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1.发明公开VERFAHREN ZUR SYNTHESE UND SELEKTIVEN BIOKATALYTISCHEN MODIFIZIERUNG VON PEPTIDEN, PEPTIDMIMETIKA UND PROTEINEN 有权METHOD肽，肽模拟物和蛋白质的合成和选择性的生物催化修饰
公开(公告)号：EP1534734A1
公开(公告)日：2005-06-01
申请号：EP03794978.1
申请日：2003-09-01
IPC分类号： C07K1/00
CPC分类号： C07K1/12
摘要： The invention relates to a method for the synthesis of peptides, peptide mimetics and/or proteins and/or for the selective N-terminal modification of peptides, peptide mimetics and/or proteins. Said method comprises the following steps: a) an amino constituent comprising at least one amino acid is prepared, b) a carboxy constituent comprising a leaving group on the carboxyl group is prepared, said carboxy constituent being a compound comprising at least one amino acid or a compound comprising at least one marker group or reporter group, and c) the amino constituent and the carboxy constituent are reacted in a reaction medium comprising at least one ionic liquid, in the presence of a protease, a peptidase and/or a hydrolase, a peptide bond being formed between the amino constituent and the carboxy constituent, splitting off the leaving group.
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2.发明授权VERFAHREN ZUR SYNTHESE UND SELEKTIVEN BIOKATALYTISCHEN MODIFIZIERUNG VON PEPTIDEN, PEPTIDMIMETIKA UND PROTEINEN 有权METHOD肽，肽模拟物和蛋白质的合成和选择性的生物催化修饰
公开(公告)号：EP1534734B1
公开(公告)日：2008-05-07
申请号：EP03794978.1
申请日：2003-09-01
IPC分类号： C07K1/00
CPC分类号： C07K1/12
摘要： The invention relates to a method for the synthesis of peptides, peptide mimetics and/or proteins and/or for the selective N-terminal modification of peptides, peptide mimetics and/or proteins. Said method comprises the following steps: a) an amino constituent comprising at least one amino acid is prepared, b) a carboxy constituent comprising a leaving group on the carboxyl group is prepared, said carboxy constituent being a compound comprising at least one amino acid or a compound comprising at least one marker group or reporter group, and c) the amino constituent and the carboxy constituent are reacted in a reaction medium comprising at least one ionic liquid, in the presence of a protease, a peptidase and/or a hydrolase, a peptide bond being formed between the amino constituent and the carboxy constituent, splitting off the leaving group.
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