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    MASSIVELY PARALLEL DNA SEQUENCING APPARATUS
    2.
    发明公开
    MASSIVELY PARALLEL DNA SEQUENCING APPARATUS 审中-公开

    公开(公告)号：EP3408219A1

    公开(公告)日：2018-12-05

    申请号：EP17745013.7

    申请日：2017-01-27

    申请人： Roswell Biotechnologies, Inc

    发明人： CHOI, Chulmin ,  JIN, Sungho ,  MOLA, Paul, W. ,  MERRIMAN, Barry, L.

    IPC分类号： B82Y15/00 ,  C12Q1/68

    CPC分类号： G01N33/48721

    摘要： A DNA or genome sequencing structure is disclosed. The structure includes an electrode pair, each electrode having a tip-shaped end, the electrodes separated by a nanogap defined by facing tip-shaped ends; at least one conductive island deposited at or near each tip-shaped end; and a biomolecule having two ends, each end attached to the conductive islands in the electrode pair such that one biomolecule bridges over the nanogap in the electrode pair, wherein nucleotide interactions with the biomolecule provides electronic monitoring of DNA or genome sequencing without the use of a fluorescing element.

    BINDING PROBE CIRCUITS FOR MOLECULAR SENSORS
    3.
    发明公开
    BINDING PROBE CIRCUITS FOR MOLECULAR SENSORS 审中-公开

    公开(公告)号：EP4023764A2

    公开(公告)日：2022-07-06

    申请号：EP21203987.9

    申请日：2018-04-25

    申请人： Roswell Biotechnologies, Inc.

    发明人： MERRIMAN, Barry, L. ,  GOVINDARAJ, Venkatesh, Alagarswamy ,  MOLA, Paul ,  GEISER, Tim ,  COSTA, Gina

    IPC分类号： C12Q1/68 ,  G01N27/327 ,  G01N27/414 ,  G01N33/487

    摘要： In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and a binding probe molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the binding probe. In various examples, the binding probe is an antibody, the Fab domain of an antibody, a protein, a nucleic acid oligomer hybridization probe, or an aptamer. The circuit may further comprise molecular arms used to wire the binding probe to the electrodes. In various embodiments, the circuit functions as a sensor wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as targets interact with the binding probe. In various embodiments, the circuit provides a means to measure the presence, absence, or concentration of an analyte in a solution.

    BINDING PROBE CIRCUITS FOR MOLECULAR SENSORS
    6.
    发明公开
    BINDING PROBE CIRCUITS FOR MOLECULAR SENSORS 审中-公开

    公开(公告)号：EP4023764A3

    公开(公告)日：2022-09-21

    申请号：EP21203987.9

    申请日：2018-04-25

    申请人： Roswell Biotechnologies, Inc.

    发明人： MERRIMAN, Barry, L. ,  GOVINDARAJ, Venkatesh, Alagarswamy ,  MOLA, Paul ,  GEISER, Tim ,  COSTA, Gina

    IPC分类号： C12Q1/68 ,  G01N27/327 ,  G01N27/414 ,  G01N33/487

    摘要： In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and a binding probe molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the binding probe. In various examples, the binding probe is an antibody, the Fab domain of an antibody, a protein, a nucleic acid oligomer hybridization probe, or an aptamer. The circuit may further comprise molecular arms used to wire the binding probe to the electrodes. In various embodiments, the circuit functions as a sensor wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as targets interact with the binding probe. In various embodiments, the circuit provides a means to measure the presence, absence, or concentration of an analyte in a solution.