公开(公告)号：EP0082498B1

公开(公告)日：1989-11-02

申请号：EP82111732.2

申请日：1982-12-17

申请人： SAGAMI CHEMICAL RESEARCH CENTER

发明人： Tunemoto, Daiei ,  Kobori, Takeo ,  Kondo, Kiyosi ,  Murakami, Yasuo ,  Toshioka, Tadashi ,  Sakuma, Osamu ,  Kojima, Etsuko

IPC分类号： C07D501/20 ,  C07D499/50 ,  C07D277/38

CPC分类号： C07D277/20 ,  C07C57/58 ,  C07D277/42 ,  C07D499/00 ,  Y02P20/55

公开(公告)号：EP0082498A3

公开(公告)日：1985-01-23

申请号：EP82111732

申请日：1982-12-17

申请人： SAGAMI CHEMICAL RESEARCH CENTER

发明人： Tunemoto, Daiei ,  Kobori, Takeo ,  Kondo, Kiyosi ,  Murakami, Yasuo ,  Toshioka, Tadashi ,  Sakuma, Osamu ,  Kojima, Etsuko

IPC分类号： C07D501/20 ,  C07D499/50 ,  C07D277/38 ,  C07D277/46 ,  C07D277/42 ,  C07D277/40

CPC分类号： C07D277/20 ,  C07C57/58 ,  C07D277/42 ,  C07D499/00 ,  Y02P20/55

摘要： There are disclosed a compound having the following formula:
in which R 1 denotes a substituted or unsubstituted thiazolyl radical, a substituted or unsubstituted thiazolylmercapto radical or a substituted or unsubstituted phenyl radical; R 2 denotes a halogen atom, a cyano radical, a carbamoyl radical, a lower-alkylmercapto radical or an 0-lower-alkylcarboxyimidoyl radical; and Y represents a group
(wherein R 3 denotes hydrogen, a salt forming cation or a protective group for a carboxylic acid, and R denotes hydrogen or a residue of a nucleophilic compound); process for preparing the same; and an intermediate compound useful for preparing the same. The above mentioned compound has a broad antibacterial spectrum and shows strong antibacterial activities against not only gram-positive bacteria but also gram-negative bacteria, particularly the resistive gram-negative becteria.

公开(公告)号：EP0082498A2

公开(公告)日：1983-06-29

申请号：EP82111732.2

申请日：1982-12-17

申请人： SAGAMI CHEMICAL RESEARCH CENTER

发明人： Tunemoto, Daiei ,  Kobori, Takeo ,  Kondo, Kiyosi ,  Murakami, Yasuo ,  Toshioka, Tadashi ,  Sakuma, Osamu ,  Kojima, Etsuko

IPC分类号： C07D501/20 ,  C07D499/50 ,  C07D277/38

CPC分类号： C07D277/20 ,  C07C57/58 ,  C07D277/42 ,  C07D499/00 ,  Y02P20/55

摘要： There are disclosed a compound having the following formula:
in which R 1 denotes a substituted or unsubstituted thiazolyl radical, a substituted or unsubstituted thiazolylmercapto radical or a substituted or unsubstituted phenyl radical; R 2 denotes a halogen atom, a cyano radical, a carbamoyl radical, a lower-alkylmercapto radical or an 0-lower-alkylcarboxyimidoyl radical; and Y represents a group
(wherein R 3 denotes hydrogen, a salt forming cation or a protective group for a carboxylic acid, and R denotes hydrogen or a residue of a nucleophilic compound); process for preparing the same; and an intermediate compound useful for preparing the same.
The above mentioned compound has a broad antibacterial spectrum and shows strong antibacterial activities against not only gram-positive bacteria but also gram-negative bacteria, particularly the resistive gram-negative becteria.

摘要翻译： 公开了具有下式的化合物：其中R 1表示取代或未取代的噻唑基，取代或未取代的噻唑基巯基或取代或未取代的苯基的 R 2表示卤素原子，氰基，氨基甲酰基，低级烷基巯基或O-低级烷基羧基亚氨基; Y表示（其中R 3表示氢，成盐阳离子或羧酸保护基，R 4表示氢或亲核化合物的残基）。 制备方法; 和可用于制备该中间体的中间体化合物。 上述化合物具有广泛的抗菌谱，并且对革兰氏阳性细菌，革兰氏阴性细菌，特别是抗性革兰氏阴性菌也表现出强烈的抗菌活性。