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公开(公告)号：EP3201179A1
公开(公告)日：2017-08-09
申请号：EP15782017.6
申请日：2015-10-01
IPC分类号： C07D213/74 , A61K31/44 , A61P29/00 , A61K31/506 , A61K31/675 , A61K31/7052 , C07D213/80 , C07D401/12 , C07H15/08 , C07D239/47 , C07D413/12 , C07D453/02 , C07F9/09 , C07F9/30 , C07F9/32 , C07F9/40
CPC分类号： C07D213/74 , A61K31/4375 , A61K31/44 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/553 , A61K31/635 , A61K31/675 , A61K31/7052 , A61K31/706 , A61K45/06 , C07D213/80 , C07D239/47 , C07D401/12 , C07D405/12 , C07D413/12 , C07D453/02 , C07F9/587 , C07F9/588 , C07F9/65127 , C07F9/65583 , C07H13/08 , C07H15/26 , C07H19/048 , A61K2300/00
摘要： There are provided compounds of formula I, wherein R1A to R1E, R2 to R4, R5a, L and X1 to X3 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
摘要翻译： 其中Qx表示-C（O）OC1-4烷基或其盐或被保护的衍生物，以及可用于制备具有抗炎活性的化合物的其它化合物（例如通过抑制一种或多种 ：p38丝裂原活化蛋白激酶家族; Syk激酶;和酪氨酸激酶Src家族成员），并且已用于治疗，包括药物联合用药，特别是用于治疗炎性疾病，包括肺部炎症性疾病 ，眼睛和肠子。
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2.发明公开
公开(公告)号：EP2981535A1
公开(公告)日：2016-02-10
申请号：EP14716378.6
申请日：2014-04-01
发明人： FYFE, Matthew Colin Thor , THOM, Stephen Malcolm , BAKER, Thomas Matthew , HARBOTTLE, Gareth William , HASIMBEGOVIC, Vedran , MEGHANI, Premji , RIGBY, Aaron , SAMBROOK-SMITH, Colin
IPC分类号： C07D403/12 , C07D405/14 , C07D213/74 , C07D401/12 , C07D405/12 , C07D413/12 , A61K31/505 , C07D239/47
CPC分类号： C07C317/48 , A61K31/44 , A61K31/4427 , A61K31/444 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/553 , C07C311/08 , C07C317/28 , C07D211/86 , C07D213/74 , C07D233/90 , C07D239/47 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12
摘要： There is provided a compound of formula I, which compound has antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases, e.g., Src and Lck) and has use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
摘要翻译： 提供式I化合物，该化合物具有抗炎活性（例如通过抑制p38丝裂原活化蛋白激酶的家族中的一个或多个成员; Syk激酶;以及酪氨酸激酶Src家族的成员， 例如Src和Lck），并且用于治疗，包括药物组合，特别是用于治疗包括肺，眼和肠的炎性疾病的炎性疾病。
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公开(公告)号：EP3083604A1
公开(公告)日：2016-10-26
申请号：EP14815839.7
申请日：2014-12-19
发明人： FYFE, Matthew Colin Thor , THOM, Stephen Malcolm , BAKER, Thomas Matthew , HARBOTTLE, Gareth William , HASIMBEGOVIC, Vedran , RIGBY, Aaron
IPC分类号： C07D403/12 , A61K31/44 , A61K31/4427 , A61K31/505 , A61K31/506 , C07D213/74 , C07D213/75 , C07F9/53 , C07D401/02 , C07D401/12 , C07D405/12 , C07D239/47 , C07D413/12
CPC分类号： C07F9/65127 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/675 , C07D213/74 , C07D213/75 , C07D239/47 , C07D401/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07F9/582 , C07F9/588 , C07F9/65122 , C07F9/65583 , C07F9/65586
摘要： There are provided compounds of formula I, wherein R1, R1A, R1C to R1E, Ra, Rb, X1, E and G have meanings given in the description, which compounds have antiinflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
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