-
公开(公告)号：EP3220137B1
公开(公告)日：2019-01-23
申请号：EP16160136.4
申请日：2016-03-14
IPC分类号： G01N27/327 , C12Q1/00
-
公开(公告)号：EP3220137A1
公开(公告)日：2017-09-20
申请号：EP16160136.4
申请日：2016-03-14
IPC分类号： G01N27/327 , C12Q1/00
CPC分类号： G01N27/3274 , C12Q1/006
摘要： A method for detecting an interferent contribution in a biosensor, wherein the biosensor has a first electrode (112), a second electrode, and a third electrode (114), wherein the first electrode (112) and the second electrode are covered by a membrane, wherein the first electrode (112) further includes an enzyme or wherein the first electrode (112) is covered by an enzyme layer. Further, the first electrode (112), the second electrode, and the third electrode (114) are connected via a potentiostat, wherein, in a normal operational mode, via the potentiostat an electrical potential difference is applied between the first electrode (112) and the second electrode in a manner that the first electrode (112) allows for oxidative processes and the third electrode (114) allows for reductive processes. The method comprises the steps of:
a) switching from the normal operational mode to an interferent detection mode, wherein, in the interferent detection mode, the electrical potential difference between the first electrode (112) and the second electrode is altered for a limited period of time in a manner that the third electrode (114) allows for oxidative processes;
b) measuring a current-voltage characteristic (110) of the third electrode (114); and
c) determining the interferent contribution in the biosensor by evaluating the current-voltage characteristic (110) of the third electrode (114).
The method allows deducting the presence and, preferably, the amount of the interferent in an unambiguous way and is, generally, applicable in case of more than one kind of interferent. Neither additional working electrodes nor supplementary circuit components are required. The method is implementable within sensor electronics architectures of standard biosensors and, thus, applicable in already existing biosensor systems.摘要翻译： 一种用于检测生物传感器中的干扰物贡献的方法，其中生物传感器具有第一电极（112），第二电极和第三电极（114），其中第一电极（112）和第二电极被膜 其中所述第一电极（112）还包含酶或其中所述第一电极（112）被酶层覆盖。 此外，第一电极（112），第二电极和第三电极（114）经由恒电位器连接，其中在正常操作模式中，经由稳压器在第一电极（112）和第二电极 和第二电极以第一电极（112）允许氧化过程并且第三电极（114）允许还原过程的方式。 该方法包括以下步骤：a）从正常操作模式切换到干扰物检测模式，其中在干扰物检测模式中，第一电极（112）和第二电极之间的电位差在有限的时间内改变 的时间以第三电极（114）允许氧化过程的方式进行; b）测量所述第三电极（114）的电流 - 电压特性曲线（110）; 和c）通过评估第三电极（114）的电流 - 电压特性（110）来确定生物传感器中的干扰物贡献。 该方法允许以明确的方式扣除干扰物的存在和优选地量，并且通常适用于多于一种干扰物的情况。 无需额外的工作电极和辅助电路元件。 该方法可在标准生物传感器的传感器电子体系结构内实施，因此可应用于已有的生物传感器系统。
-
公开(公告)号：EP4082436A1
公开(公告)日：2022-11-02
申请号：EP21171239.3
申请日：2021-04-29
IPC分类号： A61B5/1473 , A61B5/1486 , A61B5/1495
摘要： A method for determining a reliability of an analyte sensor (110) is proposed. The analyte sensor (110) is an in vivo sensor. The method comprises the steps:
a) measuring at least one first temperature dependent signal;
b) measuring at least one second temperature dependent signal which is different from the first temperature dependent signal and which is related to a current flow in the analyte sensor (110);
c) correlating the first temperature dependent signal and the second temperature dependent signal for determining the reliability of the analyte sensor (110).-
4.发明公开
公开(公告)号：EP4371482A3
公开(公告)日：2024-07-17
申请号：EP24168378.8
申请日：2017-06-28
发明人： Ringemann, Christian
CPC分类号： A61B5/7221 , A61B5/14532 , A61B5/746
摘要： A method (110) is disclosed. The method (110) comprises the steps of:
a) receiving a measured analyte value (114) from a biosensor (116), wherein the biosensor (116) is adapted for measuring the analyte values (114), and wherein the biosensor (116) is comprised in a continuous monitoring system (118) or controlled by the continuous monitoring system (118);
b) determining at least two impact parameters (136), wherein each of the impact parameters (136) is influenced by an operational status of the continuous monitoring system (118), and wherein each of the impact parameters (136) is capable of exerting an influence (138) on a signal quality of the biosensor (116), wherein the influence of each of the impact parameters (136) on the signal quality of the biosensor (116) is expressed by a weight (144) being assigned to each of the impact parameters (136); and
c) determining the signal quality degree (112) associated with the measured analyte value (114) by combining the weights (144) and the corresponding impact parameters (136); and providing the signal quality degree (112) associated with the analyte value (114),
wherein the amount of insulin (150) is determined from at least one data pair (146), wherein the data pair (146) comprises the measured analyte value (114) from the biosensor (116) and the signal quality degree (112) associated with the measured analyte value (114), wherein in an event in which the signal quality degree (112) falls below a first predefined quality threshold, an alarm is suppressed and activated after the signal quality degree (112) meets a second predefined quality threshold, wherein the second predefined quality threshold is higher or lower compared to the first predefined quality threshold, or wherein, in an event in which the signal quality degree (112) falls below a predefined quality threshold, an alarm is antedated.-
5.发明公开
公开(公告)号：EP4371482A2
公开(公告)日：2024-05-22
申请号：EP24168378.8
申请日：2017-06-28
发明人： Ringemann, Christian
IPC分类号： A61B5/145
CPC分类号： A61B5/7221 , A61B5/14532
摘要： A method (110) is disclosed. The method (110) comprises the steps of:
a) receiving a measured analyte value (114) from a biosensor (116), wherein the biosensor (116) is adapted for measuring the analyte values (114), and wherein the biosensor (116) is comprised in a continuous monitoring system (118) or controlled by the continuous monitoring system (118);
b) determining at least two impact parameters (136), wherein each of the impact parameters (136) is influenced by an operational status of the continuous monitoring system (118), and wherein each of the impact parameters (136) is capable of exerting an influence (138) on a signal quality of the biosensor (116), wherein the influence of each of the impact parameters (136) on the signal quality of the biosensor (116) is expressed by a weight (144) being assigned to each of the impact parameters (136); and
c) determining the signal quality degree (112) associated with the measured analyte value (114) by combining the weights (144) and the corresponding impact parameters (136); and providing the signal quality degree (112) associated with the analyte value (114),
wherein the amount of insulin (150) is determined from at least one data pair (146), wherein the data pair (146) comprises the measured analyte value (114) from the biosensor (116) and the signal quality degree (112) associated with the measured analyte value (114), wherein in an event in which the signal quality degree (112) falls below a first predefined quality threshold, an alarm is suppressed and activated after the signal quality degree (112) meets a second predefined quality threshold, wherein the second predefined quality threshold is higher or lower compared to the first predefined quality threshold, or wherein, in an event in which the signal quality degree (112) falls below a predefined quality threshold, an alarm is antedated.-
公开(公告)号：EP4075444A1
公开(公告)日：2022-10-19
申请号：EP21168362.8
申请日：2021-04-14
发明人： Adelberger, Daniel , Del Re, Luigi , Reiterer, Florian , Ringemann, Christian , Schrangl, Patrick
摘要： The invention relates to a method (100) for predicting blood glucose levels, in particular for postprandial blood glucose level prediction, the method being computer-implemented and comprising: receiving (101) a first medical data set of a patient covering a time range, said first medical data set comprising glucose data and further other medical data of said patient, extracting (102) a second medical data set from said first medical data set, wherein the second medical data set is a subset of the first medical data set and wherein the extracting comprises at least one of: identifying (103) duplicates in the first medical data set and removing identified duplicates, identifying (104) data values that lie above a predefined maximum threshold data value or identifying (105) data values that lie below a predefined minimum threshold data value and removing data associated to said identified data values, identifying (106) data values that differ from predetermined expected data values by more than a predetermined amount and removing data associated to said identified data values, identifying (107) incomplete data for which data values are missing and removing identified incomplete data, identifying (108) at least one predetermined time-dependent data pattern and removing data associated to said identified time-dependent data pattern, providing (109) the extracted second medical data set as input to a blood glucose level prediction model, and predicting (110) future blood glucose levels of the patient using the output of the blood glucose level prediction model based on the second medical data set.
-
7.发明公开Method / device for generating a corrected value of an analyte concentration in a sample of a body fluid 审中-公开用于体液样品中产生的分析物浓度的校正值的方法/设备
公开(公告)号：EP2781919A1
公开(公告)日：2014-09-24
申请号：EP13159901.1
申请日：2013-03-19
IPC分类号： G01N33/543
CPC分类号： G01N33/5094 , G01N21/75 , G01N27/3272 , G01N27/3274 , G01N33/525 , G01N33/558 , G01N33/66
摘要： A method for detecting an analyte in a body fluid is disclosed. The method has the following steps:
a) applying a sample (122) of the body fluid to a test element (120), said test element (120) comprising at least
(i) a test field (128) comprising at least one test material (130) adapted to change at least one measurable property in the presence of the analyte,
(ii) a capillary element (126) adapted to guide the sample (122) across said test field (128) in a flow direction (146),
(iii) a first and a second measurement location (158, 160) within said test field (128), wherein the second measurement location (160) is offset from the first measurement location (158) in the flow direction (146);
b) measuring the measurable property in said at least one first measurement location (158), thereby generating at least one first measurement value;
c) measuring the measurable property in said at least one second measurement location (160), thereby generating at least one second measurement value;
d) detecting the analyte by using an evaluation algorithm having at least two input variables, wherein
(i) at least one first input variable of the at least two input variables includes an information on a difference between the first measurement value and the second measurement value, and
(ii) at least one second input variable of the at least two input variables includes a measurement information on an analyte-induced change of the measurable property of the test material (130) in at least part of the test field (128).摘要翻译： 一种用于在体液的分析物的检测方法是游离缺失盘。 该方法具有以下步骤：a）将所述体液的样品（122）的测试元件（120），所述测试元件（120），包括至少（ⅰ）一个测试场（128），包括至少一个测试 材料（130）angepasst改变至少一种可测量的属性中的分析物的存在，（ⅱ）的毛细管元件（126）angepasst引导穿过所述测试场（128）的样本（122）中的流动方向（146） ，（iii）所述测试场（128），其中，所述第二测量位置（160）从在流动方向（146）的第一测量位置（158）的偏移量内的第一和第二测量位置（158，160）; b）测量在至少一个所述第一测量位置（158）的可测量特性，由此产生至少一个第一测量值; c）测量在所述至少一个第二所述测量位置（160）的可测量特性，从而产生至少一个第二测量值; D）通过使用具有至少两个输入变量，worin（i）所述至少两个输入变量中的至少一个第一输入变量评估算法检测所述分析物包括在所述第一测量值和第二测量值之间的差的信息 ，和（ii）在所述至少两个输入变量中的至少一个第二输入变量包括到测试材料（130）在测试场的至少一部分的可测量特性的分析物引起的变化的测量信息（128） ，
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.015 秒)
