公开(公告)号：EP0965644A3

公开(公告)日：2004-01-07

申请号：EP99304444.5

申请日：1999-06-08

申请人： RheoGene Holdings Inc.

发明人： Carlson, Glenn Richard ,  Cress, Dean Ervin ,  Dhadialla, Tarlochan Singh ,  Hormann, Robert Eugene ,  Le, Dat Phat

IPC分类号： C12N15/82 ,  C12N15/85 ,  C07K14/72 ,  C07K14/705 ,  C12P21/00 ,  C12Q1/68 ,  C07C243/38 ,  C07D319/20 ,  C07D307/79 ,  C07D319/18

CPC分类号： C07D319/18 ,  C07C243/38 ,  C12Q1/6897

摘要： This invention relates to an improved method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The improvement resides in a select group of non-steroid ligands which show improved activity over known ligands.