公开(公告)号：EP4389144A1

公开(公告)日：2024-06-26

申请号：EP22871115.6

申请日：2022-09-20

申请人： Niigata University

发明人： MAEKAWA Tomoki ,  TABETA Koichi ,  TERAO Yutaka ,  TAMURA Hikaru

IPC分类号： A61K45/00 ,  A61K31/7048 ,  A61K31/7052 ,  A61P1/02 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P31/04

CPC分类号： A61P29/00 ,  A61P19/02 ,  A61P19/10 ,  A61P19/00 ,  A61K45/00 ,  A61K31/7048 ,  A61P11/00 ,  A61K31/7052 ,  A61P1/02 ,  A61P31/04

摘要： A regenerative agent for bone tissue and lung tissue contains a macrolide antimicrobial agent as an active ingredient. The macrolide antimicrobial agent may be one or more selected from the group consisting of erythromycin, azithromycin, and clarithromycin. The regenerative agent for bone tissue and lung tissue may be locally administered to bone tissue or lung tissue. A pharmaceutical composition for regenerating bone tissue and lung tissue contains the regenerative agent for bone tissue and lung tissue, and a pharmaceutically acceptable carrier.

公开(公告)号：EP4374848A1

公开(公告)日：2024-05-29

申请号：EP22845427.8

申请日：2022-07-22

申请人： Shanghai Bao Pharmaceuticals Co., Ltd.

发明人： LIU, Yanjun ,  WANG, Zheng ,  LU, Lin ,  ZHU, Zhen

IPC分类号： A61K9/00 ,  A61K45/06 ,  A61K38/46

CPC分类号： A61K47/42 ,  A61K47/20 ,  A61K47/10 ,  A61K9/00 ,  A61K47/26 ,  A61K31/407 ,  A61K9/19 ,  A61P31/04 ,  A61K31/546 ,  A61K38/47 ,  A61K9/08 ,  A61K31/7052 ,  A61K31/545 ,  A61K38/46 ,  A61K45/06 ,  Y02A50/30

摘要： The present invention discloses an antibiotic pharmaceutical composition for intradermal or subcutaneous administration, which comprises an antibiotic and hyaluronidase (HAase). The present invention further relates to a kit comprising the pharmaceutical composition, a method for preparing the kit, and use of the pharmaceutical composition and the kit.

公开(公告)号：EP2475391B1

公开(公告)日：2018-09-12

申请号：EP10816084.7

申请日：2010-09-09

申请人： Centrose, LLC

发明人： PRUDENT, James R. ,  THORSON, Jon S. ,  BOLLETTIERI, Jill, Hutchinson ,  HUTCHINSON, Charles B.

IPC分类号： A61K39/395 ,  C12P21/00 ,  A61P31/00 ,  A61P35/00 ,  A61K31/7052 ,  A61K47/68

CPC分类号： C07K16/28 ,  A61K31/704 ,  A61K31/7052 ,  A61K47/557 ,  A61K47/60 ,  A61K47/6803 ,  A61K47/6807 ,  A61K47/6843 ,  A61K47/6849 ,  A61K47/6851 ,  C07K2317/92

摘要： The present invention relates to, inter alia, extracellular drug conjugates (EDC) in which an antibody or other targeting agent (e.g. a targeting moiety) is linked to a drug through a linker (e.g. a non-cleavable linker). These conjugates are useful in the treatment of disease and/or as a tool in the evaluation of biological systems.

公开(公告)号：EP3364974A2

公开(公告)日：2018-08-29

申请号：EP16856437.5

申请日：2016-10-17

申请人： The Children's Medical Center Corporation

发明人： AGARWAL, Suneet ,  MOON, Diane ,  BOYRAZ, Baris ,  SEGAL, Matthew

IPC分类号： A61K31/47 ,  A61K31/381

CPC分类号： C12N9/1241 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/7052 ,  A61K31/713 ,  A61K45/06 ,  C07K2319/00 ,  C07K2319/80 ,  C12N9/16 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12Y207/07019 ,  C12Y301/13004 ,  A61K2300/00

摘要： The disclosure relates to treating and diagnosing telomere diseases, and methods of screening agents for treating and diagnosing telomere diseases.

公开(公告)号：EP2609812B1

公开(公告)日：2018-08-29

申请号：EP13161090.9

申请日：2008-03-04

申请人： N.V. Nutricia

发明人： De Kort, Esther Jacqueline ,  Hageman, Robert Johan Joseph ,  Groenendijk, Martine ,  Kamphuis, Patrick Joseph Gerardus Hendrikus

IPC分类号： A61K31/7052 ,  A61K31/7072 ,  A61K35/60 ,  A61K47/36 ,  A61K47/38 ,  A61P25/28 ,  A23L29/262 ,  A23L29/269

CPC分类号： A61K47/38 ,  A23L29/262 ,  A23L29/269 ,  A23L29/272 ,  A23L33/115 ,  A23L33/13 ,  A23L33/17 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0095 ,  A61K31/7052 ,  A61K31/7072 ,  A61K33/06 ,  A61K35/60 ,  A61K38/02 ,  A61K47/36 ,  A61K47/42 ,  A61K47/44 ,  A61K2300/00 ,  A23V2200/322 ,  A23V2200/302 ,  A23V2250/712 ,  A23V2250/708 ,  A23V2250/7052 ,  A23V2250/706 ,  A23V2250/714 ,  A23V2250/702 ,  A23V2250/72 ,  A23V2250/1588 ,  A23V2250/1614 ,  A23V2250/1608 ,  A23V2250/1612 ,  A23V2250/1642 ,  A23V2250/1868 ,  A23V2250/187 ,  A23V2250/51082 ,  A23V2250/54246 ,  A23V2250/54252 ,  A23V2250/628 ,  A23V2250/5114

摘要： The invention pertains to a liquid composition for preventing and/or treating memory decline and/or cognitive dysfunction, Alzheimer's, Parkinson's and/or dementia, said composition comprising: (i) at least 50 mg nucleoside and/or nucleotide per 100 ml; (ii) between 0.2 and 10 grams protein per 100 ml; (iii) between 0.05 and 3 wt.% of thickener, based on total weight of the composition. The thickener is preferably selected from the group consisting of cellulose, xanthan gum, gellan gum, alginate, guar gum, locust bean gum, gum karaya, gum tragacanth, carrageenan, and mixtures thereof. The composition preferably has a loss factor tan ´ between 0.1 and 100, as measured at any strain in the range of 1 - 100 % at 0.1 Hz and 20 °C. It is particularly found that a thickener selected from the group consisting of gellan gum, xanthan gum and cellulose greatly reduces sedimentation.

公开(公告)号：EP3208277A4

公开(公告)日：2018-06-13

申请号：EP15850498

申请日：2015-10-13

申请人： AJINOMOTO KK

发明人： TAKAHASHI DAISUKE ,  TORII TAKAYOSHI

IPC分类号： C07F9/6533 ,  A61K31/7052 ,  C07F9/6558 ,  C12N15/09

CPC分类号： C12N15/111 ,  A61K31/7052 ,  C07F9/6533 ,  C07F9/6558 ,  C12N15/09 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/3233 ,  Y02P20/55

摘要： The present invention relates to a liquid-phase synthesis method of morpholino oligonucleotide, which includes subjecting a reaction mixture of a condensation reaction to an extraction operation and separating morpholino oligonucleotide as a resultant product to the organic layer side. According to the present invention, a method capable of producing morpholino oligonucleotide efficiently in a high yield by a liquid-phase synthesis method can be provided.

公开(公告)号：EP3325494A1

公开(公告)日：2018-05-30

申请号：EP16747628.2

申请日：2016-07-19

申请人： Yeda Research and Development Co., Ltd.

发明人： KARLISH, Steven J.D. ,  KATZ, Adriana ,  TAL, Daniel M. ,  MARCOVICH, Arie

IPC分类号： C07J19/00 ,  C07H17/00 ,  A61K31/7052 ,  A61P27/06 ,  A61P9/00

CPC分类号： A61K31/7052 ,  A61P9/00 ,  A61P27/06 ,  C07H17/00 ,  C07J19/005 ,  C07J43/003

摘要： Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.

公开(公告)号：EP3323419A1

公开(公告)日：2018-05-23

申请号：EP16824362.4

申请日：2016-07-07

申请人： Osaka University

发明人： NAKAMORI, Masayuki ,  MOCHIZUKI, Hideki

IPC分类号： A61K31/7048 ,  A61K31/7052 ,  A61P21/04 ,  A61P43/00

CPC分类号： A61K31/7048 ,  A61K31/7052 ,  A61P21/00

摘要： The present invention provides a therapeutic agent for myotonic dystrophy which inhibits aberrant splicing responsible for myotonic dystrophy, resulting in an increase in a normally spliced product and thus improvement in a symptom of myotonic dystrophy, and is highly safe for use in long-term administration. The therapeutic agent for myotonic dystrophy comprises, as an active ingredient, at least one compound selected from the group consisting of erythromycin, clarithromycin and azithromycin, a pharmaceutically acceptable salt or hydrate thereof, or a prodrug thereof.

公开(公告)号：EP2362727B1

公开(公告)日：2018-04-11

申请号：EP09822827.3

申请日：2009-10-24

申请人： Cempra Pharmaceuticals, Inc.

发明人： PEREIRA, David, E. ,  FERNANDES, Prabhavathi, B.

IPC分类号： A61K31/7048 ,  A61K31/7052 ,  C07H17/08 ,  A61K31/424 ,  A61K31/7056 ,  C07D498/04 ,  A61P31/04

CPC分类号： A61K31/7048 ,  A61K31/424 ,  A61K31/70 ,  A61K31/7052 ,  A61K31/7056 ,  C07D498/04 ,  C07H17/08 ,  Y02A50/406 ,  Y02A50/47 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/483

摘要： Use of macrolide and ketolide antibiotics for the treatment of acute exposure and diseases caused by biodefence pathogens is described.

公开(公告)号：EP2928476B1

公开(公告)日：2018-02-14

申请号：EP13811325.3

申请日：2013-12-05

申请人： GlycoMimetics, Inc.

发明人： MAGNANI, John, L.

IPC分类号： A61K31/7034 ,  A61P35/00

CPC分类号： A61K31/7034 ,  A61K31/7048 ,  A61K31/7052 ,  A61K31/7056 ,  A61K31/765 ,  A61K45/06

摘要： Methods are provided herein for use of E-selectin antagonists for mobilizing cells, such as hematopoietic cells, hematopoietic stem cells and progenitor cells, white blood cells, and malignant cells, and hematopoietic tumor cells from the bone marrow. More specifically, methods are provided for using E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers, and peptides for mobilizing cells from the bone marrow to the peripheral vasculature and tissues.