公开(公告)号：EP0855906A1

公开(公告)日：1998-08-05

申请号：EP96936782.0

申请日：1996-10-17

申请人： Research Triangle Pharmaceuticals ,  BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM

发明人： HENRIKSEN, Inge, B. ,  MISHRA, Awadesh, K. ,  PACE, Gary, W. ,  JOHNSTON, Keith, P. ,  MAWSON, Simon

IPC分类号： A61J3 ,  A61K9 ,  B01F3 ,  B01F5 ,  B01J2 ,  B01J3 ,  B01F1

CPC分类号： B01J3/008 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1688 ,  B01F1/00 ,  B01F3/1214 ,  B01F3/1271 ,  B01F5/02 ,  B01F5/0287 ,  B01F2003/0064 ,  B01F2003/125 ,  B01F2215/0032 ,  Y02P20/544 ,  Y10S977/896 ,  Y10S977/906

摘要： Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.

公开(公告)号：EP0855906B1

公开(公告)日：2008-02-20

申请号：EP96936782.0

申请日：1996-10-17

申请人： Jagotec AG ,  THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： HENRIKSEN, Inge, B. ,  MISHRA, Awadesh, K. ,  PACE, Gary, W. ,  JOHNSTON, Keith, P. ,  MAWSON, Simon

IPC分类号： A61K9/14

CPC分类号： B01J3/008 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1688 ,  B01F1/00 ,  B01F3/1214 ,  B01F3/1271 ,  B01F5/02 ,  B01F5/0287 ,  B01F2003/0064 ,  B01F2003/125 ,  B01F2215/0032 ,  Y02P20/544 ,  Y10S977/896 ,  Y10S977/906

摘要： Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.