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17 条记录 (耗时 0.016 秒)

    HYDROPHOBIC MODIFIED PEPTIDES AND THEIR USE FOR LIVER SPECIFIC TARGETING
    3.
    发明公开
    HYDROPHOBIC MODIFIED PEPTIDES AND THEIR USE FOR LIVER SPECIFIC TARGETING 有权
    HYDROPHOB MODIFIZIERTE PEPTIDE UND IHRE VERWENDUNGFÜRLEBERSPEZIFISCHES TARGETING

    公开(公告)号：EP2673004A1

    公开(公告)日：2013-12-18

    申请号：EP12704263.8

    申请日：2012-02-10

    申请人： Ruprecht-Karls-Universität Heidelberg

    发明人： MIER, Walter ,  URBAN, Stephan ,  MEHRLE, Stefan ,  HABERKORN, Uwe

    IPC分类号： A61K49/00 ,  A61K49/08 ,  A61K51/08 ,  C07K14/005 ,  A61K47/48

    CPC分类号： C07K7/08 ,  A61K47/542 ,  A61K47/64 ,  A61K51/0402 ,  A61K51/088 ,  C07K14/00

    摘要： The present invention relates to hydrophobic modified peptides for the specific delivery of compounds to the liver, preferably to hepatocytes, in vitro as well as in vivo. The present invention relates to pharmaceutical compositions comprising said hydrophobic modified peptide(s) and the compound(s) to be specifically delivered to the liver. The present invention furthermore relates to the use of the inventive hydrophobic modified peptides as well as to a method for the prevention and/or treatment of liver diseases or disorders.

    摘要翻译： 本发明涉及用于在体外和体内将化合物特异性递送至肝脏，优选肝细胞的疏水性修饰肽。 本发明涉及包含所述疏水性修饰肽和要特异性递送至肝脏的化合物的药物组合物。 本发明还涉及本发明的疏水性修饰肽的用途以及预防和/或治疗肝脏疾病或病症的方法。

    CONJUGATES OF PROTEINS AND MULTIVALENT CELL-PENETRATING PEPTIDES AND THEIR USES
    10.
    发明公开
    CONJUGATES OF PROTEINS AND MULTIVALENT CELL-PENETRATING PEPTIDES AND THEIR USES 审中-公开
    蛋白偶联物及其多VALENTE ZELLENPENETRIERENDE肽及其用途

    公开(公告)号：EP2928502A1

    公开(公告)日：2015-10-14

    申请号：EP13802328.8

    申请日：2013-12-04

    申请人： Ruprecht-Karls-Universität Heidelberg

    发明人： STRIEKER, Matthias ,  MIER, Walter ,  HABERKORN, Uwe

    IPC分类号： A61K47/48 ,  A61K49/00 ,  A61P9/00

    CPC分类号： C07K16/2863 ,  A61K47/56 ,  A61K47/641 ,  A61K47/645 ,  A61K51/088 ,  A61K51/103 ,  C07K2317/24

    摘要： The present invention relates to conjugates comprising a protein and multivalent cell-penetrating peptide(s), each multivalent cell-penetrating peptide comprising at least two cell-penetrating peptides, wherein the multivalent cell-penetrating peptide(s) is/are covalently attached to the protein. The present invention furthermore relates to a method of generating the conjugates and to their medical uses, in particular their use in the diagnosis, prevention and/or treatment of diseases. The present invention relates to methods of diagnosis, prevention and/or treatment of diseases, comprising administering the conjugates of the invention to a patient.

    摘要翻译： 本发明涉及缀合物，其包含蛋白质和多价细胞穿透肽（S），每个多价细胞穿透肽包括至少两个细胞穿透肽，worin多价细胞穿透肽（多个）/共价连接到 蛋白质。 本发明进一步更涉及一种产生缀合物的方法，以及它们的医药用途，特别是它们在诊断，预防和/或治疗的疾病中的用途。 本发明涉及诊断，预防和/或治疗的疾病的方法，包括给予本发明的缀合物的患者。