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    METHOD OF MAKING A SEQUENCING DEVICE
    1.
    发明公开
    METHOD OF MAKING A SEQUENCING DEVICE 审中-公开

    公开(公告)号：EP4137808A1

    公开(公告)日：2023-02-22

    申请号：EP22186552.0

    申请日：2017-01-27

    申请人： Roswell Biotechnologies, Inc.

    发明人： CHOI, Chulmin ,  JIN, Sungho ,  MOLA, Paul ,  MERRIMAN, Barry

    IPC分类号： G01N27/327

    摘要： The present invention provides a method of making a genome or DNA sequencing device, the method comprising the steps of:
    (a) disposing an array of electrode pairs (71) on a substrate, each electrode within a given pair of electrodes having a tip-shaped end, with the electrodes in each pair separated by a nanogap defined by tip-shaped ends facing one another;
    (b) electrodepositing gold at each tip-shaped end by applying a voltage to the electrode pair whereby high current density in the region of each tip-shaped end of each electrode directs preferential electrodeposition of gold to each tip-shaped end to form a gold nano-tip on each electrode; and
    (c) attaching each end of a biomolecule having two ends to the gold nano-tips such that one biomolecule bridges over each nanogap in each electrode pair.

    BINDING PROBE CIRCUITS FOR MOLECULAR SENSORS
    4.
    发明公开
    BINDING PROBE CIRCUITS FOR MOLECULAR SENSORS 审中-公开

    公开(公告)号：EP4023764A2

    公开(公告)日：2022-07-06

    申请号：EP21203987.9

    申请日：2018-04-25

    申请人： Roswell Biotechnologies, Inc.

    发明人： MERRIMAN, Barry, L. ,  GOVINDARAJ, Venkatesh, Alagarswamy ,  MOLA, Paul ,  GEISER, Tim ,  COSTA, Gina

    IPC分类号： C12Q1/68 ,  G01N27/327 ,  G01N27/414 ,  G01N33/487

    摘要： In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and a binding probe molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the binding probe. In various examples, the binding probe is an antibody, the Fab domain of an antibody, a protein, a nucleic acid oligomer hybridization probe, or an aptamer. The circuit may further comprise molecular arms used to wire the binding probe to the electrodes. In various embodiments, the circuit functions as a sensor wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as targets interact with the binding probe. In various embodiments, the circuit provides a means to measure the presence, absence, or concentration of an analyte in a solution.

    BINDING PROBE CIRCUITS FOR MOLECULAR SENSORS
    7.
    发明公开
    BINDING PROBE CIRCUITS FOR MOLECULAR SENSORS 审中-公开

    公开(公告)号：EP4023764A3

    公开(公告)日：2022-09-21

    申请号：EP21203987.9

    申请日：2018-04-25

    申请人： Roswell Biotechnologies, Inc.

    发明人： MERRIMAN, Barry, L. ,  GOVINDARAJ, Venkatesh, Alagarswamy ,  MOLA, Paul ,  GEISER, Tim ,  COSTA, Gina

    IPC分类号： C12Q1/68 ,  G01N27/327 ,  G01N27/414 ,  G01N33/487

    摘要： In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and a binding probe molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the binding probe. In various examples, the binding probe is an antibody, the Fab domain of an antibody, a protein, a nucleic acid oligomer hybridization probe, or an aptamer. The circuit may further comprise molecular arms used to wire the binding probe to the electrodes. In various embodiments, the circuit functions as a sensor wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as targets interact with the binding probe. In various embodiments, the circuit provides a means to measure the presence, absence, or concentration of an analyte in a solution.