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公开(公告)号：EP3359966B1
公开(公告)日：2020-01-01
申请号：EP16778831.4
申请日：2016-10-10
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公开(公告)号：EP2198307A1
公开(公告)日：2010-06-23
申请号：EP08760196.9
申请日：2008-05-29
CPC分类号： G01N33/6887 , G01N2333/805 , G01N2800/324
摘要： The present invention relates to a method for diagnosing myocardial infarction in a subject who suffers from acute coronary syndrome and has a cardiac Troponin level, which is detectable, but lower than the level that is considered as being indicative for a myocardial infarction. Moreover, the present invention relates to a method for identifying a subject being susceptible to cardiac intervention, wherein the subject suffers from acute coronary syndrome and has a cardiac Troponin level which is detectable, but lower than a level that is considered as being indicative for a myocardial infarction. The methods of the present invention are based on the determination of myoglobin and, optionally, Heart-type fatty acid binding protein (H-FABP) in a sample of said subject and comparing the amount of myoglobin and, optionally, H-FABP to reference amounts. Also comprised by the present invention are kits or devices to carry out the methods of the present invention.
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公开(公告)号：EP2198307B1
公开(公告)日：2012-06-13
申请号：EP08760196.9
申请日：2008-05-29
CPC分类号： G01N33/6887 , G01N2333/805 , G01N2800/324
摘要： The present invention relates to a method for diagnosing myocardial infarction in a subject who suffers from acute coronary syndrome and has a cardiac Troponin level, which is detectable, but lower than the level that is considered as being indicative for a myocardial infarction. Moreover, the present invention relates to a method for identifying a subject being susceptible to cardiac intervention, wherein the subject suffers from acute coronary syndrome and has a cardiac Troponin level which is detectable, but lower than a level that is considered as being indicative for a myocardial infarction. The methods of the present invention are based on the determination of myoglobin and, optionally, Heart-type fatty acid binding protein (H-FABP) in a sample of said subject and comparing the amount of myoglobin and, optionally, H-FABP to reference amounts. Also comprised by the present invention are kits or devices to carry out the methods of the present invention.
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公开(公告)号：EP2167975A1
公开(公告)日：2010-03-31
申请号：EP08760194.4
申请日：2008-05-29
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/324
摘要： The present invention relates to a method for diagnosing myocardial infarction in a subject who suffers from acute coronary syndrome and has a cardiac Troponin level, which is detectable, but lower than the level that is considered as being indicative for a myocardial infarction. Moreover, the present invention relates to a method for identifying a subject being susceptible to cardiac intervention, wherein the subject suffers from acute coronary syndrome and has a cardiac Troponin level which is detectable, but lower than a level that is considered as being indicative for a myocardial infarction. The methods of the present invention are based on the determination of H-FABP and, optionally, myoglobin in a sample of said subject and comparing the amount of H-FABP and, optionally, myoglobin to reference amounts. Also comprised by the present invention are kits or devices to carry out the methods of the present invention.
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5.发明授权DETECTION OF ADVANCED GLYCATION ENDPRODUCTS IN A CEREBROSPINAL FLUID SAMPLE 有权方法脑脊液高级GLYZIERUNGSENDPRODUKTE的检测
公开(公告)号：EP1346227B1
公开(公告)日：2004-06-30
申请号：EP01985898.4
申请日：2001-12-18
CPC分类号： C12Q1/37 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The invitation relates to methods for measurement of at least one advanced glycation endproduct (AGE) in a cerebrospinal fluid (CSF) sample that has been pre-treated with a protease, detergene or chaotropic agent and to the use of these methods in the assessment of neurodegenerative disease.
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6.发明公开DETECTION OF ADVANCED GLYCATION ENDPRODUCTS IN A CEREBROSPINAL FLUID SAMPLE 有权方法脑脊液高级GLYZIERUNGSENDPRODUKTE的检测
公开(公告)号：EP1346227A1
公开(公告)日：2003-09-24
申请号：EP01985898.4
申请日：2001-12-18
CPC分类号： C12Q1/37 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The invitation relates to methods for measurement of at least one advanced glycation endproduct (AGE) in a cerebrospinal fluid (CSF) sample that has been pre-treated with a protease, detergene or chaotropic agent and to the use of these methods in the assessment of neurodegenerative disease.
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公开(公告)号：EP3359966A1
公开(公告)日：2018-08-15
申请号：EP16778831.4
申请日：2016-10-10
发明人： HORSCH, Andrea , KLAPPERICH, Birgit , BLOCK, Dirk , ENGEL, Alfred , KARL, Johann , KIENTSCH-ENGEL, Rosemarie , MANUILOVA, Ekaterina , RABE, Christina , RUTZ, Sandra , SOUKUPOVA, Monika , WIENHUES-THELEN, Ursula-Henrike , KASTNER, Peter , KAISER, Anna Edelgard
摘要： The present disclosure describes a method for predicting the risk of a patient to suffer from acute kidney injury (AKI) during or after a surgical procedure or after administration of a contrast medium. The method is based on the determination of the level of the biomarker IGFBP7 (Insulin-like Growth Factor Binding Protein 7) in a body fluid sample obtained from the patient prior to the surgical procedure or prior to the administration of a contrast medium. Further, the present disclosure describes a method for predicting the risk of a patient to suffer from acute kidney injury (AKI) based on the determination of the amount of the biomarker IGFBP7 (Insulin-like Growth Factor Binding Protein 7) and Cystatin C in a body fluid sample obtained from the patient. The present disclosure further encompasses kits and devices adapted to carry out the methods of the disclosed methods.
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公开(公告)号：EP3210026A1
公开(公告)日：2017-08-30
申请号：EP15781941.8
申请日：2015-10-20
发明人： DIETERLE, Thomas , NIESOR, Eric J. , KIENTSCH-ENGEL, Rosemarie , KLIMA, Horst , MODEL, Fabian , BUCKLAR, Gabriela , ROLNY, Vinzent
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/6815 , G01N33/74 , G01N2333/4737 , G01N2333/58 , G01N2800/32 , G01N2800/324 , G01N2800/50
摘要： Subject of the present invention are biomarkers and methods for the identification of risk for subsequent cardiovascular event (e.g. coronary heart disease death, non-fatal myocardial infarction, ischemic stroke, hospitalizations for unstable angina pectotis, cardiac arrest) in patients that have experienced an acute coronary syndrome, comprising the detecting the level of NT-proBNP, homocysteine and CRP.
摘要翻译： 本发明的主题是用于识别已经经历急性期的患者中的随后心血管事件（例如冠心病死亡，非致命性心肌梗塞，缺血性中风，不稳定型心绞痛住院治疗，心脏骤停）的风险的生物标志物和方法 包括检测NT-pro BNP，同型半胱氨酸和CRP的水平。
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9.发明公开L-FABP BASED DIAGNOSIS OF KIDNEY INJURY AFTER AN ACUTE EVENT OR AFTER A SURGICAL INTERVENTION 审中-公开后急性或手术后肾损伤的L-FABP-BASED诊断
公开(公告)号：EP2753936A1
公开(公告)日：2014-07-16
申请号：EP12753666.2
申请日：2012-09-01
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/53 , G01N2333/47 , G01N2800/347 , G01N2800/50
摘要： The present invention provides means and methods for diagnosing acute kidney injury associated after an acute event or after a surgical intervention based on the biomarker L-FABP. In addition, a method of predicting the risk of an individual to suffer from a kidney injury after an acute event or after a surgical intervention in the future is provided as well as corresponding uses and kits.
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10.发明授权MONOKLONALE ANTIKÖRPER GEGEN EINEN KOMPLEX AUS HUMANEM ACT UND EINER SERINPROTEASE 失效抗人ACT的复合物与一种丝氨酸蛋白酶单克隆抗体
公开(公告)号：EP0929579B1
公开(公告)日：2003-01-08
申请号：EP97911202.6
申请日：1997-10-09
发明人： HÜBNER-PARAJSZ, Christa , SCHETTERS, Hartmut , KIENTSCH-ENGEL, Rosemarie , MEIER, Thomas , KAUFMANN, Martin , GALLUSSER, Andreas , DEEG, Rolf
IPC分类号： C07K16/38 , C07K16/40 , C07K14/705 , C07K14/81 , C12N5/20 , C12N9/64 , G01N33/574
CPC分类号： C07K14/705 , C07K16/38 , C07K16/40 , G01N33/57434
摘要： The invention relates to monoclonal antibodies against a human ACT and serine protease complex, preferably ACT-PSA presenting no cross reactivity to free, non-complexed human ACT and free, non-complexed PSA, as well as diagnostic test methods to detect serine protease ACT complexes, using these monoclonal antibodies.
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