frank, I. ,  BOJA, John, W. ,  LEWIN, Anita, H. ,  ABRAHAM, Philip

IPC分类号： A61K31/46 ,  C07D451/02 ,  A61P25/30 ,  A61P25/16

CPC分类号： C07D451/02 ,  C07F7/2212

摘要： The invention relates to novel compounds which show high affinity for cocaine receptors in the brain, particularly dopamine and serotonin transporter sites. The compounds may be used as imaging or pharmaceutical agents, in the diagnosis and treatment of drug addiction, depression, anorexia and neurodegenerative diseases.

公开(公告)号：EP1023289A1

公开(公告)日：2000-08-02

申请号：EP98953182.7

申请日：1998-10-07

申请人： RESEARCH TRIANGLE INSTITUTE

发明人： KUHAR, Michael, J. ,  CARROLL, Frank, I. ,  BOJA, John, W. ,  LEWIN, Anita, H. ,  ABRAHAM, Philip

IPC分类号： C07D451/02 ,  A61K51/00

CPC分类号： A61K51/0448 ,  C07D451/02

摘要： The 3α isomer of RTI-55, RTI-352, is an effective in vivo binding ligand that reflects greater selectivity for the dopamine transporter than is observed with RTI-55. In addition, there is also a more rapid achievement of apparent equilibrium in the striatal-to-cerebellar ratio (compared to RTI-55) as the ratio peaks at about 30 min and is maintained for about 20 min thereafter. Such apparent equilibrium is useful in developing an approach to measuring the number of dopamine transporters present in tissues. Moreover, these results indicate that the utilization of 3α isomers of a variety of 3β (substituted phenyl) tropanes will result in greater selectivity for dopamine transporters and a more rapid of achievement of apparent equilibrium.

公开(公告)号：EP0713484A1

公开(公告)日：1996-05-29

申请号：EP94925860.0

申请日：1994-08-11

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  RESEARCH TRIANGLE INSTITUTE

发明人： ROTHMAN, Richard ,  CARROLL, Frank, I. ,  BLOUGH, Bruce ,  MASCARELLA, Samuel, W.

IPC分类号： C07D487 ,  A61K31 ,  A61P25 ,  A61P43 ,  C07D209 ,  C07D451 ,  C07D471

CPC分类号： C07D471/08 ,  C07D209/70 ,  C07D451/00

摘要： The present invention provides a compound having structure (I), (II) or (III). The present invention also provides a pharmaceutical composition comprising the compound above and a pharmaceutically acceptable carrier. The present invention further provides a method for treating a disease characterized by a dopamine deficiency which comprises administering to a subject in need of such treatment an amount of the pharmaceutical composition above effective to treat the disease.

公开(公告)号：EP2773352A2

公开(公告)日：2014-09-10

申请号：EP12856118.0

申请日：2012-12-10

申请人： Research Triangle Institute, International

发明人： CARROLL, Frank, I. ,  THOMAS, James, B. ,  NAVARRO, Hernan, A. ,  MASCARELLA, S., Wayne ,  RUNYON, Scott, P. ,  JIN, Chunyang ,  KORMOS, Chad, M.

IPC分类号： A61K31/496

CPC分类号： C07D401/12 ,  C07D241/04 ,  C07D295/13

摘要： Provided are compounds represented by the formula: where R, Y
3 , R
1 ,
R
2 , R
3 , R
4 , R
6 , G, R
7 , E
1 , E
2 , A, B, W, X, Y and Z are as defined herein.

摘要翻译： 提供了由下式表示的化合物：其中R，Y3，R1，R2，R3，R4，R6，G，R7，E1，E2，A，B，W，X，Y和Z如本文所定义。

公开(公告)号：EP1303274A1

公开(公告)日：2003-04-23

申请号：EP01937168.1

申请日：2001-05-22

申请人： Research Triangle Institute

发明人： CARROLL, Frank, I.

IPC分类号： A61K31/435

CPC分类号： A61K31/435 ,  Y10S514/813

摘要： A method of training a smoker to cease smoking by administering tropane compounds is provided.

公开(公告)号：EP2773352B1

公开(公告)日：2017-06-28

申请号：EP12856118.0

申请日：2012-12-10

申请人： Research Triangle Institute

发明人： CARROLL, Frank, I. ,  THOMAS, James, B. ,  NAVARRO, Hernan, A. ,  MASCARELLA, S., Wayne ,  RUNYON, Scott, P. ,  JIN, Chunyang ,  KORMOS, Chad, M.

IPC分类号： C07D241/04 ,  C07D401/12 ,  A61K31/495 ,  A61K31/496 ,  A61P25/00 ,  A61P3/00 ,  A61P9/00 ,  A61P15/00 ,  A61P19/02 ,  C07D295/13

CPC分类号： C07D401/12 ,  C07D241/04 ,  C07D295/13

公开(公告)号：EP0993301B1

公开(公告)日：2003-04-09

申请号：EP97940580.0

申请日：1997-08-22

申请人： RESEARCH TRIANGLE INSTITUTE

发明人： KUHAR, Michael, J. ,  CARROLL, Frank, I. ,  BOJA, John, W. ,  LEWIN, Anita, H. ,  ABRAHAM, Philip

IPC分类号： A61K31/46 ,  C07D451/02 ,  A61P25/30 ,  A61P25/16

CPC分类号： C07D451/02 ,  C07F7/2212

摘要： The invention relates to novel compounds which show high affinity for cocaine receptors in the brain, particularly dopamine and serotonin transporter sites. The compounds may be used as imaging or pharmaceutical agents, in the diagnosis and treatment of drug addiction, depression, anorexia and neurodegenerative diseases.

公开(公告)号：EP1079833A1

公开(公告)日：2001-03-07

申请号：EP99924204.3

申请日：1999-05-20

申请人： RESEARCH TRIANGLE INSTITUTE

发明人： CARROLL, Frank, I. ,  KUHAR, Michael, J. ,  BOJA, John, W. ,  LEWIN, Anita, H. ,  ABRAHAM, Philip

IPC分类号： A61K31/46 ,  C07D471/18 ,  C07D451/02 ,  C07D413/04 ,  C07D401/04

CPC分类号： C07D451/02 ,  A61K51/0448 ,  A61K2123/00 ,  C07F7/2212

摘要： The invention relates to novel compounds which show high affinity for cocaine receptors in the brain, particularly dopamine and serotonin transporter sites. The compounds may be used as imaging or pharmaceutical agents, in the diagnosis and treatment of drug addiction, depression, anorexia and neurodegenerative diseases.