公开(公告)号：EP0407588A1

公开(公告)日：1991-01-16

申请号：EP89910209.9

申请日：1989-09-11

申请人： SAGAMI CHEMICAL RESEARCH CENTER

发明人： HIRAI, Kenji ,  NAKAMURA, Kazumi ,  FUJITA, Atsuko

IPC分类号： C07C59/84 ,  C07C59/86 ,  C07C59/90 ,  C07C51/347

CPC分类号： C07D333/24 ,  C07C51/347 ,  C07D317/60 ,  C07C63/14 ,  C07C59/84 ,  C07C59/86 ,  C07C59/90 ,  C07C59/88

摘要： The invention relates to a process for producing a 2-oxo-3-aromatic carboxylic acid derivative, which comprises reacting an aromatic pyruvic acid derivative with an electrophilic compound in a protic solvent in the presence of a base. This process can provide in good yields the 2-oxo-3-aromatic carboxylic acid derivatives which can be easily converted to aromatic amino acid derivatives or 2-aromatic alkanoic acid derivatives which are important intermediates for synthesizing medicines, agrochemicals, etc.

摘要翻译： 本发明涉及2-氧代-3-芳族羧酸衍生物的制备方法，该方法包括在碱存在下，在质子溶剂中使芳族丙酮酸衍生物与亲电子化合物反应。 该方法可以以良好的产率提供可以容易地转化为芳香族氨基酸衍生物的2-氧代-3-芳族羧酸衍生物或作为合成药物，农药等的重要中间体的2-芳香族链烷酸衍生物。

公开(公告)号：EP0407588B1

公开(公告)日：1993-12-08

申请号：EP89910209.9

申请日：1989-09-11

申请人： SAGAMI CHEMICAL RESEARCH CENTER

发明人： HIRAI, Kenji ,  NAKAMURA, Kazumi ,  FUJITA, Atsuko

IPC分类号： C07C59/84 ,  C07C59/86 ,  C07C59/90 ,  C07C51/347

CPC分类号： C07D333/24 ,  C07C51/347 ,  C07D317/60 ,  C07C63/14 ,  C07C59/84 ,  C07C59/86 ,  C07C59/90 ,  C07C59/88

摘要： The invention relates to a process for producing a 2-oxo-3-aromatic carboxylic acid derivative, which comprises reacting an aromatic pyruvic acid derivative with an electrophilic compound in a protic solvent in the presence of a base. This process can provide in good yields the 2-oxo-3-aromatic carboxylic acid derivatives which can be easily converted to aromatic amino acid derivatives or 2-aromatic alkanoic acid derivatives which are important intermediates for synthesizing medicines, agrochemicals, etc.

公开(公告)号：EP0386243A1

公开(公告)日：1990-09-12

申请号：EP88909613.7

申请日：1988-11-05

申请人： SAGAMI CHEMICAL RESEARCH CENTER ,  Chisso Corporation

发明人： HIRAI, Kenji ,  FUJITA, Atsuko ,  YOKOTA, Masahiro A-204 ,  YAMADA, Kaoru ,  ISHII, Yoshimitsu

IPC分类号： C07F15/00 ,  C07C87/14 ,  A61K31/28

CPC分类号： C07F15/0093

摘要： Novel platinum (II) complexes represented by general formula (I), wherein AB represents a bidentate diamine ligand, R 1 and R 2 independently represent a hydrogen atom or an alkyl group containing 1 to 8 carbon atoms, provided that R 1 and R 2 do not represent hydrogen atoms at the same time, Ar represents an aryl group, and n represents 0 or 1. The platinum (II) complexes have a strong growth inhibiting action on P-388 mouse leukemia cells and are used as novel substances having an oncostatic activity.

摘要翻译： 由通式（I）表示的新型铂（II）络合物，其中AB表示二齿二胺配体，R 1和R 2独立地表示氢原子或含有1至8个碳原子的烷基，条件是R 1和R 2不同时表示氢原子，Ar表示芳基，n表示0或1.铂（II）配合物对P-388小鼠白血病细胞具有强烈的生长抑制作用 并用作具有静电活性的新物质。