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公开(公告)号：EP1160018B1
公开(公告)日：2009-04-29
申请号：EP01202801.5
申请日：1995-03-29
申请人： Sievers, Robert, E.
发明人： Sievers, Robert E. , Karst, Uwe
CPC分类号： A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/12 , A61K9/124 , A61K9/1688 , A61M15/00 , B01F3/0092 , B01F3/06 , B01F3/068 , B01F5/02 , B01F5/0287 , B01F2003/0064 , B01F2003/061 , B01F2215/0032 , B01J2/04 , B01J3/008 , B05B7/32 , B05B12/1418 , B05D1/025 , B05D2401/90 , Y02P20/544
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公开(公告)号：EP0677332A3
公开(公告)日：1996-10-16
申请号：EP95302078.1
申请日：1995-03-29
申请人： Sievers, Robert, E.
发明人： Sievers, Robert E , Karst, Uwe
IPC分类号： B05B7/24
CPC分类号： A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/12 , A61K9/124 , A61K9/1688 , A61M15/00 , B01F3/0092 , B01F3/06 , B01F3/068 , B01F5/02 , B01F5/0287 , B01F2003/0064 , B01F2003/061 , B01F2215/0032 , B01J2/04 , B01J3/008 , B05B7/32 , B05B12/1418 , B05D1/025 , B05D2401/90 , Y02P20/544
摘要： Methods and apparatuses are provided for forming fine particles of a desired substance comprising dissolving said substance in a fluid such as water to form a solution and mixing the solution with a second fluid such as supercritical carbon dioxide which becomes a gas upon rapid pressure release, and with which the first fluid is at least partially immiscible, and releasing the pressure to form an air-borne dispersion or aerosol comprising particles having an average diameter between about 0.1 and about 6.5 µm.
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3.发明公开
公开(公告)号：EP1319400A3
公开(公告)日：2003-11-19
申请号：EP03075224.0
申请日：1999-06-18
发明人： Pace, Gary W. , Vachon, Michael G. , Mishra, Awadhesh K. , Henrikson, Inge B. , Krukonis, Val , Godinas, Anthony
CPC分类号： A61K9/10 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1688 , B01F3/1214 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , B01J3/008
摘要： Submicron particles of water-insoluble compounds, particularly drugs, are prepared by simultaneously stabilizing microparticulate suspensions of same with surface modifier molecules by rapid expansion into an aqueous medium from a compressed solution of the compound and surface modifiers in a liquefied gas and optionally homogenizing the aqueous suspension thus formed with a high pressure homogenizer.
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公开(公告)号：EP1160018A3
公开(公告)日：2002-01-09
申请号：EP01202801.5
申请日：1995-03-29
申请人： Sievers, Robert, E.
发明人： Sievers, Robert E. , Karst, Uwe
CPC分类号： A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/12 , A61K9/124 , A61K9/1688 , A61M15/00 , B01F3/0092 , B01F3/06 , B01F3/068 , B01F5/02 , B01F5/0287 , B01F2003/0064 , B01F2003/061 , B01F2215/0032 , B01J2/04 , B01J3/008 , B05B7/32 , B05B12/1418 , B05D1/025 , B05D2401/90 , Y02P20/544
摘要： A method and an apparatus is provided for forming fine particles of a substance, comprising: (a) mixing a first nongaseous supercritical fluid, a solution or suspension of said substance in a second nongaseous fluid, and a third nongaseous fluid to form a composition; and (b) reducing the pressure on said composition whereby a dispersion of said fine particles of said substance is formed; wherein the first and second nongaseous fluids are immiscible and wherein the substance comprises a physiologically active composition.
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5.发明公开PROCESS FOR THE MANUFACTURE OF (SUB)MICRON SIZED PARTICLES BY DISSOLVING IN COMPRESSED GAS AND SURFACTANTS 有权过程不到大测微颗粒的制备爆破成气体压力和表面活性物质
公开(公告)号：EP1071402A1
公开(公告)日：2001-01-31
申请号：EP99919195.0
申请日：1999-04-06
发明人： BAUSCH, Alexander , HIDBER, Pirmin
CPC分类号： B01F3/1214 , A61K9/14 , A61K9/145 , A61K9/1688 , B01F3/1271 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , B01J2/04 , B01J3/008 , B01J13/02 , Y02P20/544 , Y10S977/906
摘要： The present invention relates to a process for manufacturing a pulverous preparation of a (sub)micron-sized biologically active compound comprising the steps of: (1) dissolving a biologically active compound under elevated pressure in a compressed gas, liquid or supercritical fluid containing a surface modifier; or in compressed dimethylether optionally containing a surface modifier; (2a) rapidly expanding the compressed solution of step (1) thereby precipitating the dissolved compound; or (2b) spraying the compressed solution of step (1) into an antisolvant phase optionally containing a surface modifier under vacuum, atmospheric pressure or elevated pressure; and (3) optionally converting the antisolvant phase of step (2b) into a pulverous preparation using conventional powder processing techniques. With the process according to the present invention formation of aggregations or flocculations of particles dissolved in the supercritical solution is prevented; moreover, the addition of cosolvents is not required, thus increasing the stabilisation of the suspension on an industrial scale.
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6.发明授权PROCESSES TO GENERATE PARTICLES OF WATER-INSOLUBLE COMPOUNDS OF UP TO 2000 NM IN SIZE 有权新工艺颗粒制造水溶性成分的大小范围2000海里
公开(公告)号：EP1089714B1
公开(公告)日：2003-03-05
申请号：EP99930387.8
申请日：1999-06-18
发明人： PACE, Gary, W. , VACHON, G., Michael , MISHRA, K., Awadhesh , HENRIKSEN, Inge, B. , KRUKONIS, Val , GODINAS, Anthony
CPC分类号： A61K9/1688 , A61K9/10 , A61K9/14 , A61K9/145 , A61K9/146 , B01F3/1214 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , B01J3/008 , Y10S977/773 , Y10S977/801 , Y10S977/906
摘要： Submicron particles of water-insoluble compounds, particularly drugs, are prepared by simultaneously stabilizing microparticulate suspensions of same with surface modifier molecules by rapid expansion into an aqueous medium from a compressed solution of the compound and surface modifiers in a liquefied gas and optionally homogenizing the aqueous suspension thus formed with a high pressure homogenizer.
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公开(公告)号：EP0677332B1
公开(公告)日：2002-02-27
申请号：EP95302078.1
申请日：1995-03-29
申请人： Sievers, Robert, E.
发明人： Sievers, Robert E , Karst, Uwe
CPC分类号： A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/12 , A61K9/124 , A61K9/1688 , A61M15/00 , B01F3/0092 , B01F3/06 , B01F3/068 , B01F5/02 , B01F5/0287 , B01F2003/0064 , B01F2003/061 , B01F2215/0032 , B01J2/04 , B01J3/008 , B05B7/32 , B05B12/1418 , B05D1/025 , B05D2401/90 , Y02P20/544
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8.发明公开Method and apparatus for fine particle formation 失效Verfahren und Vorrichtung zur Erzeugung feiner Partikel
公开(公告)号：EP1160018A2
公开(公告)日：2001-12-05
申请号：EP01202801.5
申请日：1995-03-29
申请人： Sievers, Robert, E.
IPC分类号： B05D1/02
CPC分类号： A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/12 , A61K9/124 , A61K9/1688 , A61M15/00 , B01F3/0092 , B01F3/06 , B01F3/068 , B01F5/02 , B01F5/0287 , B01F2003/0064 , B01F2003/061 , B01F2215/0032 , B01J2/04 , B01J3/008 , B05B7/32 , B05B12/1418 , B05D1/025 , B05D2401/90 , Y02P20/544
摘要： A method and an apparatus is provided for forming fine particles of a substance, comprising:
(a) mixing a first nongaseous supercritical fluid, a solution or suspension of said substance in a second nongaseous fluid, and a third nongaseous fluid to form a composition; and
(b) reducing the pressure on said composition whereby a dispersion of said fine particles of said substance is formed;
wherein the first and second nongaseous fluids are immiscible and wherein the substance comprises a physiologically active composition.摘要翻译： 提供用于形成物质细颗粒的方法和装置，包括：（a）将第一非气态超临界流体，所述物质的溶液或悬浮液与第二非气态流体混合以形成组合物; 和（b）降低所述组合物的压力，由此形成所述物质的所述细颗粒的分散体; 其中所述第一和第二非气态流体是不混溶的，并且其中所述物质包含生理活性组合物。
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公开(公告)号：EP0855906B1
公开(公告)日：2008-02-20
申请号：EP96936782.0
申请日：1996-10-17
发明人： HENRIKSEN, Inge, B. , MISHRA, Awadesh, K. , PACE, Gary, W. , JOHNSTON, Keith, P. , MAWSON, Simon
IPC分类号： A61K9/14
CPC分类号： B01J3/008 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1688 , B01F1/00 , B01F3/1214 , B01F3/1271 , B01F5/02 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , Y02P20/544 , Y10S977/896 , Y10S977/906
摘要： Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.
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10.发明公开
公开(公告)号：EP1319400A2
公开(公告)日：2003-06-18
申请号：EP03075224.0
申请日：1999-06-18
发明人： Pace, Gary W. , Vachon, Michael G. , Mishra, Awadhesh K. , Henrikson, Inge B. , Krukonis, Val , Godinas, Anthony
CPC分类号： A61K9/10 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1688 , B01F3/1214 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , B01J3/008
摘要： Submicron particles of water-insoluble compounds, particularly drugs, are prepared by simultaneously stabilizing microparticulate suspensions of same with surface modifier molecules by rapid expansion into an aqueous medium from a compressed solution of the compound and surface modifiers in a liquefied gas and optionally homogenizing the aqueous suspension thus formed with a high pressure homogenizer.
摘要翻译： 水不溶性化合物的亚微米颗粒，特别是药物，是通过同时用表面改性剂分子稳定其微粒悬浮液，通过在液化气体中从化合物和表面改性剂的压缩溶液中快速膨胀成水性介质，并任选地均化水溶液 由此用高压均化器形成悬浮液。
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