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公开(公告)号:EP3505626B1
公开(公告)日:2024-10-09
申请号:EP17846059.8
申请日:2017-08-07
IPC分类号: C12N9/04 , C12M1/40 , C12Q1/32 , G01N27/327 , G01N27/416 , C12Q1/00
CPC分类号: C12M1/40 , C12Q1/32 , G01N27/327 , G01N27/416 , C12N9/0006 , C12Y101/01022 , C12Q1/006
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公开(公告)号:EP4361631A3
公开(公告)日:2024-07-17
申请号:EP24164549.8
申请日:2018-03-06
发明人: RAO, Ashwin K. , GOTTLIEB, Rebecca K. , ONG, Quyen
IPC分类号: G01N33/52
CPC分类号: A61B5/14532 , A61B5/14539 , A61B5/14517 , A61B5/6833 , A61B5/14546 , A61B5/1486 , C12Q1/006 , A61B5/6832 , A61B2560/041220130101 , C12Q1/54 , G01N33/526 , G01N2800/04220130101
摘要: Described here are patches and methods for measuring glucose in sweat (and tears and the like). In general, the patches comprise an adhesive layer adapted to bond to skin of an individual, a substrate layer disposed over the adhesive layer and comprising a glucose sensing complex including a chromogen that changes color in the presence of certain concentrations of glucose, and a cover. In typical embodiments, the substrate layer has elements formed to direct and accumulate sweat that migrates from the skin of the individual to the glucose sensing complex. Methods of using the invention can comprise cleaning the skin surface, collecting sweat in a patch comprising this microfluidic constellation of elements, and observing concentrations of glucose collected in the sweat, for example either visually, or by using a smartphone or other computer processing device.
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公开(公告)号:EP4365912A2
公开(公告)日:2024-05-08
申请号:EP24151950.3
申请日:2018-01-18
申请人: DexCom, Inc.
发明人: Wang, Shanger , Headen, Devon, M. , Böhm, Sebastian , Lee, Ted Tang , Hughes, Jonathan , Simpson, Peter C. , Zou, Jiong
IPC分类号: G16H40/67
CPC分类号: A61B5/14865 , G01N27/3271 , A61B5/0022 , C12Q1/006 , A61B2562/12520130101 , C12Q1/002 , A61B5/14532 , A61B2562/16420130101 , A61B5/14546 , G16H40/67 , Y02A90/10
摘要: Flexible analyte sensors are provided. Flexible analyte sensors may be flexible continuous analyte sensors that facilitate continuous monitoring of an analyte such as blood glucose. The flexible analyte sensor may have a relatively flexible conductive or non-conductive core, may be formed from a plurality of substantially planar layers, or may be configured to transform from a freestanding sensor ex vivo to a non-freestanding sensor in vivo.
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公开(公告)号:EP2511698B1
公开(公告)日:2018-11-28
申请号:EP12173297.8
申请日:2009-01-19
申请人: LifeScan, Inc.
IPC分类号: G01N27/327
CPC分类号: G01N27/4163 , C12Q1/006 , G01N27/3274
摘要: Methods of determining a corrected analyte concentration in view of some error source are provided herein. The methods can be utilized for the determination of various analytes and/or various sources of error. In one example, the method can be configured to determine a corrected glucose concentration in view of an extreme level of hematocrit found within the sample. In other embodiments, methods are provided for identifying various system errors and/or defects. For example, such errors can include partial-fill or double-fill situations, high track resistance, and/or sample leakage. Systems are also provided for determining a corrected analyte concentration and/or detecting some system error.
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公开(公告)号:EP3219807B1
公开(公告)日:2018-11-14
申请号:EP17169444.1
申请日:2013-03-27
IPC分类号: C12Q1/00
摘要: The present invention relates to an electrode system for measuring the concentration of an analyte under in-vivo conditions, comprising an electrode with immobilized enzyme molecules and an improved diffusion barrier that controls diffusion of the analyte from body fluid surrounding the electrode system to the enzyme molecules.
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公开(公告)号:EP3343213A3
公开(公告)日:2018-08-29
申请号:EP18151485.2
申请日:2010-08-30
IPC分类号: G01N27/327 , G01N21/27 , G01N21/75 , G01N27/416 , C12Q1/00 , C12Q1/32 , G01N21/84
CPC分类号: G01N27/3272 , C12Q1/006 , C12Q1/32 , G01N21/8483
摘要: The present invention provides a sensor for detecting or quantifying a target substance contained in a liquid sample. The sensor comprises a quinone compound that accepts electrons released as a result of dehydrogenation or oxidization of the target substance by the enzyme; and at least a pair of electrodes, wherein the quinone compound contains a quinone and a substituent, wherein the substituent is hydrophilic. The quinone compound has a lower redox potential than conventional substances, so interfering substances have less effect on detection results with this sensor, particularly the redox potential of the quinone compound measured using a silver/silver chloride (saturated potassium chloride) electrode as a reference electrode is more negative than the oxidization potential of ascorbic acid.
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公开(公告)号:EP3002586B1
公开(公告)日:2018-05-02
申请号:EP15193531.9
申请日:2011-05-06
申请人: PA Knowledge Limited
发明人: NOBLE, Michael , NELSON, Craig , HUMPHRIES, Mark , LLOYD, Carys , EDINGTON, David , RIPPETH, John
IPC分类号: G01N33/487
CPC分类号: G01N27/3272 , C12Q1/006 , C12Q1/54 , G01N27/3274 , G01N33/4915 , G01N2496/00
摘要: A method and device are provided for measuring a level of a clinically relevant analyte (such as glucose) in a fluid (such as blood). The device includes a flow path for conducting said fluid through the device; a detection chamber arranged on said flow path; and detector means arranged to detect analyte levels in the fluid in said chamber, wherein:; said detection chamber contains a predetermined amount of an analyte such that that analyte mixes with fluid in the detection chamber to form, at the detector means, a calibration sample of the fluid at a time after the arrival of the fluid in said detection chamber, and said detector means is arranged to detect a first analyte level of an unadulterated sample of the fluid at a first time which is before the formation of said calibration sample and to detect a second analyte level of said calibration sample at a second time which is after the formation of said calibration sample.
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公开(公告)号:EP2388585B1
公开(公告)日:2018-05-02
申请号:EP11176149.0
申请日:2001-11-30
发明人: Sawada, Yasuhiko , Miyazaki, Shoji , Tokunaga, Hiroyuki , Tokuno, Yoshinobu , Matsumoto, Kazuhiro
IPC分类号: G01N33/487 , G01N27/327 , C12Q1/00
CPC分类号: G01N27/327 , A61B5/1486 , A61B2562/0295 , C12Q1/001 , C12Q1/005 , C12Q1/006 , G01N27/26 , G01N27/3272 , G01N27/3274 , G01N33/48771 , G01N33/5438
摘要: A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltage to the respective electrodes via the connecting terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction, and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.
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公开(公告)号:EP3289344A1
公开(公告)日:2018-03-07
申请号:EP16720528.5
申请日:2016-04-28
IPC分类号: G01N27/327 , C12Q1/00
CPC分类号: G01N15/0656 , C12Q1/005 , C12Q1/006 , G01N27/327 , G01N27/3272
摘要: An electrochemical test device for determining a concentration of one or more analytes in a fluid sample is provided. The electrochemical test device comprises a set of electrodes including two or more working electrodes, each working electrode for determining the concentration of a corresponding analyte, and sensing chemistry for each working electrode, wherein the sensing chemistry for a first of the two or more working electrodes comprises a diaphorase, an electron transfer agent, an NAD(P)+-dependent dehydrogenase and a cofactor for the NAD(P)+-dependent dehydrogenase, wherein at least some of the diaphorase for the first working electrode is disposed in a diaphorase-containing layer which extends over the first working electrode and at least a second of the two or more working electrodes.
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公开(公告)号:EP2266455B1
公开(公告)日:2018-01-31
申请号:EP10180699.0
申请日:2007-03-30
申请人: LifeScan, Inc.
IPC分类号: A61B5/00 , C12Q1/00 , G01N33/487
CPC分类号: A61B5/1486 , C12Q1/006 , G01N27/3274
摘要: Disclosed herein are methods and apparatus for determining analyte concentration in a rapid and accurate manner. The methods include depositing a physiological sample in an electrochemical cell and finding a first and second current transient. Peak current values are obtained from the first and second peak current values and used to reduce the influence of interferents in a current value. Based on this "corrected" current value, an accurate analyte concentration can be determined.
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