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公开(公告)号：EP4193381A1
公开(公告)日：2023-06-14
申请号：EP21758103.2
申请日：2021-08-09
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公开(公告)号：EP4153565A1
公开(公告)日：2023-03-29
申请号：EP21726906.7
申请日：2021-05-19
发明人： HAHN, Robert , HEINDL, Dieter , HOFFMANN, Thomas , JOSEL, Hans-Peter , KOBOLD, Uwe , KUCHELMEISTER, Hannes , LOIBL, Simon Ferdinand , MAZZIER, Daniela , MILIC, Jelena , PRENCIPE, Giuseppe , REMPT, Martin , SEIDEL, Christoph
IPC分类号： C07D213/46 , C07D213/55 , C07D213/61 , C07D213/86 , C07D401/04
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公开(公告)号：EP3183246B1
公开(公告)日：2020-09-23
申请号：EP15753944.6
申请日：2015-08-21
发明人： GEBAUER, Peter , HEINDL, Dieter , HORN, Carina , FOMIN, Maksim
IPC分类号： C07D401/06 , C07D241/40
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公开(公告)号：EP3131882B1
公开(公告)日：2020-07-15
申请号：EP15718466.4
申请日：2015-04-13
发明人： HEINDL, Dieter , NORTMEYER, Christine , GEBAUER, Peter , HUNT DU VALL, Stacy , BAUER-ESPINDOLA, Klaus Andreas
IPC分类号： C07D241/46
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公开(公告)号：EP3562845A2
公开(公告)日：2019-11-06
申请号：EP17832237.6
申请日：2017-12-22
发明人： GERG, Michael , HEINDL, Dieter , HILLRINGHAUS, Lars , HIRZEL, Klaus , HOJER, Caroline Dorothea , HUBER, Florian , JOSEL, Hans-Peter , MEIER, Thomas , SCHRAEML, Michael , VOSS, Edgar
IPC分类号： C07K16/44 , C07D495/04 , G01N33/82 , A61K47/51 , A61K31/4188 , C07K16/00 , C07K16/40 , G01N33/53
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公开(公告)号：EP2931917B1
公开(公告)日：2017-04-05
申请号：EP13802395.7
申请日：2013-12-11
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6853 , C12Q1/6858
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7.发明公开NOVEL COMPOUNDS USEFUL FOR FRET AND METHODS RELATED THERETO 审中-公开ZUGEHÖRIGEVERFAHREN上的VERBINDUNGENFÜRFRE
公开(公告)号：EP3004372A1
公开(公告)日：2016-04-13
申请号：EP14728188.5
申请日：2014-06-04
IPC分类号： C12Q1/00 , C12Q1/26 , G01N33/533 , G01N33/535 , G01N33/542 , G01N33/573 , G01N33/58 , C12Q1/68
CPC分类号： C07H19/207 , C12Q1/26 , G01N21/6428 , G01N33/533 , G01N33/535 , G01N33/542 , G01N33/5735 , G01N33/581 , G01N33/582 , G01N2201/062 , G01N2333/90248
摘要： The invention relates to compounds, which are useful for intramolecular fluorescence resonance energy transfer (FRET), comprising the oxidized form of a carbaNADH-based first fluorophore and a second fluorophore that is excitable at a wave-length of between 445 to 540 nm and that has an emission maximum of greater than 560 nm, and methods, kits and compositions related thereto.
摘要翻译： 本发明还涉及可用于分子内荧光共振能量转移（FRET）的化合物，其包含氧化形式的基于carbaNADH的第一荧光团和第二荧光团，其波长在445至540之间是可激发的 nm，并且具有大于560nm的发射最大值，以及与其相关的方法，试剂盒和组合物。
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公开(公告)号：EP2370450A1
公开(公告)日：2011-10-05
申请号：EP09763860.5
申请日：2009-11-25
CPC分类号： G01N33/5308 , C07F9/6552 , C07F9/65586 , Y02P20/55
摘要： The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic or a specifier is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. By selecting suitable monomers for the synthesis which have a defined stereoconformation compounds of Formula (1) are produced in a stereocontrolled manner.
摘要翻译： 化合物的三价磷原子与试剂反应，形成稳定的磷酸酯模拟物或说明符。 具有含至少一个提供有保护基团的羟基残基的磷原子的亚磷酰胺为此目的与游离羟基反应：在第一个合成循环中，羟基通过可裂解或不可裂解与固体载体连接 连接。 在进一步的合成循环中，羟基通过从生长中的寡聚体上切下保护基而产生。 这导致形成与叠氮化物反应的亚磷酸三酯。 通过选择合适的具有确定的立体构象的合成单体，以立体控制的方式制备式（1）的化合物。
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公开(公告)号：EP1989324B1
公开(公告)日：2011-05-18
申请号：EP07703556.6
申请日：2007-02-23
CPC分类号： C12Q1/6848 , C12Q2549/101 , C12Q2527/125
摘要： The present invention is directed to Synthetic peptide having a length of not more than 30 amino acids comprising a divalent cation binding site. Such a peptide according to the present invention is part of a composition for nucleic acid amplification and provides for a so called hot start effect.
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公开(公告)号：EP1397488A1
公开(公告)日：2004-03-17
申请号：EP02735389.5
申请日：2002-05-28
IPC分类号： C12N9/18 , C12Q1/68 , C12N5/10 , C12N15/62 , C07K16/18 , G01N33/50 , G01N33/53 , A61K48/00 , A61K39/00
CPC分类号： C07D401/12 , C07D219/06 , C07D417/04 , C07D417/14 , C12Q1/28 , G01N33/533 , G01N33/582 , Y10S435/968 , Y10S436/80 , Y10S436/904
摘要： The present invention relates to a chemical compound comprising a light emitting moiety precursor (eg. acridine, luciferine) and a precursor of a leaving group (eg. oxazine, anilide), bound to each other by an amide or by an ester bond and characterized in that the leaving group precursor upon oxidation is converted into the leaving group. The invention also relates to compounds additionally comprising a coupling group to the use of such compounds for labeling of biomolecules and more generally to the use of such compounds in chemiluminescence detection procedures.
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